First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

370

Participants

Timeline

Start Date

October 25, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Advanced Non-small Cell Lung CancerEGFR MutationHER2 Mutation
Interventions
DRUG

BAY2927088_formulation A

Oral administration

DRUG

BAY2927088_formulation B_1

Oral administration

DRUG

BAY2927088_formulation B_2

Oral administration

Trial Locations (81)

100

National Taiwan University Hospital, Taipei

704

National Cheng Kung University Hospital, Tainan City

3000

UZ Leuven Gasthuisberg - Pneumology Department, Leuven

3080

Seoul National University Hospital, Seoul

6351

Samsung Medical Center - Oncology Department, Seoul

8907

Institut Catala D'oncologia - Oncologia, Barcelona

10043

Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica, Orbassano

11501

NYU Langone Hospital - Long Island - Urology, Mineola

13620

Seoul National University Bundang Hospital, Seongnam-si

16247

St.Vincent's Hospital, Suwon

20089

Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia, Rozzano

20133

Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1, Milan

20141

Istituto Europeo di Oncologia s.r.l - Sviluppo di nuovi farmaci per Terapie Innovative, Milan

20817

The Center for Cancer and Blood Disorders, Bethesda

22031

Virginia Cancer Specialists, PC, Fairfax

28040

Hospital Universitario Fundacion Jimenez Diaz- Oncology Service, Madrid

28050

Centro Integral Oncológico Clara Campal, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

30322

Emory Winship Cancer Institute, Atlanta

33000

Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale, Bordeaux

33081

Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati, Aviano

33305

Chang Gung Memorial Hospital at Linkou, Taoyuan District

37134

Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia, Verona

37203

Tennessee Oncology - Nashville Centennial Clinic, Nashville

40705

Taichung Veterans General Hospital, Taichung

43126

Azienda Ospedaliero Universitaria Parma - SC Oncologia Medica, Parma

44093

Hopital Nord Laennec - Oncologie medicale thoracique et digestive, Nantes

44800

Institut de Cancerologie Ouest - Saint Herblain - Oncologie medicale, Saint-Herblain

46026

Hospital Universitario Y Politecnico La Fe - Oncologia, Valencia

48202

Brigette Harris Cancer Pavilion at Henry Ford Cancer Center - Detroit, Detroit

69373

UNICANCER - Centre Leon-Berard (CLB) - Medical oncology, Lyon

73657

Chi-Mei Medical Center, Liouyine, Tainan City

75248

Institut Curie - Paris - Oncologie medicale, Paris

77030

The University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston

85234

Banner MD Anderson Cancer Center at Banner Gateway Medical Center, Gilbert

91010

City of Hope - Duarte Cancer Center, Duarte

94805

Gustave Roussy - Departement Oncologie-Radiotherapie, Villejuif

100142

Beijing Cancer Hospital - Oncology Department, Beijing

100730

Beijing Hospital, Beijing

119074

National University Hospital Medical Centre, Singapore

150000

Harbin Medical University Cancer Hospital, Harbin

168583

National Cancer Center Singapore - Oncology Department, Singapore

200030

Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai

210008

NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School, Nanjing

250000

Qilu Hosp., Shandong Univ., Jinan

250117

Shandong University - Shandong Cancer Hospital, Jinan

310016

Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

317000

Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province, Taizhou

350014

Fujian Cancer Hospital, Fuzhou

410013

Hunan Cancer Hospital - Oncology Department, Changsha

430023

Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech, Wuhan

610041

West China Hospital Sichuan University, Chengdu

5262000

Chaim Sheba Medical Center, Ramat Gan

02215

Dana-Farber Cancer Institute - Oncology Department, Boston

West-Flanders

"AZ Delta , Clinical Trial Center - Pneumology"

Rio Grande do Norte

"Liga Norte Riograndense Contra o Cancer , Centro de Pesquisa Clínica"

São Paulo

"Hospital de Base , Integrated Research Center"

MISSING

Prince of Wales Hospital, Hong Kong

Queen Mary Hospital, Hong Kong

Unknown

"Rabin Medical Center , Beilinson Hospital - Internal Medicine C Department"

"Erasmus University Medical Center , Research Department - Lung Diseases"

"Curie Oncology , Mount Elizabeth Novena"

00128

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Fase I, Rome

464-8681

Aichi Cancer Center Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

060-8648

Hokkaido University Hospital, Sapporo

241-8515

Kanagawa Cancer Center, Yokohama

541-8567

Osaka International Cancer Institute, Osaka

589-8511

Kindai University Hospital, Sayama

411-8777

Shizuoka Cancer Center, Sunto

104-0045

National Cancer Center Hospital, Chuo-ku

683-8504

Tottori University Hospital, Yonago

700-8558

Okayama University Hospital, Okayama

1066 CX

Nederlands Kanker Instituut, Amsterdam

4200-072

IPO Porto, Porto

03722

Severance Hospital, Yonsei University Health System - Oncology Department, Seoul

05505

Asan Medical Center - Oncology Department, Seoul

08028

Hospital Quiron Dexeus - Oncologia, Barcelona

08035

Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY