Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

82

Participants

Timeline

Start Date

March 15, 2022

Primary Completion Date

February 1, 2027

Study Completion Date

December 1, 2027

Conditions
Advanced Lung Non-Small Cell CarcinomaRecurrent Lung Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8Stage IIIC Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8Stage IVA Lung Cancer AJCC v8Stage IVB Lung Cancer AJCC v8
Interventions
DIETARY_SUPPLEMENT

Cobalamin

Given intramuscularly

DRUG

Dexamethasone

Given orally (PO)

DRUG

Docetaxel

Given IV

DIETARY_SUPPLEMENT

Folic Acid

Given PO

DRUG

Gemcitabine

Given IV

DRUG

Nogapendekin Alfa

Given SC

BIOLOGICAL

Pembrolizumab

Given IV

DRUG

Pemetrexed

Given IV

BIOLOGICAL

Ramucirumab

Given IV

Trial Locations (350)

11548

Cancer Institute at Saint Francis Hospital, East Hills

11795

Good Samaritan Hospital Medical Center, West Islip

13326

Mary Imogene Bassett Hospital, Cooperstown

14642

University of Rochester, Rochester

14905

Arnot Ogden Medical Center/Falck Cancer Center, Elmira

15009

UPMC-Heritage Valley Health System Beaver, Beaver

15065

UPMC Cancer Center-Natrona Heights, Natrona Heights

15108

UPMC-Coraopolis/Heritage Valley Radiation Oncology, Moon Township

15122

UPMC West Mifflin-Cancer Center Jefferson, West Mifflin

15132

UPMC Cancer Center at UPMC McKeesport, McKeesport

15146

UPMC Hillman Cancer Center - Monroeville, Monroeville

15219

UPMC-Mercy Hospital, Pittsburgh

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15243

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15301

UPMC Cancer Center-Washington, Washington

15401

UPMC Cancer Center-Uniontown, Uniontown

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

15642

Arnold Palmer Cancer Center Medical Oncology Norwin, N. Huntingdon

15666

UPMC Hillman Cancer Center - Part of Frick Hospital, Mount Pleasant

15701

IRMC Cancer Center, Indiana

15901

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown

16001

UPMC Hillman Cancer Center at Butler Health System, Butler

16066

UPMC Hillman Cancer Center - Passavant - Cranberry, Cranberry Township

16105

UPMC Hillman Cancer Center - New Castle, New Castle

16121

UPMC Cancer Center at UPMC Horizon, Farrell

16125

Oncology Hematology Associates, Greenville

16346

UPMC Cancer Center at UPMC Northwest, Seneca

16505

UPMC Hillman Cancer Center Erie, Erie

16601

UPMC Altoona, Altoona

17011

UPMC Camp Hill, Camp Hill

17015

Carlisle Regional Cancer Center, Carlisle

17042

Sechler Family Cancer Center, Lebanon

17050

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

17109

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17201

WellSpan Medical Oncology and Hematology, Chambersburg

17325

Adams Cancer Center, Gettysburg

17403

Cancer Care Associates of York, York

WellSpan Health-York Cancer Center, York

WellSpan Health-York Hospital, York

17408

UPMC Memorial, York

17522

Ephrata Cancer Center, Ephrata

17754

Divine Providence Hospital, Williamsport

19111

Fox Chase Cancer Center, Philadelphia

19140

Temple University Hospital, Philadelphia

19464

Pottstown Hospital, Pottstown

19713

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19901

Bayhealth Hospital Kent Campus, Dover

19945

Beebe South Coastal Health Campus, Frankford

19963

Bayhealth Hospital Sussex Campus, Milford

19971

Beebe Health Campus, Rehoboth Beach

20002

Kaiser Permanente-Capitol Hill Medical Center, Washington D.C.

20774

Kaiser Permanente - Largo Medical Center, Largo

20879

Kaiser Permanente-Gaithersburg Medical Center, Gaithersburg

20895

Kaiser Permanente - Kensington Medical Center, Kensington

21157

William E Kahlert Regional Cancer Center/Sinai Hospital, Westminster

21244

Kaiser Permanente-Woodlawn Medical Center, Baltimore

21502

UPMC Western Maryland, Cumberland

22015

Kaiser Permanente-Burke Medical Center, Burke

22102

Kaiser Permanente Tysons Corner Medical Center, McLean

25304

West Virginia University Charleston Division, Charleston

25701

Edwards Comprehensive Cancer Center, Huntington

26506

West Virginia University Healthcare, Morgantown

27203

Randolph Hospital, Asheboro

27215

Cone Health Cancer Center at Alamance Regional, Burlington

27302

Cone Heath Cancer Center at Mebane, Mebane

27320

Annie Penn Memorial Hospital, Reidsville

27403

Cone Health Cancer Center, Greensboro

27607

Duke Women's Cancer Care Raleigh, Raleigh

27609

Duke Raleigh Hospital, Raleigh

27705

Durham VA Medical Center, Durham

27710

Duke University Medical Center, Durham

28374

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

28721

AdventHealth Infusion Center Haywood, Clyde

28787

AdventHealth Infusion Center Weaverville, Weaverville

28792

AdventHealth Hendersonville, Hendersonville

28803

AdventHealth Infusion Center Asheville, Asheville

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29401

Ralph H Johnson VA Medical Center, Charleston

29425

Medical University of South Carolina, Charleston

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29621

AnMed Health Cancer Center, Anderson

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30046

Northside Hospital - Gwinnett, Lawrenceville

30096

Northside Hospital - Duluth, Duluth

30342

Northside Hospital, Atlanta

30501

Northeast Georgia Medical Center-Gainesville, Gainesville

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

33140

Mount Sinai Medical Center, Miami Beach

35233

Veterans Administration Medical Center - Birmingham, Birmingham

39216

University of Mississippi Medical Center, Jackson

40536

University of Kentucky/Markey Cancer Center, Lexington

42303

Owensboro Health Mitchell Memorial Cancer Center, Owensboro

43015

Delaware Health Center-Grady Cancer Center, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

43081

Saint Ann's Hospital, Westerville

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

43215

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43228

Doctors Hospital, Columbus

43302

OhioHealth Marion General Hospital, Marion

43560

ProMedica Flower Hospital, Sylvania

43701

Genesis Healthcare System Cancer Care Center, Zanesville

43952

Trinity's Tony Teramana Cancer Center, Steubenville

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

South Pointe Hospital, Warrensville Heights

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44195

Cleveland Clinic Foundation, Cleveland

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

44708

Cleveland Clinic Mercy Hospital, Canton

44870

North Coast Cancer Care, Sandusky

44906

Cleveland Clinic Cancer Center Mansfield, Mansfield

45504

Springfield Regional Cancer Center, Springfield

45505

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45714

Strecker Cancer Center-Belpre, Belpre

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

46601

Memorial Hospital of South Bend, South Bend

48044

Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb

48054

Great Lakes Cancer Management Specialists-Doctors Park, East China Township

48075

Ascension Providence Hospitals - Southfield, Southfield

48093

Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren

Saint John Macomb-Oakland Hospital, Warren

48106

Saint Joseph Mercy Hospital, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

Saint Joseph Mercy Brighton, Brighton

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48118

Saint Joseph Mercy Chelsea, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

Saint Joseph Mercy Canton, Canton

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48236

Ascension Saint John Hospital, Detroit

Academic Hematology Oncology Specialists, Grosse Pointe Woods

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods

48312

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights

48374

Ascension Providence Hospitals - Novi, Novi

48503

Genesee Cancer and Blood Disease Treatment Center, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48764

Ascension Saint Joseph Hospital, Tawas City

48912

Sparrow Hospital, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49009

Ascension Borgess Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49085

Marie Yeager Cancer Center, Saint Joseph

50010

Mary Greeley Medical Center, Ames

McFarland Clinic PC - Ames, Ames

50036

McFarland Clinic PC-Boone, Boone

50129

McFarland Clinic PC-Jefferson, Jefferson

50158

McFarland Clinic PC-Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50314

Mission Cancer and Blood - Laurel, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

Mercy Cancer Center-West Lakes, Clive

50501

McFarland Clinic PC-Trinity Cancer Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

52403

Mercy Hospital, Cedar Rapids

Oncology Associates at Mercy Medical Center, Cedar Rapids

52722

University of Iowa Healthcare Cancer Services Quad Cities, Bettendorf

53024

Aurora Cancer Care-Grafton, Grafton

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53066

Aurora Medical Center in Summit, Summit

53095

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53548

Mercyhealth Hospital and Cancer Center - Janesville, Janesville

53792

University of Wisconsin Carbone Cancer Center, Madison

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54601

Gundersen Lutheran Medical Center, La Crosse

54806

Duluth Clinic Ashland, Ashland

55072

Essentia Health Sandstone, Sandstone

55101

Regions Hospital, Saint Paul

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55417

Minneapolis VA Medical Center, Minneapolis

55432

Unity Hospital, Fridley

55746

Essentia Health Hibbing Clinic, Hibbing

55792

Essentia Health Virginia Clinic, Virginia

55805

Essentia Health Cancer Center, Duluth

56601

Sanford Joe Lueken Cancer Center, Bemidji

56636

Essentia Health - Deer River Clinic, Deer River

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59715

Bozeman Deaconess Hospital, Bozeman

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60141

Edward Hines Jr VA Hospital, Hines

60611

Northwestern University, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61103

Mercyhealth Javon Bea Hospital - Rockton, Rockford

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle on Vermilion, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

63080

Missouri Baptist Sullivan Hospital, Sullivan

63110

Washington University School of Medicine, St Louis

63127

Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

Truman Medical Centers, Kansas City

64116

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

66044

Lawrence Memorial Hospital, Lawrence

66061

Olathe Health Cancer Center, Olathe

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

66606

University of Kansas Health System Saint Francis Campus, Topeka

67208

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

67401

Salina Regional Health Center, Salina

67601

HaysMed University of Kansas Health System, Hays

70809

Louisiana Hematology Oncology Associates LLC, Baton Rouge

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

79106

The Don and Sybil Harrington Cancer Center, Amarillo

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

85338

CTCA at Western Regional Medical Center, Goodyear

87102

University of New Mexico Cancer Center, Albuquerque

87110

Presbyterian Kaseman Hospital, Albuquerque

87124

Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho

88011

Memorial Medical Center - Las Cruces, Las Cruces

89102

OptumCare Cancer Care at Charleston, Las Vegas

89148

OptumCare Cancer Care at Fort Apache, Las Vegas

89502

Renown Regional Medical Center, Reno

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90034

Kaiser Permanente West Los Angeles, Los Angeles

90048

Cedars Sinai Medical Center, Los Angeles

90211

Tower Cancer Research Foundation, Beverly Hills

90505

Torrance Memorial Physician Network - Cancer Care, Torrance

90602

Presbyterian Intercommunity Hospital, Whittier

90706

Kaiser Permanente-Bellflower, Bellflower

90710

Kaiser Permanente - Harbor City, Harbor City

91367

Kaiser Permanente-Woodland Hills, Woodland Hills

91402

Kaiser Permanente - Panorama City, Panorama City

91706

Kaiser Permanente-Baldwin Park, Baldwin Park

91761

Kaiser Permanente-Ontario, Ontario

92078

Kaiser Permanente-San Marcos, San Marcos

92120

Kaiser Permanente-San Diego Zion, San Diego

92270

Eisenhower Medical Center, Rancho Mirage

92335

Kaiser Permanente-Fontana, Fontana

92505

Kaiser Permanente-Riverside, Riverside

92618

Kaiser Permanente-Irvine, Irvine

92806

Kaiser Permanente-Anaheim, Anaheim

93420

PCR Oncology, Arroyo Grande

94080

Kaiser Permanente-South San Francisco, South San Francisco

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

California Pacific Medical Center-Pacific Campus, San Francisco

Kaiser Permanente-San Francisco, San Francisco

94121

Veterans Affairs Medical Center - San Francisco, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94538

Palo Alto Medical Foundation-Fremont, Fremont

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

Sutter Solano Medical Center/Cancer Center, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95065

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95355

Memorial Medical Center, Modesto

95602

Sutter Auburn Faith Hospital, Auburn

95661

Kaiser Permanente-Roseville, Roseville

Sutter Roseville Medical Center, Roseville

95814

Kaiser Permanente Downtown Commons, Sacramento

95816

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

97227

Kaiser Permanente Northwest, Portland

97239

Oregon Health and Science University, Portland

06516

Veterans Affairs Connecticut Healthcare System-West Haven Campus, West Haven

04330

Harold Alfond Center for Cancer Care, Augusta

04005

MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford, Biddeford

04412

Lafayette Family Cancer Center-EMMC, Brewer

04073

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford, Sanford

01915

Beverly Hospital, Beverly

01805

Lahey Hospital and Medical Center, Burlington

01930

Addison Gilbert Hospital, Gloucester

01960

Lahey Medical Center-Peabody, Peabody

01655

UMass Memorial Medical Center - University Campus, Worcester

03301

New Hampshire Oncology Hematology PA-Concord, Concord

03756

Dartmouth Hitchcock Medical Center, Lebanon

03103

Solinsky Center for Cancer Care, Manchester

08057

Virtua Samson Cancer Center, Moorestown

08043

Virtua Voorhees, Voorhees Township

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54235-1495

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

SWOG Cancer Research Network

NETWORK