Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

February 15, 2022

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
TumorTumor, SolidMetastasisMetastatic CancerCancerCancer MetastaticTumorsNeoplasmsNeoplasm MetastasisSolid TumorAdvanced Solid TumorAdvanced CancerMalignant Solid TumorMalignant Solid NeoplasmMalignant NeoplasmMalignant TumorTSCTSC1TSC2Metastatic Solid TumorMetastatic Neoplasm
Interventions
DRUG

nab-sirolimus

Prospective phase 2, open-label, multi-institutional basket trial to determine the efficacy and safety of nab-sirolimus administered by IV infusion to patients

Trial Locations (166)

10065

David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York

13057

HOACNY, East Syracuse

14263

Roswell Park Comprehensive Cancer Center, Buffalo

14850

Cayuga Medical Center, Ithaca

17325

Gettysburg-PCSRI, Gettysburg

17403

Cancer Care Associates of York - Parent, York

19047

Alliance Cancer Specialists, Langhorne

19107

Thomas Jefferson University, Philadelphia

20817

American Oncology Partners of Maryland PA (Center for Cancer & Blood Disorders), Bethesda

20850

Maryland Oncology Hematology, Rockville

21702

Frederick Health, Frederick

22031

Virginia Cancer Specialists, Fairfax

22408

Hematology Oncology Associates of Fredericksburg, Fredericksburg

23235

Virginia Urology, Richmond

27534

Southeastern Medical Oncology, Goldsboro

29605

Prisma Health Cancer Institute, Greenville

30303

Morehouse School of Medicine, Atlanta

32117

Cancer Specialist - East, Daytona Beach

32256

Cancer Specialists of North Florida, Jacksonville

32605

Florida Cancer Specialists - North Division, Gainesville

32701

Florida Cancer Specialists - North Division, Altamonte Springs

32763

Florida Cancer Specialists - North Division, Orange City

32778

Florida Cancer Specialists - North Division, Tavares

32806

Florida Cancer Specialists - North Division, Orlando

32960

Florida Cancer Specialists - East, Vero Beach

33308

Holy Cross Hospital, Fort Lauderdale

33401

Florida Cancer Specialists - East, West Palm Beach

33414

Florida Cancer Specialists - East, Wellington

33511

Florida Cancer Specialists - North Division, Brandon

33607

Florida Cancer Specialists - North Division, Tampa

33705

Florida Cancer Specialists and Research Institute - North Division, St. Petersburg

33707

Florida Cancer Specialists - North, St. Petersburg

33761

Florida Cancer Specialists - North Division, Clearwater

33770

Florida Cancer Specialists - North Division, Largo

33812

The Oncology Institute of Hope and Innovation, Lakeland

TOI Florida, Lakeland

33901

Florida Cancer Specialists South Division, Fort Myers

33905

Florida Cancer Specialists - South, Fort Myers

33908

Florida Cancer Specialists - South, Fort Myers

33909

Florida Cancer Specialists - South Division, Cape Coral

33980

Florida Cancer Specialists - South Division, Port Charlotte

34102

Florida Cancer Specialists - South Division, Naples

34135

Florida Cancer Specialists - South Division, Bonita Springs

34205

Florida Cancer Specialists - South Division, Bradenton

34211

Florida Cancer Specialists - South Division, Bradenton

34232

Florida Cancer Specialists - South Division, Sarasota

34236

Florida Cancer Specialists - South Division, Sarasota

34285

Florida Cancer Specialists - South Division, Venice

34292

Florida Cancer Specialists - South Division, Venice

34461

Florida Cancer Specialists - North Division, Lecanto

34474

Florida Cancer Specialists - North Division, Ocala

Ocala Oncology, Ocala

34655

Florida Cancer Specialists - North Division, Trinity

34994

Florida Cancer Specialist - East, Stuart

35243

Alabama Oncology, Birmingham

36607

Southern Cancer Center, Mobile

37055

Sarah Cannon and HCA Research Institute, Dickson

37066

Sarah Cannon and HCA Research Institute, Gallatin

37067

Sarah Cannon and HCA Research Institute, Franklin

37075

Sarah Cannon and HCA Research Institute, Henderson

37076

Sarah Cannon and HCA Research Institute, Hermitage

37090

Sarah Cannon and HCA Research Institute, Lebanon

37129

Sarah Cannon and HCA Research Institute, Murfreesboro

37160

Sarah Cannon and HCA Research Institute, Shelbyville

37167

Sarah Cannon and HCA Research Institute, Smyrna

37203

Sarah Cannon and HCA Research Institute, Nashville

37205

Sarah Cannon and HCA Research Institute, Nashville

37207

Sarah Cannon and HCA Research Institute, Nashville

37211

Sarah Cannon and HCA Research Institute, Nashville

38120

Baptist Cancer Center, Memphis

38138

West Cancer Center, Germantown

43623

The Toledo Clinic, Toledo

44195

Cleveland Clinic, Cleveland

44708

Aultman Medical Group, Canton

45220

TriHealth, Cincinnati

45627

University of Cincinnati (UC) - Cancer Institute, Cincinnati

46032

Urology of Indiana, Carmel

46526

Goshen Health, Goshen

46804

Fort Wayne Medical Oncology and Hematology, Fort Wayne

48108

Inje University Haeundae Paik Hospital, Busan

48201

Barbara Ann Karmanos Cancer Institute, Detroit

48912

Sparrow Hospital, Lansing

53705

University of Wisconsin - Carbone Cancer Center, Madison

54601

Gunderson Health System, La Crosse

54911

ThedaCare, Appleton

55404

Minnesota Oncology Hematology, Minneapolis

57105

Avera Cancer Institute, Sioux Falls

57117

Sanford Health, Sioux Falls

58102

Sanford Health-Fargo, Fargo

60008

Northwest Oncology and Hematology, Rolling Meadows

60521

Hope and Healing Cancer Services, Hinsdale

63110

Washington University School of Medicine, St Louis

64507

Mosaic Life Care, Saint Joseph

65065

Lake Regional, Osage Beach

65613

Central Care Cancer Center, Bolivar

65807

Oncology Hematology Associates, Springfield

68114

Nebraska Methodist Hospital, Omaha

68803

Nebraska Cancer Specialists, Grand Island

70403

Pontchartrain, Hammond

70817

Our Lady of the Lake, Baton Rouge

73104

Oklahoma State University (OSU) - Stephenson Cancer Center, Oklahoma City

74146

Oklahoma Cancer Specialist, Tulsa

75063

Arizona Oncology Associates, Irving

75230

Mary Crowley Cancer Research, Dallas

75246

Texas Oncology - DFW, Dallas

75702

Texas Oncology, Tyler

77030

MD Anderson Cancer Center, Houston

Oncology Consultants, Houston

77339

Lumi Research, Kingwood

78229

South Texas Accelerated Research Therapeutics (START), San Antonio

78503

Texas Oncology Central-South, McAllen

79915

Texas Oncology, El Paso

80012

Rocky Mountain Cancer Centers, Aurora

80120

Rocky Mountain Cancer Centers, Littleton

80124

Rocky Mountain Cancer Centers, Lone Tree

80218

Rocky Mountain Cancer Centers (Williams St), Denver

80220

Rocky Mountain Cancer Centers, Denver

80228

Rocky Mountain Cancer Centers, Lakewood

80260

Rocky Mountain Cancer Centers, Thornton

80303

Rocky Mountain Cancer Centers, Boulder

80501

Rocky Mountain Cancer Centers, Longmont

80907

Rocky Mountain Cancer Centers, Colorado Springs

81008

Rocky Mountain Cancer Centers, Pueblo

84106

Utah Cancer Specialists, Salt Lake City

84405

Community Cancer Trials of Utah, Ogden

85016

Honor Health, Phoenix

85364

Yuma Regional Medical Center, Yuma

85395

Arizona Oncology Associates, Goodyear

86301

Arizona Oncology Associates, Prescott Valley

89102

OptumCare Cancer Care-Parent, Las Vegas

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90033

USC Norris Comprehensive Cancer Center, Los Angeles

90095

UCLA - Jonsson Comprehensive Cancer Center, Los Angeles

90212

Nextgen Oncology, Beverly Hills

90403

Sarcoma Oncology Research Center, Santa Monica

90602

The Oncology Institute of Hope & Innovation, Whittier

90806

MemorialCare, Long Beach

91010

City of Hope, Duarte

92123

Sharp HealthCare, San Diego

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

92835

Providence Medical Foundation (Fullerton), Fullerton

93105

Ridley-Tree Cancer Center, Santa Barbara

93420

PCR Oncology, Arroyo Grande

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

94305

Stanford Cancer Center, Stanford

94558

Providence Medical Foundation (Napa), Napa

95403

Providence Medical Foundation, Santa Rosa

96813

Hawaii Cancer Center, Honolulu

98109

University of Washington Cancer Consortium, Seattle

98405

Northwest Medical Specialties, Tacoma

99202

Spokane Urology, Spokane

99216

Cancer Care Northwest, Spokane

06102

Hartford Healthcare, Hartford

06360

Eastern Connecticut Hematology and Oncology, Norwich

02215

Dana Farber Cancer Institute, Boston

02719

Southcoast Centers for Cancer Care, Fairhaven

07109

New Jersey Cancer Care and Blood Disorders, Belleville

07631

Englewood Hospital and Medical Center, Englewood

07932

Summit Medical Group - NJ, Florham Park

07960

Atlantic Health System - Morristown Medical Center, Morristown

00935

Pan Oncology Trials, LLC, San Juan

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

Sponsors
All Listed Sponsors
lead

Aadi Bioscience, Inc.

INDUSTRY

NCT05103358 - Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1) | Biotech Hunter | Biotech Hunter