A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

132

Participants

Timeline

Start Date

May 31, 2022

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
Malignant Glioma
Interventions
PROCEDURE

Biopsy Procedure

Undergo a biopsy

PROCEDURE

Magnetic Resonance Imaging

Undergo a MRI

RADIATION

Radiation Therapy

Undergo radiation therapy

DRUG

Selinexor

Given orally

Trial Locations (126)

1145

RECRUITING

Starship Children's Hospital, Grafton

2031

RECRUITING

Sydney Children's Hospital, Randwick

2145

RECRUITING

The Children's Hospital at Westmead, Westmead

3052

RECRUITING

Royal Children's Hospital, Parkville

4101

RECRUITING

Queensland Children's Hospital, South Brisbane

6009

RECRUITING

Perth Children's Hospital, Perth

8011

RECRUITING

Christchurch Hospital, Christchurch

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10467

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

11040

RECRUITING

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park

12208

RECRUITING

Albany Medical Center, Albany

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17822

RECRUITING

Geisinger Medical Center, Danville

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

19134

RECRUITING

Saint Christopher's Hospital for Children, Philadelphia

19803

RECRUITING

Alfred I duPont Hospital for Children, Wilmington

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23507

RECRUITING

Children's Hospital of The King's Daughters, Norfolk

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27834

RECRUITING

East Carolina University, Greenville

28204

RECRUITING

Novant Health Presbyterian Medical Center, Charlotte

29203

RECRUITING

Prisma Health Richland Hospital, Columbia

29605

RECRUITING

BI-LO Charities Children's Cancer Center, Greenville

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

32207

RECRUITING

Nemours Children's Clinic-Jacksonville, Jacksonville

32806

RECRUITING

Arnold Palmer Hospital for Children, Orlando

32827

RECRUITING

Nemours Children's Hospital, Orlando

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33176

ACTIVE_NOT_RECRUITING

Miami Cancer Institute, Miami

33607

RECRUITING

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa

33701

RECRUITING

Johns Hopkins All Children's Hospital, St. Petersburg

33908

RECRUITING

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

RECRUITING

Children's Hospital of Alabama, Birmingham

37203

RECRUITING

The Children's Hospital at TriStar Centennial, Nashville

37916

RECRUITING

East Tennessee Childrens Hospital, Knoxville

38105

RECRUITING

Saint Jude Children's Research Hospital, Memphis

39216

RECRUITING

University of Mississippi Medical Center, Jackson

40202

RECRUITING

Norton Children's Hospital, Louisville

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43205

RECRUITING

Nationwide Children's Hospital, Columbus

43606

RECRUITING

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

44106

RECRUITING

Rainbow Babies and Childrens Hospital, Cleveland

44308

RECRUITING

Children's Hospital Medical Center of Akron, Akron

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

RECRUITING

Dayton Children's Hospital, Dayton

46202

RECRUITING

Riley Hospital for Children, Indianapolis

48109

RECRUITING

C S Mott Children's Hospital, Ann Arbor

48201

RECRUITING

Children's Hospital of Michigan, Detroit

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

50309

RECRUITING

Blank Children's Hospital, Des Moines

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

RECRUITING

Children's Hospital of Wisconsin, Milwaukee

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

55404

RECRUITING

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55455

RECRUITING

University of Minnesota/Masonic Cancer Center, Minneapolis

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

61637

RECRUITING

Saint Jude Midwest Affiliate, Peoria

63104

RECRUITING

Cardinal Glennon Children's Medical Center, St Louis

63110

RECRUITING

Washington University School of Medicine, St Louis

63141

RECRUITING

Mercy Hospital Saint Louis, St Louis

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

68114

RECRUITING

Children's Hospital and Medical Center of Omaha, Omaha

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70118

RECRUITING

Children's Hospital New Orleans, New Orleans

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

75230

RECRUITING

Medical City Dallas Hospital, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

Cook Children's Medical Center, Fort Worth

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

RECRUITING

M D Anderson Cancer Center, Houston

78207

RECRUITING

Children's Hospital of San Antonio, San Antonio

78229

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

78723

RECRUITING

Dell Children's Medical Center of Central Texas, Austin

79905

RECRUITING

El Paso Children's Hospital, El Paso

80045

RECRUITING

Children's Hospital Colorado, Aurora

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

84113

RECRUITING

Primary Children's Hospital, Salt Lake City

85016

RECRUITING

Phoenix Childrens Hospital, Phoenix

85202

RECRUITING

Banner Children's at Desert, Mesa

90027

RECRUITING

Children's Hospital Los Angeles, Los Angeles

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

90806

RECRUITING

Miller Children's and Women's Hospital Long Beach, Long Beach

92123

RECRUITING

Rady Children's Hospital - San Diego, San Diego

92354

RECRUITING

Loma Linda University Medical Center, Loma Linda

92868

RECRUITING

Children's Hospital of Orange County, Orange

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

94304

RECRUITING

Lucile Packard Children's Hospital Stanford University, Palo Alto

94609

RECRUITING

UCSF Benioff Children's Hospital Oakland, Oakland

94611

RECRUITING

Kaiser Permanente-Oakland, Oakland

96826

RECRUITING

Kapiolani Medical Center for Women and Children, Honolulu

97227

RECRUITING

Legacy Emanuel Children's Hospital, Portland

97239

RECRUITING

Oregon Health and Science University, Portland

98105

RECRUITING

Seattle Children's Hospital, Seattle

98405

RECRUITING

Mary Bridge Children's Hospital and Health Center, Tacoma

99204

RECRUITING

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

72202-3591

RECRUITING

Arkansas Children's Hospital, Little Rock

06106

RECRUITING

Connecticut Children's Medical Center, Hartford

06520

RECRUITING

Yale University, New Haven

04401

RECRUITING

Eastern Maine Medical Center, Bangor

04074

RECRUITING

Maine Children's Cancer Program, Scarborough

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

07601

RECRUITING

Hackensack University Medical Center, Hackensack

07960

RECRUITING

Morristown Medical Center, Morristown

08903

SUSPENDED

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

07112

RECRUITING

Newark Beth Israel Medical Center, Newark

07503

RECRUITING

Saint Joseph's Regional Medical Center, Paterson

02903

RECRUITING

Rhode Island Hospital, Providence

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

T6G 2B7

RECRUITING

University of Alberta Hospital, Edmonton

V6H 3V4

SUSPENDED

British Columbia Children's Hospital, Vancouver

R3E 0V9

RECRUITING

CancerCare Manitoba, Winnipeg

B3K 6R8

RECRUITING

IWK Health Centre, Halifax

L8N 3Z5

RECRUITING

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

M5G 1X8

RECRUITING

Hospital for Sick Children, Toronto

H3H 1P3

RECRUITING

The Montreal Children's Hospital of the MUHC, Montreal

H3T 1C5

RECRUITING

Centre Hospitalier Universitaire Sainte-Justine, Montreal

J1H 5N4

RECRUITING

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke

S7N 0W8

RECRUITING

Jim Pattison Children's Hospital, Saskatoon

G1V 4G2

RECRUITING

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH