515
Participants
Start Date
March 14, 2022
Primary Completion Date
January 29, 2026
Study Completion Date
January 29, 2027
Bemarituzumab
Bemarituzumab will be administered as intravenous (IV) infusion.
Nivolumab
Nivolumab will be administered as IV infusion.
Chemotherapy
"mFOLFOX6: 5-fluorouracil, leucovorin, and oxaliplatin will be administered as IV infusion.~OR CAPOX: oxaliplatin will be administered as IV infusion and capecitabine will be administered orally."
Placebo
Placebo will be administered as IV infusion.
Semmelweis Egyetem, Budapest
Universitaetsklinikum Allgemeines Krankenhaus Wien, Vienna
Universitair Ziekenhuis Brussel, Jette
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet, Budapest
Orszagos Onkologiai Intezet, Budapest
Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Brussels
Hopitaux Universitaires de Geneve, Geneva
Military Medical Academy Multiprofile Hospital for Active Treatment - Sofia, Sofia
Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia
Hospital Italiano de La Plata, La Plata
GenesisCare -North Shore Oncology, St Leonards
Calvary Mater Newcastle Hospital, Waratah
Algemeen Ziekenhuis Turnhout Campus Sint-Jozef, Turnhout
Universitair Ziekenhuis Antwerpen, Edegem
Krankenhaus Wiener Neustadt, Wiener Neustadt
Komarom-Esztergom Varmegyei Szent Borbala Korhaz, Tatabánya
Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven
Inselspital Bern, Bern
Austin Health, Austin Hospital, Heidelberg
Grampians Health, Ballarat
Centre Hospitalier Universitaire de Liege - Sart Tilman, Liège
Multiprofile Hospital for Active Treatment Central Onco Hospital OOD, Plovdiv
Universitaetsspital Basel, Basel
Debreceni Egyetem Klinikai Kozpont, Debrecen
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz, Nyíregyháza
Multiprofile Hospital for Active Treatment - Uni Hospital OOD, Panagyurishte
Fundacion Ars Medica, San Salvador de Jujuy
Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet, Szolnok
The Queen Elizabeth Hospital, Woodville South
Landeskrankenhaus Salzburg, Salzburg
Grand Hopital de Charleroi, Charleroi
Medizinische Universitaet Innsbruck, Innsbruck
Specialized Hospital for Active Treatment of Oncology - Haskovo EOOD, Haskovo
Hopital De Libramont, Libramont
Landeskrankenhaus Feldkirch, Rankweil
Kantonsspital Graubuenden, Chur
Tolna Varmegyei Balassa Janos Korhaz, Szekszárd
Complex Oncology Center - Burgas, Burgas
Medizinische Universitaet Graz, Graz
Onkozentrum Zuerich, Zurich
Universitaetsspital Zuerich, Zurich
Clinica Viedma, Viedma
Universitair Ziekenhuis Gent, Ghent
Memorial Sloan Kettering Cancer Center, New York
Chulabhorn Hospital, Bangkok
National Cancer Center, Goyang-si Gyeonggi-do
Siriraj Hospital, Bangkok
Taipei Veterans General Hospital, Taipei
Tri-Service General Hospital, Taipei
Charite - Universitaetsmedizin Berlin, Campus Virchow, Berlin
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do
Complexo Hospitalario Universitario A Coruna Hospital Teresa Herrera, A Coruña
Ospedale Policlinico San Martino IRCCS, Genova
Saint Lukes University Health Network, Allentown
IRCCS Ospedale San Raffaele, Milan
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan
Haematologisch Onkologische Praxis Eppendorf, Hamburg
Greater Baltimore Medical Center, Baltimore
Virginia Oncology Associates, Norfolk
Universitaetsklinikum Schleswig-Holstein, Kiel
Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii, Bergamo
Centre Hospitalier Regional Universitaire de Besancon, Hopital Jean Minjoz, Besançon
Istituto Ospedaliero Fondazione Poliambulanza, Brescia
Azienda Socio Sanitaria Territoriale di Cremona, Cremona
Hospital General Universitario Gregorio Maranon, Madrid
Hospital Universitario Ramon y Cajal, Madrid
Hospital Clinico San Carlos, Madrid
Hospital Universitario 12 de Octubre, Madrid
FirstHealth Cancer Center, Pinehurst
Medical University of South Carolina, Charleston
Centre Hospitalier Universitaire de Brest - Cavale Blanche, Brest
Medizinische Hochschule Hannover, Hanover
Hospital Universitario de Navarra, Pamplona
Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil, Toulouse
Mayo Clinic, Jacksonville
Adventist Health System/Sunbelt, Inc d/b/a AdventHealth Orlando, Orlando
Orlando Health Cancer Institute, Orlando
Institut Bergonie, Bordeaux
Hospital Universitario Central de Asturias, Oviedo
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan District
Florida Cancer Specialists - Fort Myers, Fort Myers
Chungnam National University Hospital, Daejeon
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes
Istituto Oncologico Veneto IRCCS, Padua
Sarah Cannon Research Institute, Nashville
West Cancer Center, Germantown
Klinikum der Stadt Wolfsburg, Wolfsburg
Hospital Universitario Marques de Valdecilla, Santander
China Medical University Hospital, Taichung
Hospital Universitario Virgen del Rocio, Seville
Kyungpook National University Chilgok Hospital, Daegu
Centre Hospitalier Universitaire Nord de Saint Etienne - Hopital Nord, Saint-Priest-en-Jarez
Gabrail Cancer Center, LLC, Canton
Centre Rene Gauducheau - Institut de Cancerologie de l Ouest, Saint-Herblain
Hospital Clinico Universitario de Valencia, Valencia
Hospital General Universitario de Valencia, Valencia
Henry Ford Health System, Detroit
Azienda Ospedaliero Universitaria Careggi, Florence
Maharaj Nakorn Chiang Mai Hospital, Chiang Mai
Aurora Health Care Metro Inc, Milwaukee
Jeonbuk National University Hospital, Jeonju-si, Jeollabuk-do
Johannes Gutenberg Universitaet Mainz, Mainz
Mayo Clinic, Rochester
Azienda Ospedaliera Universitaria Pisana, Pisa
Chiangrai Prachanukroh Hospital, Chiang Rai
Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez, Lille
Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona, Ancona
Krankenhaus Nordwest GmbH, Frankfurt am Main
University of Illinois Chicago, Chicago
Centre Hospitalier Universitaire de Clermont Ferrand, Hopital Estaing, Clermont-Ferrand
Institut de cancerologie Strasbourg Europe, Strasbourg
Universitaetsmedizin Mannheim, Mannheim
Centre Leon Berard, Lyon
Ente Ospedaliero IRCCS Saverio De Bellis, Castellana Grotte
National Cheng Kung University Hospital, Tainan City
Regional Kliniken Holding Klinikum Ludwigsburg, Ludwigsburg
Universitaetsklinikum der Eberhard Karls Universitaet Tuebingen, Tübingen
Hopital Europeen Georges Pompidou, Paris
Hopital Saint Louis, Paris
Institut Mutualiste Montsouris, Paris
Centre Hospitalier Universitaire de Rouen, Rouen
University of Texas MD Anderson Cancer Center, Houston
United States Oncology Regulatory Affairs Corporate Office, The Woodlands
US Oncology Research Investigational Products Center, The Woodlands
Texas Oncology Central-South, Austin
Centre Hospitalier Universitaire Amiens Picardie - Hopital Sud, Amiens
Azienda Ospedaliero Universitaria Luigi Vanvitelli, Napoli
Istituto Nazionale dei Tumori IRCCS Fondazione Giovanni Pascale, Napoli
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City
Klinikum der LMU Muenchen, München
Klinikum rechts der Isar der TUM, München
Mayo Clinic - Arizona, Phoenix
Centre Hospitalier Universitaire de Limoges - Hopital Dupuytren, Limoges
Universitaetsklinikum Ulm, Ulm
University of California Los Angeles, Los Angeles
Prince of Songkla Hospital, Songkhla
Cancer and Blood Specialty Clinic, Downey
Torrance Memorial Physician Network, Redondo Beach
Translational Research in Oncology - US Inc, Santa Monica
Translational Research in Oncology US Inc, Trio Central Pharmacy, Santa Monica
Presbyterian Intercommunity Hospital Health Whitter Hospital, Whittier
The Oncology Institute Clinical Research, Cerritos
City of Hope National Medical Center, Duarte
Olive View-University of California in Los Angeles Medical Center, Sylmar
University of California Irvine, Orange
Institut Gustave Roussy, Villejuif
Providence Cancer Institute Franz Clinic, Portland
Northwest Cancer Specialists - Vancouver, Vancouver
Cancer Hospital of Chinese Academy of Medical Sciences, Beijing
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing
Linfen Central Hospital, Linfen
Spitalul Municipal Ploiesti, Ploieşti
Liaoning Cancer Hospital, Shenyang
National University Hospital, Singapore
The First Bethune Hospital of Jilin University, Changchun
China-Japan Union Hospital of Jilin University, Changchun
Harbin Medical University Cancer Hospital, Harbin
National Cancer Centre Singapore, Singapore
Sociedad de Oncologia y Hematologia del Cesar, Valledupar
Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Zhongshan Hospital Fudan University, Shanghai
Shanghai East Hospital, Shanghai
Centrul de Oncologie Sf Nectarie SRL, Craiova
Nanjing Drum Tower Hospital, Nanjing
Zhongda Hospital Southeast University, Nanjing
The First People's Hospital of Changzhou, Changzhou
Affiliated Hospital of Jiangnan University, Wuxi
The Second Affiliated Hospital of Soochow University, Suzhou
The Affiliated Hospital of Xuzhou Medical University, Xuzhou
Affiliated Hospital of Yangzhou University, Yangzhou
Northern Jiangsu Peoples Hospital, Yangzhou
The First Affiliated Hospital of Anhui Medical University, Hefei
Anhui Provincial Cancer Hospital, Hefei
The First Affiliated Hospital of Bengbu Medical University, Bengbu
Qilu Hospital of Shandong University, Jinan
The Affiliated Cancer Hospital of Shandong First Medical University, Jinan
The Affiliated Hospital of Qingdao University, Qingdao
Affiliated Hospital of Jining Medical University, Jining
Tianjin Medical University Cancer institute and hospital, Tianjin
SC Oncomed SRL, Timișoara
The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou
The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
The First Affiliate Hospital of Ningbo University, Ningbo
Taizhou Hospital of Zhejiang Province, Linhai
Lishui Municipal central Hospital, Lishui
The First Affiliated Hospital of Nanchang University, Nanchang
Fujian Medical University Union Hospital, Fuzhou
Fujian Cancer Hospital, Fuzhou
The First Affiliated Hospital of Xiamen University, Xiamen
Institutul Regional de Gastroenterologie si Hepatologie Prof Dr Octavian Fodor, Cluj-Napoca
Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca, Cluj-Napoca
The First Affiliated Hospital of Chongqing Medical University, Chongqing
The Second Xiangya Hospital of Central South University, Changsha
Xiangya Hospital of Central South University, Changsha
Hunan Cancer Hospital, Changsha
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan
Tongji Hospital Tongji Medical College Of Hust, Wuhan
Hubei Cancer Hospital, Wuhan
Taihe Hospital Affiliated Hospital of Hubei University of Medicine, Shiyan
Henan Cancer Hospital, Zhengzhou
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
The First Affiliated Hospital of Henan University of science and Technology, Luoyang
Sun Yat-sen University Cancer Center, Guangzhou
Guangdong Provincial Peoples Hospital, Guangzhou
Cancer Hospital of Shantou University Medical College, Shantou
The first people's Hospital of Foshan, Foshan
Guangxi Medical University Cancer Hospital, Nanning
The First Affiliated Hospital of Hainan Medical University, Haikou
Sichuan Cancer Hospital, Chengdu
West China Hospital of Sichuan University, Chengdu
The Affiliated Hospital of Southwest Medical University, Luzhou
Yunnan Cancer Hospital, Kunming
Fundacion Oftalmologica de Santander - Foscal, Floridablanca
Fundacion Cardiovascular de Colombia, Bucaramanga
Institutul Regional de Oncologie Iasi, Iași
The First Affiliated Hospital of Xian Jiaotong University, Xi'an
Shaanxi Provincial People Hospital, Xi'an
Lanzhou University Second Hospital, Lanzhou
Gansu Provincial Cancer Hospital, Lanzhou
Gansu Wuwei Tumour Hospital, Wuwei
General Hospital of Ningxia Medical University, Yinchuan
IC La Serena Research, La Serena
Oncocentro Apys, Viña del Mar
Rambam Health Care Campus, Haifa
Sheba Medical Center, Ramat Gan
Tel-Aviv Sourasky Medical Center, Tel Aviv
Centro de Estudios Clinicos SAGA Spa, Santiago
Oncovida, Santiago
Centro De Estudios Clínicos Suecia SpA, Santiago
Icegclinic, Santiago
Centro de Estudios Clinicos e Investigaciones Medicas CeCim, Santiago
Shaare Zedek Medical Center, Jerusalem
Hadassah Ein-Kerem Medical Center, Jerusalem
Yale New Haven Hospital Yale Cancer Center, New Haven
Summit Medical Group, Florham Park
Stony Brook University Medical Center, Stony Brook
Cemic, Ciudad Autonoma de Buenos Aires
Centro Medico Austral, Buenos Aires
Hospital Provincial del Centenario, Rosario
Exelsus Oncologia Clinica, San Miguel de Tucumán
Fundacion Respirar, Buenos Aires
Hospital Italiano, Capital Federal
Sanatorio Allende, Córdoba
Hospital Privado Universitario de Cordoba, Córdoba
Centro Oncologico Riojano Integral, La Rioja
Institut Jules Bordet, Brussels
Hospital Haroldo Juacaba - Instituto do Cancer do Ceara, Fortaleza
Hospital Evangelico de Cachoeiro de Itapemirim, Cachoeiro de Itapemirim
Hospital Sirio Libanes, Brasília
Personal Oncologia de Precisao e Personalizada, Belo Horizonte
Liga Norte-Riograndense Contra O Cancer, Natal
Hospital das Clinicas de Porto Alegre, Porto Alegre
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital Mae de Deus, Porto Alegre
Fundacao Pio 12 Hospital de Amor de Barretos, Barretos
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, São José do Rio Preto
Instituto do Cancer Arnaldo Vieira de Carvalho, São Paulo
Sociedade Beneficente de Senhoras Hospital Sirio Libanes, São Paulo
Fundacao Antonio Prudente AC Camargo Cancer Center, São Paulo
Instituto Coi, Rio de Janeiro
Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp, São Paulo
London Health Sciences Centre, London
Princess Margaret Cancer Centre, Toronto
Sunnybrook Research Institute Sunnybrook Health Sciences Centre, Toronto
Centre Hospitalier de L Universite de Montreal, Montreal
Jewish General Hospital, Montreal
CHU de Quebec Hopital de l Enfant Jesus, Québec
Fourth Hospital of Hebei Medical University, Shijiazhuang
Inner Mongolia Autonomous Region Peoples Hospital, Hohhot
Changzhi Peoples Hospital, Changzhi
Hospital Pablo Tobon Uribe, Medellín
Institucion Prestadora de Servicios de Salud Sociedad Médica Rionegro SA Somer SA, Rionegro
Fakultni nemocnice Hradec Kralove, Hradec Králové
Fakultni nemocnice Olomouc, Olomouc
Fakultni nemocnice Kralovske Vinohrady, Prague
Vseobecna fakultni nemocnice v Praze, Prague
Fakultni Thomayerova nemocnice, Prague
Centre Antoine Lacassagne, Nice
Universitaetsklinikum Dresden, Dresden
Universitaetsklinikum Leipzig, Leipzig
Prince of Wales Hospital / CUHK, Shatin, New Territories
Nagoya University Hospital, Nagoya
Chiba Cancer Center, Chiba
National Cancer Center Hospital East, Kashiwa-shi
National Hospital Organization Shikoku Cancer Center, Matsuyama
National Hospital Organization Kyushu Cancer Center, Fukuoka
Gifu University Hospital, Gifu
Hokkaido University Hospital, Sapporo
Hyogo Cancer Center, Akashi-shi
Kobe City Medical Center General Hospital, Kobe
Yokohama City University Medical Center, Yokohama
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center, Yokohama
Niigata Cancer Center Hospital, Niigata
Kansai Medical University Hospital, Hirakata-shi
Osaka International Cancer Institute, Osaka
Kindai University Hospital, Osakasayama-shi
Osaka University Hospital, Suita-shi
Saitama Cancer Center, Kitaadachi-gun
Shizuoka Cancer Center, Sunto-gun
National Cancer Center Hospital, Chuo-ku
The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku
Beskidzkie Centrum Onkologii Szpital Miejski imienia Jana Pawla Drugiego, Bielsko-Biala
Narodowy Instytut Onkologii im M Sklodowskiej-Curie Panstwowy Instytut Badawczy Oddzial w Gliwicach, Gliwice
Przychodnia Lekarska Komed Roman Karaszewski, Konin
Samodzielny Publiczny Szpital Kliniczny Nr 1, Lublin
Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji, Olsztyn
Mazowiecki Szpital Wojewodzki im Sw Jana Pawla II w Siedlcach spzoo, Siedlce
Centrum Medyczne Pratia Poznan, Skorzewo
Uniwersytecki Szpital Kliniczny nr 1 im prof Tadeusza Sokolowskiego Pum w Szczecinie, Szczecin
Lux med onkologia sp zoo szpital szamocka, Warsaw
Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy, Warsaw
Mtz Clinical Research powered by Pratia, Warsaw
Uniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego we Wroclawiu, Wroclaw
Unidade Local de Saude de Braga, EPE, Braga
Unidade Local de Saude do Alto Ave, EPE, Guimarães
Hospital da Luz, SA, Lisbon
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria, Lisbon
Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano, Matosinhos Municipality
Hospital Cuf porto, Porto
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE, Porto
Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao, Porto
Institutul Clinic Fundeni, Bucharest
Korea University Anam Hospital, Seoul
Seoul National University Hospital, Seoul
Kangbuk Samsung Hospital, Seoul
Severance Hospital Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea Seoul St Marys Hospital, Seoul
Korea University Guro Hospital, Seoul
Hospital del Mar, Barcelona
Hospital Universitari Vall d Hebron, Barcelona
Hospital Clinic i Provincial de Barcelona, Barcelona
Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals, L'Hospitalet de Llobregat
Hospital General Universitario de Elche, Elche
Addenbrookes Hospital, Cambridge
University Hospital Coventry, Coventry
Ninewells Hospital and Medical School, Dundee
Royal Free Hospital, London
Guys Hospital, London
Christie Hospital, Manchester
Mount Vernon Cancer Centre, Northwood
Churchill Hospital, Oxford
Southampton General Hospital, Southampton
Torbay Hospital, Torquay
Lead Sponsor
Amgen
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