654
Participants
Start Date
June 3, 2022
Primary Completion Date
December 10, 2025
Study Completion Date
December 10, 2025
Avelumab
Given IV
Biospecimen Collection
Undergo collection of blood and urine samples
Bone Scan
Undergo bone scan
Cabozantinib S-malate
Given PO
Computed Tomography
Undergo CT
Magnetic Resonance Imaging
Undergo MRI
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
Memorial Sloan Kettering Cancer Center, New York
Memorial Sloan Kettering Westchester, Harrison
Memorial Sloan Kettering Nassau, Uniondale
Memorial Sloan Kettering Commack, Commack
Stony Brook University Medical Center, Stony Brook
Glens Falls Hospital, Glens Falls
Upstate Cancer Center at Oswego, Oswego
State University of New York Upstate Medical University, Syracuse
SUNY Upstate Medical Center-Community Campus, Syracuse
Upstate Cancer Center at Verona, Verona
Arnot Ogden Medical Center/Falck Cancer Center, Elmira
Penn State Health Medical Group - Andrews Patel Hematology/Oncology East, Harrisburg
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Lehigh Valley Hospital-Cedar Crest, Allentown
Thomas Jefferson University Hospital, Philadelphia
Jefferson Methodist Hospital, Philadelphia
Helen F Graham Cancer Center, Newark
Medical Oncology Hematology Consultants PA, Newark
Beebe South Coastal Health Campus, Millville
Beebe Health Campus, Rehoboth Beach
MedStar Washington Hospital Center, Washington D.C.
National Institutes of Health Clinical Center, Bethesda
Shenandoah Oncology PC, Winchester
Bon Secours Saint Francis Medical Center, Midlothian
Bon Secours Memorial Regional Medical Center, Mechanicsville
Bon Secours Saint Mary's Hospital, Richmond
Virginia Cancer Institute, Richmond
VCU Massey Cancer Center at Stony Point, Richmond
VCU Massey Comprehensive Cancer Center, Richmond
VCU Community Memorial Health Center, South Hill
West Virginia University Charleston Division, Charleston
Wake Forest University Health Sciences, Winston-Salem
Southeastern Medical Oncology Center-Goldsboro, Goldsboro
Atrium Health Cabarrus/LCI-Concord, Concord
Atrium Health Lincoln/LCI-Lincolnton, Lincolnton
Atrium Health Cleveland/LCI-Cleveland, Shelby
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Levine Cancer Institute-SouthPark, Charlotte
Atrium Health University City/LCI-University, Charlotte
Levine Cancer Institute-Ballantyne, Charlotte
Southeastern Medical Oncology Center-Clinton, Clinton
Southeastern Medical Oncology Center-Jacksonville, Jacksonville
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Medical University of South Carolina, Charleston
Prisma Health Cancer Institute - Butternut, Greenville
Prisma Health Cancer Institute - Faris, Greenville
Prisma Health Greenville Memorial Hospital, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Prisma Health Cancer Institute - Easley, Easley
Prisma Health Cancer Institute - Greer, Greer
Prisma Health Cancer Institute - Seneca, Seneca
Levine Cancer Institute-Rock Hill, Rock Hill
University of Florida Health Science Center - Gainesville, Gainesville
Cleveland Clinic-Weston, Weston
University Cancer Specialists - Alcoa, Alcoa
University of Tennessee - Knoxville, Knoxville
Baptist Health Louisville, Louisville
Toledo Clinic Cancer Centers-Toledo, Toledo
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
South Pointe Hospital, Warrensville Heights
Hillcrest Hospital Cancer Center, Mayfield Heights
Cleveland Clinic Cancer Center Strongsville, Strongsville
Cleveland Clinic Foundation, Cleveland
Cleveland Clinic Akron General, Akron
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster
North Coast Cancer Care, Sandusky
Cleveland Clinic Cancer Center Mansfield, Mansfield
Miami Valley Cancer Care and Infusion, Greenville
Upper Valley Medical Center, Troy
Premier Blood and Cancer Center, Dayton
Dayton Physician LLC - Englewood, Dayton
Miami Valley Hospital North, Dayton
Kettering Medical Center, Kettering
Miami Valley Hospital South, Centerville
Northwest Cancer Center - Main Campus, Crown Point
Northwest Oncology LLC, Dyer
Saint Catherine Hospital, Indianapolis
The Community Hospital, Munster
Women's Diagnostic Center - Munster, Munster
Northwest Cancer Center - Hobart, Hobart
Saint Mary Medical Center, Hobart
Northwest Cancer Center - Valparaiso, Valparaiso
Henry Ford Saint John Hospital - Macomb Medical, Macomb
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
Huron Gastroenterology PC, Ypsilanti
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
Trinity Health Medical Center - Brighton, Brighton
Chelsea Hospital, Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
Trinity Health Medical Center - Canton, Canton
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
Hope Cancer Center, Pontiac
Michigan Healthcare Professionals Pontiac, Pontiac
Newland Medical Associates-Pontiac, Pontiac
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
Hematology Oncology Consultants-Clarkston, Clarkston
Newland Medical Associates-Clarkston, Clarkston
Cancer Hematology Centers - Flint, Flint
Genesee Hematology Oncology PC, Flint
Genesys Hurley Cancer Institute, Flint
Hurley Medical Center, Flint
University of Michigan Health - Sparrow Lansing, Lansing
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Beacon Kalamazoo Cancer Center, Kalamazoo
Bronson Battle Creek, Battle Creek
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Trinity Health Muskegon Hospital, Muskegon
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
University of Michigan Health - West, Wyoming
Corewell Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
Mary Greeley Medical Center, Ames
McFarland Clinic - Ames, Ames
McFarland Clinic - Boone, Boone
McFarland Clinic - Jefferson, Jefferson
McFarland Clinic - Marshalltown, Marshalltown
McFarland Clinic - Trinity Cancer Center, Fort Dodge
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Aurora Health Care Germantown Health Center, Germantown
Aurora Cancer Care-Grafton, Grafton
Froedtert Menomonee Falls Hospital, Menomonee Falls
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
Aurora Medical Center in Summit, Summit
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend
Aurora Cancer Care-Southern Lakes VLCC, Burlington
Aurora Cancer Care-Kenosha South, Kenosha
ProHealth D N Greenwald Center, Mukwonago
Drexel Town Square Health Center, Oak Creek
ProHealth Waukesha Memorial Hospital, Waukesha
UW Cancer Center at ProHealth Care, Waukesha
Aurora Cancer Care-Milwaukee, Milwaukee
Aurora Saint Luke's Medical Center, Milwaukee
Medical College of Wisconsin, Milwaukee
Aurora Cancer Care-Milwaukee West, Wauwatosa
Aurora West Allis Medical Center, West Allis
Aurora Sinai Medical Center, Milwaukee
Aurora Cancer Care-Racine, Racine
Cancer Center of Western Wisconsin, New Richmond
Aurora Bay Area Medical Group-Marinette, Marinette
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
Aurora BayCare Medical Center, Green Bay
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Marshfield Medical Center - Minocqua, Minocqua
Marshfield Medical Center-EC Cancer Center, Eau Claire
Marshfield Medical Center-Rice Lake, Rice Lake
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
Regions Hospital, Saint Paul
Abbott-Northwestern Hospital, Minneapolis
Hennepin County Medical Center, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Mayo Clinic in Rochester, Rochester
Rice Memorial Hospital, Willmar
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud
Sanford Joe Lueken Cancer Center, Bemidji
Avera Cancer Institute at Yankton, Yankton
Sanford Cancer Center Oncology Clinic, Sioux Falls
Avera Cancer Institute, Sioux Falls
Avera Cancer Institute-Aberdeen, Aberdeen
Rapid City Regional Hospital, Rapid City
Sanford Broadway Medical Center, Fargo
Sanford Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Advocate Good Shepherd Hospital, Barrington
AMG Crystal Lake - Oncology, Crystal Lake
Northwestern Medicine Lake Forest Hospital, Lake Forest
AMG Libertyville - Oncology, Libertyville
Condell Memorial Hospital, Libertyville
Advocate Lutheran General Hospital, Park Ridge
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
Advocate Sherman Hospital, Elgin
Northwestern Medicine Cancer Center Delnor, Geneva
Advocate South Suburban Hospital, Hazel Crest
Rush-Copley Medical Center, Aurora
Advocate Good Samaritan Hospital, Downers Grove
Northwestern Medicine Cancer Center Warrenville, Warrenville
Rush-Copley Healthcare Center, Yorkville
Northwestern University, Chicago
Rush MD Anderson Cancer Center, Chicago
University of Illinois, Chicago
Advocate Illinois Masonic Medical Center, Chicago
Illinois CancerCare-Dixon, Dixon
UW Health Carbone Cancer Center Rockford, Rockford
Illinois CancerCare-Ottawa Clinic, Ottawa
Illinois CancerCare-Peru, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
Illinois CancerCare - Washington, Washington
Illinois CancerCare-Peoria, Peoria
Illinois CancerCare-Bloomington, Bloomington
Carle Cancer Center, Urbana
Carle at The Riverfront, Danville
Carle Physician Group-Mattoon/Charleston, Mattoon
Cancer Care Center of O'Fallon, O'Fallon
Memorial Hospital East, Shiloh
Illinois CancerCare-Carthage, Carthage
Carle Physician Group-Effingham, Effingham
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
Centralia Oncology Clinic, Centralia
Washington University School of Medicine, St Louis
Siteman Cancer Center-South County, St Louis
Siteman Cancer Center at Christian Hospital, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Saint Francis Medical Center, Cape Girardeau
Saint Luke's East - Lee's Summit, Lee's Summit
Saint Luke's Hospital of Kansas City, Kansas City
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia
University of Oklahoma Health Sciences Center, Oklahoma City
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa
UT Southwestern Clinical Center at Richardson/Plano, Richardson
UT Southwestern Simmons Cancer Center - RedBird, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth
Mayo Clinic Hospital in Arizona, Phoenix
University of New Mexico Cancer Center, Albuquerque
Memorial Medical Center-Las Cruces, Las Cruces
OptumCare Cancer Care at Seven Hills, Henderson
OptumCare Cancer Care at Charleston, Las Vegas
OptumCare Cancer Care at Fort Apache, Las Vegas
Palo Alto Medical Foundation-Camino Division, Mountain View
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
California Pacific Medical Center-Pacific Campus, San Francisco
Palo Alto Medical Foundation Health Care, Palo Alto
Palo Alto Medical Foundation-Fremont, Fremont
Sutter Solano Medical Center/Cancer Center, Vallejo
Alta Bates Summit Medical Center-Herrick Campus, Berkeley
Palo Alto Medical Foundation-Santa Cruz, Santa Cruz
Memorial Medical Center, Modesto
Sutter Auburn Faith Hospital, Auburn
Sutter Roseville Medical Center, Roseville
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Legacy Mount Hood Medical Center, Gresham
Legacy Meridian Park Hospital, Tualatin
Legacy Good Samaritan Hospital and Medical Center, Portland
Valley Medical Center, Renton
Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver
Legacy Salmon Creek Hospital, Vancouver
Mayo Clinic in Florida, Jacksonville
Advocate Christ Medical Center, Oak Lawn
Harold Alfond Center for Cancer Care, Augusta
UMass Memorial Medical Center - University Campus, Worcester
New Hampshire Oncology Hematology PA-Concord, Concord
Solinsky Center for Cancer Care, Manchester
Memorial Sloan Kettering Basking Ridge, Basking Ridge
Hackensack University Medical Center, Hackensack
Memorial Sloan Kettering Monmouth, Middletown
Memorial Sloan Kettering Bergen, Montvale
Morristown Medical Center, Morristown
Saint Joseph's Regional Medical Center, Paterson
Overlook Hospital, Summit
Atrium Medical Center-Middletown Regional Hospital, Franklin
Penn State Milton S Hershey Medical Center, Hershey
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Cross Cancer Institute, Edmonton
University Health Network-Princess Margaret Hospital, Toronto
Allan Blair Cancer Centre, Regina
Saskatoon Cancer Centre, Saskatoon
National Cancer Institute (NCI)
NIH