Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

PHASE2RecruitingINTERVENTIONAL
Enrollment

99

Participants

Timeline

Start Date

August 11, 2022

Primary Completion Date

December 19, 2025

Study Completion Date

December 19, 2025

Conditions
Anal MelanomaBladder MelanomaCervical MelanomaEsophageal MelanomaGallbladder MelanomaHead and Neck Mucosal MelanomaMucosal MelanomaNasopharyngeal Mucosal MelanomaOral Cavity Mucosal MelanomaPenile Mucosal MelanomaRectal MelanomaRecurrent Mucosal MelanomaSinonasal Mucosal MelanomaUrethral MelanomaUrinary System Mucosal MelanomaVaginal MelanomaVulvar Melanoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood and tissue sample collection

PROCEDURE

Bone Scan

Undergo bone scan

DRUG

Cabozantinib S-malate

Given PO

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Nivolumab

Given IV

DRUG

Placebo Administration

Given PO

PROCEDURE

Positron Emission Tomography

Undergo PET

Trial Locations (146)

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Westchester, Harrison

11042

RECRUITING

Northwell Health/Center for Advanced Medicine, Lake Success

11501

RECRUITING

NYU Langone Hospital - Long Island, Mineola

13031

RECRUITING

Hematology Oncology Associates of CNY at Camillus, Camillus

13057

RECRUITING

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

19090

ACTIVE_NOT_RECRUITING

Asplundh Cancer Pavilion, Willow Grove

19107

ACTIVE_NOT_RECRUITING

Thomas Jefferson University Hospital, Philadelphia

23235

RECRUITING

VCU Massey Cancer Center at Stony Point, Richmond

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

44106

RECRUITING

Case Western Reserve University, Cleveland

45220

RECRUITING

Good Samaritan Hospital - Cincinnati, Cincinnati

45331

RECRUITING

Miami Valley Cancer Care and Infusion, Greenville

45373

RECRUITING

Upper Valley Medical Center, Troy

45409

RECRUITING

Miami Valley Hospital, Dayton

RECRUITING

Premier Blood and Cancer Center, Dayton

45415

ACTIVE_NOT_RECRUITING

Dayton Physician LLC - Englewood, Dayton

RECRUITING

Miami Valley Hospital North, Dayton

45429

ACTIVE_NOT_RECRUITING

Kettering Medical Center, Kettering

45459

RECRUITING

Miami Valley Hospital South, Centerville

49007

RECRUITING

Bronson Methodist Hospital, Kalamazoo

RECRUITING

West Michigan Cancer Center, Kalamazoo

49009

RECRUITING

Beacon Kalamazoo Cancer Center, Kalamazoo

49017

RECRUITING

Bronson Battle Creek, Battle Creek

49085

RECRUITING

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

49120

RECRUITING

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

RECRUITING

Trinity Health Muskegon Hospital, Muskegon

RECRUITING

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

RECRUITING

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

RECRUITING

University of Michigan Health - West, Wyoming

49677

RECRUITING

Corewell Health Reed City Hospital, Reed City

49684

RECRUITING

Munson Medical Center, Traverse City

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50036

RECRUITING

McFarland Clinic - Boone, Boone

50129

RECRUITING

McFarland Clinic - Jefferson, Jefferson

50158

RECRUITING

McFarland Clinic - Marshalltown, Marshalltown

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50314

RECRUITING

Mercy Medical Center - Des Moines, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50501

RECRUITING

McFarland Clinic - Trinity Cancer Center, Fort Dodge

53081

RECRUITING

Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54154

RECRUITING

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54701

SUSPENDED

HSHS Sacred Heart Hospital, Eau Claire

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

55101

RECRUITING

Regions Hospital, Saint Paul

55102

RECRUITING

United Hospital, Saint Paul

55337

RECRUITING

Minnesota Oncology - Burnsville, Burnsville

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

RECRUITING

North Memorial Medical Health Center, Robbinsdale

55433

RECRUITING

Mercy Hospital, Coon Rapids

55435

RECRUITING

Fairview Southdale Hospital, Edina

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

57105

RECRUITING

Avera Cancer Institute, Sioux Falls

57701

ACTIVE_NOT_RECRUITING

Rapid City Regional Hospital, Rapid City

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59711

RECRUITING

Community Hospital of Anaconda, Anaconda

59715

RECRUITING

Bozeman Health Deaconess Hospital, Bozeman

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Logan Health Medical Center, Kalispell

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60462

RECRUITING

Northwestern Medicine Orland Park, Orland Park

60504

RECRUITING

Rush-Copley Medical Center, Aurora

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60560

RECRUITING

Rush-Copley Healthcare Center, Yorkville

60611

RECRUITING

Northwestern University, Chicago

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

73505

RECRUITING

Cancer Centers of Southwest Oklahoma Research, Lawton

77030

RECRUITING

M D Anderson Cancer Center, Houston

80113

ACTIVE_NOT_RECRUITING

The Melanoma and Skin Cancer Institute, Englewood

83605

SUSPENDED

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83687

SUSPENDED

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

SUSPENDED

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

90020

RECRUITING

Keck Medicine of USC Koreatown, Los Angeles

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

92663

RECRUITING

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

94086

SUSPENDED

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

RECRUITING

California Pacific Medical Center-Pacific Campus, San Francisco

94158

SUSPENDED

UCSF Medical Center-Mission Bay, San Francisco

94301

SUSPENDED

Palo Alto Medical Foundation Health Care, Palo Alto

94304

RECRUITING

Stanford Cancer Institute Palo Alto, Palo Alto

94401

RECRUITING

Mills Health Center, San Mateo

94538

RECRUITING

Palo Alto Medical Foundation-Fremont, Fremont

94589

RECRUITING

Sutter Solano Medical Center/Cancer Center, Vallejo

94704

RECRUITING

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95065

RECRUITING

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95355

SUSPENDED

Memorial Medical Center, Modesto

95403

RECRUITING

Sutter Pacific Medical Foundation, Santa Rosa

95602

RECRUITING

Sutter Auburn Faith Hospital, Auburn

95661

RECRUITING

Sutter Roseville Medical Center, Roseville

95816

RECRUITING

Sutter Medical Center Sacramento, Sacramento

97914

SUSPENDED

Saint Alphonsus Cancer Care Center-Ontario, Ontario

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge, Basking Ridge

45005-1066

RECRUITING

Atrium Medical Center-Middletown Regional Hospital, Franklin

54235-1495

RECRUITING

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

K1H 8L6

RECRUITING

Ottawa Hospital and Cancer Center-General Campus, Ottawa

M4N 3M5

RECRUITING

Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto

M5G 2M9

RECRUITING

University Health Network-Princess Margaret Hospital, Toronto

H3T 1E2

RECRUITING

Jewish General Hospital, Montreal

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH