456
Participants
Start Date
January 10, 2022
Primary Completion Date
January 8, 2025
Study Completion Date
May 8, 2025
Nemvaleukin and Pembrolizumab Combination
Nemvaleukin: 6 µg/kg/day; Days 1 through 5 of 21-day cycles; IV infusion over 30 minutes and Pembrolizumab: 200 mg; Day 1 of 21-day cycles; IV infusion over 30 minutes
Pembrolizumab
Pembrolizumab: 200 mg; Day 1 of 21-day cycles; IV infusion over 30 minutes
Nemvaleukin
Nemvaleukin: 6 µg/kg/day; Days 1 through 5 of 21-day cycles; IV infusion over 30 minutes
Pegylated Liposomal Doxorubicin (PLD)
40 mg/m2; Day 1 of 28-day cycles; IV infusion; 1 mg/min (Cycle 1); 60 min infusion (Cycles 2+)
Paclitaxel
80 mg/m2; Days 1, 8, 15, and 22 of 28-day cycles; IV infusion over 60 min
Topotecan
4 mg/m2; Days 1, 8, and 15 of 28-day cycles; or 1.25 mg/m2, Days 1 through 5 of 21-day cycles; IV infusion over 30 min
Gemcitabine
1,000 mg/m2; Days 1 and 8 of 21-day cycles; IV infusion over 30 min
Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore, Rome
Changhua Christian Hospital (CCH), Chang-hua
Linkou Chang Gung Memorial Hospital (CGMHLK), Tainan City
National Cheng Kung University Hospital, Tainan City
Chu Saint-Pierre, Brussels
Medizinische Universitaet Wien, Vienna
Wiener Gesundheitsverbund - Klinik Hietzing, Vienna
Cliniques Universitaires Saint-Luc, Brussels
Blacktown Hospital, Blacktown
Wollongong Hospital (Illawarra Shoalhaven Local Health District), Wollongong
Canberra Hospital, Garran
AZ Klina, Brasschaat
Epworth HealthCare, East Melbourne
Clinique CHC MontLégia, Liège
Royal Brisbane and Women's Hospital, Brisbane
Icon Cancer Centre, South Brisbane
Cancer Research SA, Adelaide
Asan Medical Center, University of Ulsan, Seoul
Medizinische Universitaet Innsbruck, Innsbruck
Gangnam Severance Hospital, Yonsei University Health System, Seoul
Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul
LKH Feldkirch, Feldkirch
Medizinische Universitaet Graz, Graz
AZ Damiaan, Ostend
AZ Delta, Roeselare
Institut Catala d'Oncologia - L'Hospitalet, Barcelona
National Taiwan University Hospital, Taipei
NYU Langone Health, New York
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York
A.O. Ordine Mauriziano di Torino, Torino
National Cancer Center, Goyang-si
Taipei Veterans General Hospital, Taipei
Womens Cancer Care Associates, Albany
Vseobecna fakultni nemocnice v Praze, Prague
Institut Paoli-Calmettes, Marseille
Charite Universitaetsmedizin Berlin, Berlin
Nuovo Ospedale degli Infermi, Ponderano
Institut Catala de Oncologia - Girona, Girona
University of Pennsylvania, Philadelphia
Virginia Cancer Specialists, PC (Lake Manassas Dr), Gainesville
University of Maryland School of Medicine, Baltimore
University of Virginia - Emily Couric Cancer Center, Charlottesville
Universitaetsklinikum Schleswig-Holstein Campus Kiel, Kiel
Vidant Medical Center, Greenville
Hospital Universitario Ramon y Cajal, Madrid
Hospital Clinico San Carlos, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario La Paz, Madrid
Centro Integral Oncologico Clara Campal, Madrid
Hospital Clinico Universitario Virgen de la Arrixaca, Murcia
Emory University, Atlanta
Azienda ULSS 2 Marca trevigiana-Ospedale Ca Foncello Treviso, Treviso
University of Florida (UF) Health Cancer Center - Orlando Health, Orlando
Centro Riferimento Oncologico - Aviano, Aviano
Sarasota Memorial Hospital, Sarasota
Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria
University of Alabama at Birmingham, Birmingham
Hospital Alvaro Cunqueiro, Vigo
Taichung Veterans General Hospital, Taichung
Keimyung University Dongsan Hospital, Daegu
The Ohio State University (OSU), Columbus
Mid Ohio Oncology/Hematology, Inc. dba The Mark H. Zangmeister Center, Columbus
Institut de Cancerologie de l'Ouest - site St-Herblain, Saint-Herblain
University of Cincinnati (UC) - Cancer Institute, Cincinnati
Hospital Clinico Universitario de Valencia, Valencia
Indiana University (IU), Indianapolis
Trinity Health Ann Arbor Hospital, Ypsilanti
Barbara Ann Karmanos Cancer Institute, Detroit
Institut de Cancerologie de l'Ouest - site Angers, Angers
Universitaetsklinikum Bonn, Bonn
Avera Cancer Institute, Sioux Falls
Azienda USL Toscana Centro-Ospedale di Prato Santo Stefano, Prato
Northwestern University, Chicago
Rush University Medical Center, Chicago
Helios Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden
Masarykuv onkologicky ustav, Brno
Universitaetsklinikum des Saarlandes, Homburg
Institut de cancerologie Strasbourg Europe (ICANS), Strasbourg
Centre Leon Berard, Lyon
Universitaetsklinikum Heidelberg, Heidelberg
Mary Bird Perkins Cancer Center, Baton Rouge
Groupe Hospitalier Diaconesses Croix Saint Simon, Paris
Texas Oncology - DFWW (Bedford), Bedford
Texas Oncology - Fort Worth Cancer Center, Fort Worth
Baylor College of Medicine, Houston
Texas Oncology - Austin Central (Balcones Dr.), Austin
Arizona Oncology, Tucson
University of New Mexico, Albuquerque
University of California, Los Angeles (UCLA), Los Angeles
University of California, San Diego (UCSD)- Moores Cancer Center, La Jolla
Ventura County Hematology- Oncology, Oxnard
Gustave Roussy, Villejuif
Providence Portland Medical Center, Portland
Williamette Valley Cancer Institute and Research Center, Eugene
Alaska Women's Cancer Care, Anchorage
Westchester Medical Center, Hawthorne
National University Cancer Institute, Singapore
Astera Cancer Care, East Brunswick
Rutgers Cancer Institute of New Jersey, New Brunswick
Tom Baker Cancer Centre, Calgary
Juravinski Cancer Centre, Hamilton
London Health Sciences Centre, London
Sunnybrook Health Sciences Centre, Toronto
Princess Margaret Hospital, Toronto
Centre Hospitalier Universite de Sherbrooke (CHUS), Sherbrooke
Fakultni nemocnice Bulovka, Prague
"KEM , Evang. Kliniken Essen-Mitte gGmbH"
Universitaetsmedizin Mannheim, Mannheim
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Samsung Medical Center, Seoul
Hospital Clinic Barcelona, Barcelona
Cambridge University - Addenbrooke's Hospital, Cambridge
University College London Hospital, London
Guy's and St Thomas' NHS Foundation Trust, London
The Christie NHS Foundation Trust, Manchester
Oxford University Hospitals NHS Foundation Trust, Oxford
Lead Sponsor
Merck Sharp & Dohme LLC
INDUSTRY
Mural Oncology, Inc
INDUSTRY