Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

PHASE1RecruitingINTERVENTIONAL
Enrollment

260

Participants

Timeline

Start Date

June 30, 2021

Primary Completion Date

May 20, 2025

Study Completion Date

May 20, 2025

Conditions
OSASleep ApneaObstructive Sleep ApneaAlzheimer Disease
Interventions
OTHER

Supplemental Oxygen

Subjects will be instrumented with a nasal cannula to receive 2L/min supplemental oxygen. The oxygen will be kept at a fixed rate, however, the participant will be titrated to receive a max of 4 liters per min to maintain sats \>90% based on oximetry readings.

DEVICE

Continuous Positive Airway Pressure Machine

Continuous positive airway pressure is a form of positive airway pressure ventilation in which a constant level of pressure greater than atmospheric pressure is continuously applied to the upper respiratory tract of a person.

OTHER

Room Air

Subjects will be instrumented with a nasal cannula to receive 2L/min pressurized room air. The room air will be kept at a fixed rate, however, the participant will be titrated to receive a max of 4 liters per min to maintain sats \>90% based on oximetry readings.

Trial Locations (1)

92037

RECRUITING

UCSD Sleep Research, La Jolla

All Listed Sponsors
lead

University of California, San Diego

OTHER

NCT05094271 - Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease? | Biotech Hunter | Biotech Hunter