A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)

PHASE3CompletedINTERVENTIONAL
Enrollment

6,105

Participants

Timeline

Start Date

November 2, 2021

Primary Completion Date

November 20, 2024

Study Completion Date

February 5, 2025

Conditions
Chronic Heart Failure With Reduced Ejection Fraction
Interventions
DRUG

Vericiguat

2.5, 5.0, or 10.0 mg orally once daily

DRUG

Placebo

0 mg matching placebo for 2.5 mg, 5 mg, and 10 mg of vericiguat

Trial Locations (519)

300

Mackay Memorial Hospital-Hsinchu ( Site 3852), Hsinchu

333

Chang Gung Medical Foundation-Linkou Branch ( Site 3854), Taoyuan District

407

Taichung Veterans General Hospital ( Site 3855), Taichung

807

Kaohsiung Medical University Hospital ( Site 3856), Kaohsiung City

1023

Auckland City Hospital ( Site 2659), Auckland

1085

Szent Rókus Kórház ( Site 1858), Budapest

1096

Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1851), Budapest

1122

Semmelweis University-Városmajori Szív- és Érgyógyászati Klinika ( Site 1855), Budapest

1210

Klinik Floridsdorf-Karl Landsteiner Institute for Cardiovascular and Critical Care Research c/o Dep, Vienna

1685

Midrand Medical Centre ( Site 3466), Midrand

1821

Lenasia Clinical Trial Centre - Johannesburg ( Site 3470), Johannesburg

1932

Óbudai Egészségügyi Centrum ( Site 1861), Budapest

2013

Chris Hani Baragwanath Academic Hospital ( Site 3455), Soweto

2025

Middlemore Clinical Trials ( Site 2658), Auckland

2100

Rigshospitalet-Cardiology ( Site 1161), Copenhagen

2143

Flor Ferenc Hospital of Pest County-5th Department of Internal Medicine ( Site 1852), Kistarcsa

2196

Netcare Sunninghill Hospital ( Site 3457), Johannesburg

2300

Amager Hospital ( Site 1163), Copenhagen

2650

Hvidovre Hospital-259 ( Site 1151), Hvidovre

2900

Herlev and Gentofte Hospital-Department of Cardiology ( Site 1158), Hellerup

3000

Centro de Investigaciones Clinicas del Litoral ( Site 4354), Santa Fe

3204

Waikato Hospital-Cardiology Clinical Trials Unit ( Site 2654), Hamilton

3400

Nordsjællands Hospital - Hillerød ( Site 1159), Hillerød

4000

Roskilde Sygehus ( Site 1162), Roskilde

4001

Enhancing Care Foundation ( Site 3456), Durban

4029

Royal Brisbane and Women's Hospital-Cardiology Research ( Site 0453), Brisbane

4032

The Prince Charles Hospital-Cardiology Research Centre ( Site 0451), Brisbane

4064

Core Research Group ( Site 0452), Brisbane

4200

Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1153), Slagelse

4300

Holbæk Sygehus-Cardiology ( Site 1152), Holbæk

4400

Medifarma 98 Kft-Outpatient Clinic ( Site 1859), Nyíregyháza

5000

Royal Adelaide Hospital-Cardiology ( Site 0456), Adelaide

5010

Hutt Valley District Health board HVDHB-Cardiology Research Unit ( Site 2652), Lower Hutt

5020

Uniklinikum Salzburg-Universitätsklinik für Innere Medizin II, Kardiologie, Internistische Intensiv, Salzburg

5042

Flinders Medical Centre-Cardiology Research ( Site 0455), Bedford Park

5280

Krankenhaus St. Josef Braunau ( Site 0354), Braunau am Inn

5600

Private Practice - Dr. Lakatos Ferenc ( Site 1854), Békéscsaba

5700

Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1156), Svendborg

Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Cardiology ( Site 1878), Gyula

6000

Bacs-Kiskun Megyei Korhaz-I. Belgyógyászat - Kardiológia ( Site 1873), Kecskemét

6008

St. John of God Subiaco Hospital ( Site 0457), Subiaco

6529

Excellentis Clinical Trial Consultants ( Site 3464), George

6700

Sydvestjysk Sygehus Esbjerg-Hjertemedicinsk Projekt ( Site 1154), Esbjerg

6725

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1874), Szeged

7100

Tolna Megyei Balassa János Kórház ( Site 1868), Szekszárd

7500

TREAD Research ( Site 3451), Cape Town

7530

Tiervlei Trial Centre ( Site 3461), Bellville, Cape Town

7623

CoroMed ( Site 1867), Pécs

7624

Pécsi Tudományegyetem Klinikai Központ ( Site 1865), Pécs

7646

Paarl Research Centre ( Site 3468), Paarl

7925

Professor Ntsekhe Cardiology Clinic ( Site 3454), Cape Town

8000

CMed Rehabilitacios es Diagnosztikai Kozpont ( Site 1877), Székesfehérvár

8011

Christchurch Heart Institute ( Site 2651), Christchurch

8036

Medizinische Universität Graz-Department of Cardiology ( Site 0351), Graz

8200

Aarhus Universitetshospital, Skejby ( Site 1160), Aarhus

8230

DRC Gyógyszervizsgáló Központ ( Site 1869), Balatonfüred

8800

Regionshospitalet Viborg ( Site 1166), Viborg

8900

OEC Clinical Research - Zalaegerszeg ( Site 1864), Zalaegerszeg

9016

Dunedin Hospital-Cardiology Department ( Site 2653), Dunedin

9200

TaNa Med ( Site 1866), Mosonmagyaróvár

9321

Universitas Private Hospital-Cardiology Research ( Site 3453), Bloemfontein

9800

Sygehus Vendsyssel Hjoerring ( Site 1164), Hjørring

10002

"Communal Enterprise Hospital #1 of Zhytomyr City Council-Advisory and Treatment department of Sci", Zhytomyr

10126

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 2165), Torino

10400

Centro de Imagen y Tecnología en Intervención Cardiovascular ( Site 2477), Mexico City

10455

CHEAR Center LLC ( Site 0009), The Bronx

10567

New York Presbyterian Medical Group Hudson Valley Cardiology ( Site 0127), Cortlandt Manor

10789

Praxis Rankestrasse ( Site 1461), Berlin

11217

Taipei Veterans General Hospital-General Clinical Research Center ( Site 3851), Taipei

11527

"General Hospital of Athens G. Gennimatas-General Hospital of Athens G.Gennimatas ( Site 1561)", Athens

12808

Vseobecna fakultni nemocnice v Praze-Centrum srdečního selhání ( Site 1059), Prague

13001

Centro de investigacion Clínica Trujillo-Medical specialties ( Site 2860), Trujillo

14021

Institut Klinicke a Experimentalni Mediciny-Klinika kardiologie ( Site 1052), Prague

14068

Hallym University Sacred Heart Hospital-Cardiovascular center ( Site 3556), Anyang-si

14080

Instituto Nacional de Cardiologia Ignacio Chavez ( Site 2454), Mexico City

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 2474), Mexico City

14215

Erie County Medical Center ( Site 0160), Buffalo

15006

CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 3666), A Coruña

15036

Clínica Vesalio-Cardiology ( Site 2854), Lima

15046

Clínica Javier Prado ( Site 2853), Lima

15072

Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2855), Jesús María

15076

Clínica El Golf-Cardiologia ( Site 2857), Lima

15088

Clínica Providencia ( Site 2856), Lima

15706

CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 3651), Santiago de Compostela

16150

Hospital Universiti Sains Malaysia-Medical Department ( Site 2357), Kubang Kerian

17475

Universitätsmedizin Greifswald ( Site 1470), Greifswald

18000

"Communal non-profit enterprise Cherkasy Regional Hospital of Сherkasy Regional Council ( Site 4292", Cherkasy

18009

Cherkasy Regional Hospital-Cardiorheumatology ( Site 4283), Cherkasy

18901

Doylestown Hospital-Cardiology ( Site 0030), Doylestown

20000

Clínica Belén ( Site 2858), Piura

20109

Carient Heart & Vascular - Manassas ( Site 0059), Manassas

20122

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-U.O.C. Cardiologia ( Site 2161), Milan

20138

Centro Cardiologico Monzino-Heart Failure Unit ( Site 2153), Milan

20162

ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 2159), Milan

20230

Fundación Cardiovascular de Aguascalientes A.C. ( Site 2473), Aguascalientes

20400

Hospital Sultanah Nur Zahirah-Jabatan Perubatan ( Site 2360), Kuala Terengganu

20706

Capitol Cardiology Associates - Lanham Office-Maryland Research Centers ( Site 0167), Lanham

21029

Ukrayins'kyy Derzhavnyy Naukovo-Doslidnyy Instytut Rebilitatsiyi Invalidiv ( Site 4274), Vinnytsia

21229

Maryland Cardiovascular Specialists ( Site 0056), Baltimore

21565

Gachon University Gil Medical Center ( Site 3559), Namdong-gu

22041

Cardiologicum Hamburg ( Site 1467), Hamburg

22042

INOVA Fairfax Medical Campus ( Site 0136), Falls Church

22221

Clemenstorgets Hjartmottagning ( Site 3755), Lund

22500

Centro de Investigacion Cardiovascular y Metabólica ( Site 2465), Tijuana

23219

Dominion Medical Associates, Inc. ( Site 0089), Richmond

23507

Sentara Norfolk General Hospital ( Site 0114), Norfolk

24127

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 2151), Bergamo

25100

Hospital Tengku Ampuan Afzan ( Site 2353), Kuantan

25123

Azienda Ospedaliera Spedali Civili di Brescia-Cardiology- Day Hospital ( Site 2154), Brescia

26426

Yonsei University-Wonju Severance Christian Hospital ( Site 3555), Wŏnju

26480

Eskisehir Osmangazi University-Cardiology ( Site 4052), Eskişehir

27000

CIMAB SA de CV ( Site 2456), Torreón

27100

Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 2157), Pavia

28034

Hospital Universitario Ramón y Cajal ( Site 3662), Madrid

28040

Hospital Clinico San Carlos-Cardiology ( Site 3661), Madrid

28046

Hospital Universitario La Paz ( Site 3665), Madrid

28358

Southeastern Cardiology and Cardiovascular-Duke HC CRU - Lumberton ( Site 0134), Lumberton

28401

Accellacare - Wilmington ( Site 0090), Wilmington

28630

Centre Hospitalier Louis Pasteur ( Site 1360), Le Coudray

28644

Chungbuk National University Hospital-Internal medicine ( Site 3551), Cheongju-si

29001

Khmelnytskyi Regional Cardiovascular Center-department of invasive cardiology and interventional ra, Khmelnytskyi

29464

Accellacare - Charleston ( Site 0141), Charleston

30024

NSC Research ( Site 0068), Johns Creek

30322

Emory University School of Medicine ( Site 0123), Atlanta

30625

Medizinische Hochschule Hannover ( Site 1476), Hanover

31059

CHU Rangueil-Cardiology ( Site 1351), Toulouse

31201

Georgia Arrhythmia Consultants and Research Institute ( Site 0042), Macon

31203

Medivest Centro de Investigación Integral ( Site 2460), Chihuahua City

31792

Cardiovascular Consultants of South Georgia, LLC ( Site 0137), Thomasville

31904

IACT Health ( Site 0106), Columbus

32086

East Coast Institute for Research - St. Augustine ( Site 0016), Saint Augustine

32209

University of Florida - Jacksonville ( Site 0169), Jacksonville

32216

East Coast Institute for Research, LLC ( Site 0047), Jacksonville

33012

Indago Research and Health Center Inc ( Site 0011), Hialeah

33021

South Florida Research Solutions ( Site 0058), Hollywood

33166

Universal Axon Clinical Research, LLC ( Site 0022), Doral

33173

Cardiovascular Research Center of South Florida ( Site 0074), Miami

33175

ProLive Medical Research ( Site 0032), Miami

33308

Holy Cross Hospital ( Site 0100), Fort Lauderdale

33343

Mersin University ( Site 4056), Mersin

33434

Excel Medical Clinical Trials ( Site 0008), Boca Raton

33600

CHU Bordeaux Haut-Leveque ( Site 1362), Pessac

33952

Peace River Cardiovascular Center ( Site 0088), Port Charlotte

34098

Istanbul University Cerrahpasa Medical School Internal Diseases Institute-CARDIOLOGY INSTITUTE ( Sit, Istanbul

34149

Cattinara Hospital-Cardiovascular Department ( Site 2162), Trieste

34239

Cardiovascular Center of Sarasota ( Site 0154), Sarasota

34662

Başkent Üniversitesi Istanbul Hastanesi ( Site 4057), Istanbul

34668

Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 4063), Istanbul

34695

BAYCARE MEDICAL GROUP ( Site 0099), Safety Harbor

35010

Advanced Cardiovascular - Alexander City ( Site 0038), Alexander City

35015

Chungnam national university hospital ( Site 3554), Junggu

35100

Ege University Medicine of Faculty-Cardilogy Department ( Site 4054), Bornova

35294

University of Alabama at Birmingham - School of Medicine-Cardiology ( Site 0153), Birmingham

35340

Dokuz Eylül Üniversitesi-CARDIOLOGY ( Site 4055), Izmir

35510

Medical Park zmir Hastanesi-cardiology ( Site 4059), Izmir

35801

Heart Center Research, LLC ( Site 0156), Huntsville

37232

Vanderbilt University Medical Center-Vanderbilt Heart and Vascular Institue ( Site 0060), Nashville

38301

Apex Research Foundation ( Site 0001), Jackson

39209

Phillips Medical Services ( Site 0070), Jackson

39216

The University of Mississippi Medical Center-Cardiovascular ( Site 0073), Jackson

39901

Hospital General de Acapulco ( Site 2469), Acapulco de Juárez

40138

IRCCS - AOU di Bologna-Dept. of Medical and Surgical sciences ( Site 2158), Bologna

40205

Norton Healthcare-Norton Heart Specialist ( Site 0062), Louisville

41014

Hospital Universitario Virgen de Valme ( Site 3654), Seville

41063

Kliniken Maria Hilf-Klinik für Kardiologie ( Site 1454), Mönchengladbach

41380

Kocaeli Üniversitesi-Cardiology ( Site 4060), Kocaeli

42000

Grupo Ollin Care ( Site 2476), Pachuca

43024

Lutsk City Clinical Hospital-Center for Cardiovascular Disease ( Site 4255), Lutsk

43606

ProMedica Toledo Hospital-ProMedica Heart Failure Clinic ( Site 0061), Toledo

44001

KardioBusak s.r.o. ( Site 1051), Louny

44124

Azienda Ospedaliero Universitaria S.Anna ( Site 2152), Cona

44150

Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente ( Site 2466), Guadalajara

44160

Cardiocent de Guadalajara S.C. ( Site 2464), Guadalajara

44670

Instituto Jalisciense de Metabolismo SC ( Site 2467), Guadalajara

44710

Aultman Hospital-Cardiology Clinical Trials ( Site 0064), Canton

45219

University of Cincinnati Medical Center-Cardiology ( Site 0071), Cincinnati

46010

HOSPITAL CLINICO DE VALENCIA ( Site 3656), Valencia

46237

Franciscan Physician Network - Indiana Heart Physicians ( Site 0087), Indianapolis

46321

Cardiovascular Research of Northwest Indiana ( Site 0036), Munster

46410

The Heart Center of Lake County Research Institute-Research ( Site 0147), Merrillville

47000

UiTM Sungai Buloh Campus ( Site 2354), Sungai Buloh

47374

Reid Physician Associates ( Site 0054), Richmond

48075

Ascension Providence Hospital ( Site 0094), Southfield

49100

Rabin Medical Center-Cardiology - CHF ( Site 2052), Petah Tikva

49241

Pusan National University Hospital-Internal Medicine ( Site 3553), Busan

50006

Changhua Christian Hospital ( Site 3857), Changhua County

50030

Rodrigo Botero S.A.S ( Site 0953), Medellín

50733

St. Vinzenz-Hospital-Cardiology ( Site 1455), Cologne

51375

Klinikum Leverkusen ( Site 1453), Leverkusen

52242

University of Iowa ( Site 0005), Iowa City

53100

ospedale le scotte ( Site 2163), Siena

54511

Centre Hospitalier Régional Universitaire de Nancy - Hôpitau-Centre Investigation Clinique Plurithé, Vandœuvre-lès-Nancy

56564

Marienhaus Klinikum St. Elisabeth Neuwied ( Site 1452), Neuwied

57001

European Interbalkan Medical Center-2nd Department of Cardiology ( Site 1557), Thessaloniki

57072

Gemeinschaftspraxis Dr. Fabian Krämer, Dr. Ulrich Overhoff ( Site 1459), Siegen

59100

University Malaya Medical Centre ( Site 2351), Lembah Pantai

59901

Logan Health Research ( Site 0017), Kalispell

60200

Fakultni Nemocnice u sv. Anny v Brne-I. interni kardioangiologicka klinika ( Site 1066), Brno

60429

Chicago Medical Research ( Site 0086), Hazel Crest

60596

ClinPhenomics CVC GmbH ( Site 1457), Frankfurt am Main

60608

Mount Sinai Hospital ( Site 0050), Chicago

61000

Central clinical hospital - Ukrzalisnytsia-2nd Cardiology ( Site 4306), Kharkiv

"Communal non-profit enterprise City Clinical Hospital # 27 of Kharkiv City Council ( Site 4262)", Kharkiv

61039

L.T. Mala National Institute of Therapy of NAMS of Ukraine-Clinical Pharmacology and Pharmacogeneti, Kharkiv

61176

Municipal Non-Profit Enterprise -City clinical hospital No8 of Kharkiv city council ( Site 4278), Kharkiv

61469

Chonnam National University Hospital ( Site 3558), Gwangju

61614

OSF Healthcare Cardiovascular Institute ( Site 0122), Peoria

61636

Methodist Medical Center of Illinois ( Site 0098), Peoria

63110

Washington University-Department of Medicine ( Site 0044), St Louis

63136

St. Louis Heart and Vascular, P.C.-Clinical Trials Unit ( Site 0029), St Louis

63225

Asklepios Klinik Langen ( Site 1473), Langen

64460

Unidad biomedica avanzada monterrey ( Site 2462), Monterrey

65025

Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 42, Odesa

65212

University of Missouri Hospital ( Site 0163), Columbia

65929

Klinikum Frankfurt Höchst ( Site 1463), Frankfurt am Main

66465

Unidad Médica para la Salud Integral ( Site 2472), San Nicolás de los Garza

66902

KIGE ( Site 1060), Znojmo

67063

Klinikum Ludwigshafen ( Site 1456), Ludwigshafen am Rhein

67207

Alliance for Multispecialty Research, LLC ( Site 0143), Wichita

68000

Oaxaca Site Management Organization ( Site 2459), Oaxaca City

68020

Centro de Investigacion Clinica de Oaxaca ( Site 2457), Oaxaca City

69035

"Communal Non-profit Enterprise City Hospital #6 Zaporizhzhia City Counci-Therapy department ( Site", Zaporizhia

69065

"Communal nonprofit enterprise City Hospital #9 of Zaporizhzhia City Council ( Site 4251)", Zaporizhia

69120

Universitaetsklinikum Heidelberg-Klinik für Kardiologie, Angiologie und Pneumologie ( Site 1475), Heidelberg

69677

Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1364), Lyon

70360

Cardiovascular Institute of the South ( Site 0072), Houma

70403

Louisiana Heart Center - Hammond ( Site 0004), Hammond

The Heart Clinic - Hammond ( Site 0155), Hammond

70503

Cardiovascular Institute of the South, 3 ( Site 0096), Lafayette

70570

Cardiovascular Institute of the South ( Site 0081), Opelousas

71201

IMA Clinical Research ( Site 0112), Monroe

71301

Cambridge Medical Trials ( Site 0041), Alexandria

72189

Västmanlands Sjukhus Västerås ( Site 3757), Västerås

75013

Pitie Salpetriere University Hospital ( Site 1363), Paris

75216

Dallas VA Medical Center ( Site 0084), Dallas

75235

Southwest Family Medicine Associates ( Site 0131), Dallas

75701

Tyler Cardiovascular Consultants ( Site 0039), Tyler

76000

"Clinical medical and diagnostic center Limited Liability Company Simedgroup ( Site 4284)", Ivano-Frankivsk

76018

"Municipal Non-commercial Enterprise Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Fr", Ivano-Frankivsk

76031

CHU Charles Nicolle ( Site 1354), Rouen

77094

West Houston Area Clinical Trial Consultants ( Site 0014), Houston

78028

South Texas Cardiovascular Consultants, PLLC-Research ( Site 0024), Kerrville

78200

Centro de Atención e Investigación Cardiovascular del Potosí ( Site 2453), San Luis Potosí City

78201

South Texas Cardiovascular Consultants, PLLC-Research ( Site 0020), San Antonio

79935

Medresearch Inc ( Site 0043), El Paso

82113

Centro de Estudios de Alta Especialidad de Sinaloa ( Site 2463), Mazatlán

83100

Centre Hospitalier intercommunal de Toulon La Seyne sur Mer ( Site 1352), Toulon

85000

CHD Vendee ( Site 1361), La Roche-sur-Yon

85297

Mercy Gilbert Medical Center-Dignity Health Cardiology ( Site 0075), Gilbert

88000

Zakarpattya Regional Clinical Cardiology Dispensary-Dept. of Hospital Therapy, Uzhhorod National Un, Uzhhorod

88300

Hospital Queen Elizabeth II ( Site 2359), Kota Kinabalu

89440

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 2468), Ciudad Madero

89502

Renown Regional Medical Center-Renown Institute for Heart and Vascular Health ( Site 0168), Reno

90073

VA West Los Angeles Medical Center-Cardiology ( Site 0149), Los Angeles

90402

Kardiologische Gemeinschaftspraxis ( Site 1460), Nuremberg

90502

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0010), Torrance

91193

Consultorio de Medicina Especilizada del Sector Privado ( Site 2455), Xalapa

Hospital Angeles Xalapa ( Site 2451), Xalapa

91325

Valley Clinical Trials Inc ( Site 0006), Northridge

91723

Valley Clinical Trials, Inc. ( Site 0085), Covina

92081

Blue Coast Research Center ( Site 0053), Vista

94270

Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 1356), Le Kremlin-Bicêtre

94300

Sarawak Heart Centre ( Site 2352), Kota Samarahan

97070

Medical Care and Research SA de CV ( Site 2461), Mérida

97080

Universitaetsklinikum Wuerzburg ( Site 1458), Würzburg

98372

Pulse Heart Institute - Puyallup ( Site 0119), Puyallup

99097

Katholisches Krankenhaus St. Johann Nepomuk ( Site 1462), Erfurt

99204

MultiCare Health System-MultiCare Cardiology - Inland Northwest ( Site 0102), Spokane

100029

Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 0856), Beijing

100049

Aero Space Center Hospital ( Site 0918), Beijing

100050

Beijing Friendship Hospital-Cardology ( Site 0865), Beijing

102218

Beijing Tsinghua Changgung Hospital ( Site 0911), Beijing

110016

The People's Hospital of Liaoning Province ( Site 0859), Shenyang

117292

"State budgetary Healthcare Institution of the city of Moscow V. V. Vinogradov City Clinical Hospita", Moscow

119074

National University Heart Centre, Singapore-Department of Cardiology ( Site 3355), Singapore

130033

China-Japan Union Hospital-department of cardiology ( Site 0916), Changchun

136000

Siping Central People's Hospital-Cardiovascular Department ( Site 0915), Siping

150001

The First Hospital of Harbin Medical University-Cardiology ( Site 0903), Harbin

153012

Ivanovo Regional Healthcare Institution Cardiology Dispensary ( Site 3265), Ivanovo

169609

National Heart Centre Singapore ( Site 3351), Singapore

170004

IPS Médicos Internistas de Caldas ( Site 0959), Manizales

196084

Institute for Medical Research ( Site 3316), Saint Petersburg

197022

First Pavlov State Medical University of Saint Petersburg-Сardiology department ( Site 3257), Saint Petersburg

First Pavlov State Medical University of Saint Petersburg ( Site 3288), Saint Petersburg

197341

Almazov National Medical Research Centre ( Site 3320), Saint Petersburg

199106

Pokrovskaya Municipal Hospital ( Site 3252), Saint Petersburg

Pokrovskaya Municipal Hospital-1-st cardiology department ( Site 3251), Saint Petersburg

199226

Astarta Clinic ( Site 3276), Saint Petersburg

200001

Shanghai Jiaotong University School of Medicine Ruijin Hospital-Cardiology Department ( Site 0855), Shanghai

200032

Zhongshan Hospital,Fudan University-Cardiology ( Site 0851), Shanghai

200065

Shanghai Tongji Hospital-Cardiovascular Department ( Site 0905), Shanghai

200090

Shanghai Yangpu District Central Hospital-Cardiology ( Site 0876), Shanghai

210000

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Cardiolggy, Nanjing

210011

The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 0900), Nanjing

212001

Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 0917), Zhenjiang

214002

Wuxi No.2 People's Hospital-Cardiology Department ( Site 0877), Wuxi

214023

Wuxi People's Hospital-Cardiovascular Department ( Site 0870), Wuxi

221006

The Affiliated Hospital of Xuzhou Medical College ( Site 0910), Xuzhou

225001

Northern Jiangsu People's Hospital ( Site 0861), Yangzhou

230036

Anhui Provincil Hospital South District ( Site 0920), Hefei

300211

The Second Hospital of Tianjin Medical University-Endocrinology ( Site 0902), Tianjin

300222

Tianjin Chest Hospital-Cardiology ( Site 0901), Tianjin

308433

Tan Tock Seng Hospital ( Site 3353), Singapore

310003

The First Affiliated Hospital, Zhejiang University ( Site 0907), Hangzhou

310052

The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0909), Hangzhou

311599

Zhejiang Provincial People's Hospital ( Site 0914), Hangzhou

323000

People's Hospital of Lishui City-department of cardiovascular ( Site 0862), Lishui

325000

The First Affiliated Hospital of Wenzhou Medical University-Vasculocardiology Department ( Site 0874, Wenzhou

330006

The Second Affiliated Hospital of Nanchang University-Cardiology ( Site 0912), Nanchang

344022

Rostov State Medical University ( Site 3259), Rostov-on-Don

344068

Rostov-on-Don City Emergency Hospital ( Site 3271), Rostov-on-Don

350086

Krasnodar Regional Clinical Hospital Number 1 S.V. Ochapovskogo ( Site 3281), Krasnodar

354057

City Hospital No. 4 ( Site 3269), Sochi

390005

Ryazan State Medical University named after Academician I.P. Pavlova ( Site 3260), Ryazan

400010

The Second Affiliated Hospital Chongqing Medical University-Department of Cardiology ( Site 0908), Chongqing

400131

Volgograd State Medical University ( Site 3258), Volgograd

404199

Chongqing Three Gorges Central Hospital ( Site 0913), Wanzhou

410004

Changsha Central Hospital ( Site 0854), Changsha

410005

Hunan Provincial People's Hospital ( Site 0857), Changsha

410008

Xiangya Hospital Central South University-Cardiological Department ( Site 0899), Changsha

410013

The Third Xiangya Hospital of Central South University-Cardiology ( Site 0860), Changsha

410054

Clinical Hospital S.R.Mirotvortseva name SSMU ( Site 3254), Saratov

420101

Interregional Clinical Diagnostic Center-Department of Clinical Trials ( Site 3307), Kazan'

430022

Wuhan Union Hospital ( Site 0919), Wuhan

510080

Guangdong Provincial People's Hospital-Cardiology ( Site 0852), Guangzhou

510120

Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Cardiology ( Site 0868), Guangzhou

510630

The First Affiliated Hospital of Jinan University ( Site 0897), Guangzhou

518053

The University of Hong Kong - Shenzhen Hospital-Cardiovascular department ( Site 0895), Shenzhen

528041

The First People's Hospital of Foshan ( Site 0898), Foshan

529889

Changi General Hospital ( Site 3356), Singapore

570311

Hainan General Hospital ( Site 0894), Haikou

609300

Yitzhak Shamir Medical Center-Cardiology ( Site 2060), Ẕerifin

610041

West China Hospital Sichuan University ( Site 0904), Chengdu

614990

Perm Regional Hospital for War Veterans ( Site 3272), Perm

644018

Omsk Regional Clinical Health Service Number 9 ( Site 3296), Omsk

680002

Instituto Del Corazón De Bucaramanga ( Site 0960), Bucaramanga

681017

Fundación Cardiovascular de Colombia ( Site 0961), Piedecuesta

710061

The First Affiliated Hospital of Xian Jiaotong University ward1 depattment of medical oncology ( Sit, Xi'an

710068

Shaanxi provincial people's hospital ( Site 0853), Xi'an

730030

Lanzhou university second hospital-Lanzhou university second hospital ( Site 0863), Lanzhou

760032

Fundacion Valle del Lili- CIC-Internal Medicine ( Site 0962), Santiago de Cali

760036

Centro de Investigaciones Clinicas SAS ( Site 0957), Santiago de Cali

999077

Grantham Hospital ( Site 1753), Aberdeen

1720430

IC La Serena Research ( Site 0769), La Serena

2210001

Galilee Medical Center-Cardiology ( Site 2051), Nahariya

2520598

ONCOCENTRO APYS ( Site 0770), Viña del Mar

3109601

Rambam Health Care Campus-Cardiology ( Site 2053), Haifa

3810101

Hillel Yaffe Medical Center-Heart Institute ( Site 2058), Hadera

4780000

Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0752), Temuco

5110683

Clinical Research Chile SpA ( Site 0761), Valdivia

5262100

Sheba Medical Center-Leviev Heart Center ( Site 2064), Ramat Gan

5311089

Clinica Alemana Osorno ( Site 0768), Osorno

7500587

Enroll SpA ( Site 0755), Santiago

7610001

Kaplan Medical Center-Heart Institution ( Site 2054), Rehovot

7640881

Clinica Dermacross ( Site 0760), Santiago

7747629

Assuta Ashdod Medical Center-Cardiology ( Site 2063), Ashdod

7770086

Espacio Eme ( Site 0762), Santiago

8053095

Hospital y CRS El Pino ( Site 0763), Santiago

8330111

Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0754), Santiago

8380465

Clínica Ensenada ( Site 0753), Santiago

8910259

Cardio Sur ( Site 0756), Santiago

9013102

Shaare Zedek Medical Center-Cardiology ( Site 2055), Jerusalem

9112001

Hadassah Medical Center-Heart Institute ( Site 2062), Jerusalem

14048900

Hospital de Clínicas de Ribeirão Preto ( Site 0559), Ribeirão Preto

08869

Amici Clinical Research LLC-Research ( Site 0037), Raritan

07450

The Valley Hospital ( Site 0035), Ridgewood

08080

Cardiovascular Associates of the Delaware Valley ( Site 0097), Washington Township

10029-5674

Icahn School of Medicine at Mount Sinai ( Site 0161), New York

C1060ABN

CEDIC ( Site 4363), CABA

C1027AAP

Centro de Investigaciones Metabólicas (CINME)-Cardiology ( Site 4352), Ciudad Autónoma de Buenos Aires

B1704ETD

DIM Clínica Privada ( Site 4359), Ramos Mejía

B2800DGH

Instituto de Investigaciones Clinicas Zarate ( Site 4360), Zárate

C1120AAC

Centro Médico Viamonte-Clinical Research ( Site 4361), Buenos Aires

S2000DEJ

Fundacion Estudios Clinicos ( Site 4356), Rosario

A-1190

Imed19-privat ( Site 0353), Vienna

60864-190

Hospital de Messejana Dr Carlos Alberto Studart Gomes ( Site 0560), Fortaleza

74605-020

Universidade Federal de Goias-Serviço de Cardiologia ( Site 0553), Goiânia

Unknown

PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR ( Site 0555), Curitiba

Shanghai Xuhui Central Hospital-Cardiovascular Department ( Site 0872), Shanghai

Tianjin People' s Hospital ( Site 0867), Tianjin

Clínica Imbanaco S.A.S ( Site 0963), Santiago de Cali

Klinikum Coburg ( Site 1464), Coburg

Unidad De Diagnostico Cardiologico ( Site 1654), Guatemala City

Queen Mary Hospital-Medicine - Cardiology ( Site 1752), Hksar

Princess Margaret Hospital ( Site 1755), Hong Kong

90880-480

Hospital Mae de Deus ( Site 0564), Porto Alegre

49055-530

Centro de Pesquisa Clinica do Coracao ( Site 0561), Acaraju

13060-080

Instituto de Pesquisa clinica de Campinas ( Site 0551), Campinas

14026-900

CAPED Centro Avancado Pesquisa e Diagnostica ( Site 0552), Ribeirão Preto

22280-003

Hospital Pro-Cardiaco ( Site 0556), Rio de Janeiro

05403-900

Incor - Instituto do Coracao ( Site 0557), São Paulo

T2N 4Z6

Heritage Medical Research Clinic ( Site 0679), Calgary

T6G 2B7

University Of Alberta Hospital ( Site 0669), Edmonton

V8R 1B2

Victoria Heart Institute Foundation ( Site 0680), Victoria

R2H 2A6

St. Boniface General Hospital ( Site 0667), Winnipeg

E1G 1A7

G A Research Associates ( Site 0652), Moncton

B3H 3A7

NSHA-QEII Health Sciences Centre-Dickson Bldg-Cardiology ( Site 0664), Halifax

N1R 6V6

Cambridge Cardiac Care Centre ( Site 0658), Cambridge

L3Y 2P6

PACE Cardiology ( Site 0675), Newmarket

M6B 3H7

North York Diagnostic and Cardiac Centre ( Site 0682), North York

L6K 3W7

Oakville Cardiovascular Research LP ( Site 0657), Oakville

L1J 2K1

Private Practice - Dr. James Cha ( Site 0655), Oshawa

K9J 0B2

Kawartha Cardiology Clinical Trials ( Site 0654), Peterborough

M1B 5N1

Corcare-Corcare Cardiovascular Research ( Site 0660), Toronto

M4P 1E4

Medicus MFC Research Clinic ( Site 0676), Toronto

H7M 3L9

Hôpital de la Cité-de-la-Santé ( Site 0673), Laval

H1T 1C8

Institut de Cardiologie de Montreal ( Site 0661), Montreal

H3G 1A4

Montreal General Hospital ( Site 0653), Montreal

J7Z 2V4

Unité de Recherche Clinique du CISSS des Laurentides ( Site 0668), Saint-Jérôme

J1H 5N4

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer, Sherbrooke

J6V 2H2

Hopital Pierre-Le Gardeur ( Site 0674), Terrebonne

G9A 4P3

Diex Recherche Trois-Rivieres ( Site 0677), Trois-Rivières

014040

BAO TOU CENTRAL HOSPITAL ( Site 0866), Baotou

050021

Fundación Centro de Investigación Clínica CIC ( Site 0955), Medellín

050034

Centro Cardiovascular Colombiano Clínica Santa María ( Site 0951), Medellín

080020

Clinica de la Costa S.A.S. ( Site 0954), Barranquilla

Corazon IPS ( Site 0964), Barranquilla

IPS Centro Científico Asistencial S.A.S ( Site 0952), Barranquilla

625 00

Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 1058), Brno

636 00

Vojenská Nemocnice Brno-Internal department ( Site 1055), Brno

274 01

Nemocnice Slany-Interna - kardiologicka ambulance ( Site 1063), Slaný

293 01

Klinika Dr. Pirka ( Site 1065), Mladá Boleslav

169 02

Ustredni vojenska nemocnice-Oddeleni kardiologie ( Site 1054), Prague

602 00

MUDr. Libor Nechvatal s.r.o. , Kardiologie ( Site 1057), Brno

06000

Centre Hospitalier Universitaire de Nice - Hopital Pasteur-Service cardiologie ( Site 1353), Nice

01067

Staedtisches Klinikum Dresden-2. Medizinische Klinik ( Site 1468), Dresden

01277

Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien ( Site 1477), Dresden

01307

Herzzentrum Dresden GmbH Universitätsklinik ( Site 1469), Dresden

115 27

General Hospital of Athens Hippokratio ( Site 1552), Athens

115 28

Alexandra Hospital-HEART FAILURE AND CARDIO-ONCOLOGY UNIT ( Site 1559), Athens

142 33

Konstantopoulio General Hospital-Cardiology Clinic ( Site 1553), Athens

124 62

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1556), Chaïdári

151 23

Hygeia Hospital-6th cardiology clinic ( Site 1560), Marousi

681 00

University Hospital of Alexandroupolis-First Department of Internal Medicine ( Site 1551), Alexanroupolis

411 10

University General Hospital of Larissa ( Site 1555), Larissa

455 00

University Hospital of Ioannina-2nd Department of Cardiology ( Site 1554), Ioannina

546 36

AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 1558), Thessaloniki

01001

Unidad De Diagnostico Cardiologico ( Site 1652), Guatemala City

01010

Clinica Medica ( Site 1651), Guatemala City

NT

Prince of Wales Hospital ( Site 1751), Shatin

A96 D628

St. Michael's Hospital ( Site 1955), Dún Laoghaire

D08 E9P6

St. James's Hospital-Cardiology ( Site 1951), Dublin

00161

Policlinico Umberto I ( Site 2166), Rome

00163

IRCCS San Raffaele Pisana-riabilitazione cardiologica ( Site 2156), Rome

06132

University of Perugia ( Site 2164), Perugia

05460

Hospital Sultanah Bahiyah-Department of Cardiology ( Site 2355), Alor Star

06720

HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA ( Site 2478), Mexico City

0622

North Shore Hospital-Cardiology Research ( Site 2656), Auckland

07011

Hospital Alberto Sabogal Sologuren ( Site 2851), Bellavista

Lima 31

Hospital Cayetano Heredia-Servicio de cardiologia ( Site 2852), Lima

85-231

NZOZ Centrum Medyczne KERmed ( Site 3066), Bydgoszcz

87-100

Praktyka Lekarska Lidia Pawlowicz ( Site 3053), Torun

Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu-Oddz.Klin.Kardiologii i Int.T.Kard. ( Si, Torun

32-500

Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 3062), Chrzanów

31-216

Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Sp. J. ( Site 3061), Krakow

33-100

"Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych METABOLICA Lek. Robert Witek ( Site", Tarnów

59-220

Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 3070), Legnica

50-556

Instytut Chorób Serca, Zakład Badań Klinicznych Chorób Układu Krążenia ( Site 3057), Wrocaw

20-857

NZOZ Twoja Przychodnia ( Site 3051), Lublin

24-100

SP ZOZ w Puławach- Oddział Kardiologii ( Site 3071), Puławy

02-793

ETG Warszawa ( Site 3052), Warsaw

47-200

Polsko-Amerykańskie Kliniki Serca ( Site 3077), Kędzierzyn-Koźle

35-055

Centrum Medyczne Medyk ( Site 3065), Rzeszów

16-100

Centrum Medyczne Dr Sudnik s.c. Wanda i Jerzy Sudnik ( Site 3073), Sokółka

81-157

Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman, Gdynia

00961

Cooperativa De Facultad Medica Sanacoop-Instituto Sanacoop ( Site 3151), Bayamón

00791

Private Practice - Dr. Yolanda Figueroa-Torres ( Site 3156), Humacao

00717

Research and Cardiovascular Corp. ( Site 3152), Ponce

00745

Caparra Internal Medicine ( Site 3155), Río Grande

00921-3201

VA Caribbean Healthcare System ( Site 3157), San Juan

0001

University of Pretoria - Faculty of Health Sciences-CRU ( Site 3462), Pretoria

0186

Clinical Trial Systems ( Site 3452), Pretoria

0183

Jongaie Research ( Site 3469), Pretoria West

03080

Seoul National University Hospital ( Site 3557), Seoul

03722

Severance Hospital, Yonsei University Health System ( Site 3552), Seoul

08916

Hospital Germans Trias i Pujol ( Site 3664), Badalona

08023

Hospital Quiron Barcelona ( Site 3655), Barcelona

08907

Hospital Universitari de Bellvitge-Unitat Multidisciplinar d'Insuficiència Cardíaca Comunitària (UM, L'Hospitalet de Llobregat

08003

Parc de Salut Mar - Hospital del Mar ( Site 3663), Barcelona

08035

Hospital Universitari Vall d'Hebron ( Site 3659), Barcelona

791 31

Falu Lasarett-Dep of Cardiology ( Site 3756), Falun

171 64

Karolinska Universitetssjukhuset Solna-Heart and Vascular theme ( Site 3759), Solna

113 61

Aleris Specialistvård Sabbatsberg ( Site 3762), Stockholm

117 27

Akardo Med Site ( Site 3763), Stockholm

931 86

Skellefteå Lasarett-Research unit, floor 5 ( Site 3760), Skellefteå

413 45

Sahlgrenska Universitetssjukhuset-Cardiology Research Unit ( Site 3753), Gothenburg

701 85

Universitetssjukhuset Örebro-Heart-Lung-Physiology Clinic ( Site 3754), Örebro

03200

Afyon Kocatepe Üniversitesi Tıp Fakültesi-Cardiology Department ( Site 4058), Afyonkarahisar

06230

Hacettepe Universitesi ( Site 4061), Ankara

06800

Ankara Bilkent Şehir Hastanesi-cardiology ( Site 4053), Ankara

07100

Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 4064), Antalya

03049

Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain, Kiev

04050

"Medical Center of Limited Liability Company Medical Center Consilium Medical ( Site 4257)", Kiev

03037

Medbud Clinic ( Site 4265), Kyiv

03680

State Institution National Scientific Center M.D. Strazhesko-Essential Hypertension ( Site 4259), Kyiv

State Institution National Scientific Center M.D. Strazhesko-Resuscitation and Intensive care ( Site, Kyiv

01103

Consultative - Diagnostic Centre of Pechersky District-Therapeutic department ( Site 4307), Kyiv

02166

"MNE Kyiv City Clinical Emergency Hospital of Kyiv Regional Council (KCSA) ( Site 4256)", Kyiv

03151

State Institution National Scientific Center M.D. Strazhesko-Department of clinical arrhythmology a, Kyiv

CA2 7HY

Cumberland Infirmary ( Site 4174), Carlisle

CA28 8JG

West Cumberland Hospital ( Site 4176), Whitehaven

S44 5BL

Chesterfield Royal Hospital ( Site 4159), Calow Chesterfield

DD1 9SY

Ninewells Hospital and Medical School-Cardiology ( Site 4164), Dundee

DL3 7RD

Carmel Medical Practice ( Site 4152), Darlington

DY1 2HQ

Russells Hall Hospital ( Site 4153), Dudley

SE5 9RS

King's College Hospital-Cardiac Research Department ( Site 4154), London

SW17 0QT

St. George's Hospital-Cardiology Clinical Academic Group ( Site 4156), London

CF47 9DT

Prince Charles Hospital ( Site 4171), Merthyr Tydfil

FY3 7EN

Layton Medical Centre ( Site 4184), Blackpool

BT16 1RH

Ulster Hospital ( Site 4185), Belfast

EC1M 5PZ

William Harvey Heart Centre ( Site 4169), London

BT63 5QQ

Craigavon Area Hospital ( Site 4162), Belfast

CF31 1RQ

Princess of Wales Hospital ( Site 4178), Bridgend

WS2 9PS

Walsall Manor Hospital ( Site 4179), West Midlands

WR5 1DD

Worcestershire Royal Hospital-Cardiology Research Department ( Site 4181), Worcester

FY3 8NR

Blackpool Victoria Hospital ( Site 4161), Blackpool

CV2 2DX

University Hospital Coventry & Warwickshire-Research & Development ( Site 4170), Coventry

BH16 5PW

The Adam Practice ( Site 4180), Poole

TS19 8PE

University Hospital of North Tees ( Site 4172), Stockton-on-Tees

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT05093933 - A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035) | Biotech Hunter | Biotech Hunter