Patient-Titrated Automated Intermittent Boluses of Local Anesthetic vs. a Continuous Infusion Via a Perineural Catheter for Postoperative Analgesia

PHASE4Enrolling by invitationINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

February 14, 2022

Primary Completion Date

November 30, 2026

Study Completion Date

December 31, 2026

Conditions
Pain, Acute PostoperativeTrauma Injury
Interventions
DRUG

Continuous Infusion of ropivacaine 0.2%

Patients will receive a continuous infusion of Ropivacaine 0.2% (6 mL/hr popliteal-sciatic and 8 mL/hr infraclavicular, 4 mL patient controlled bolus with 30-minute lockout) will be initiated in the recovery room.

DRUG

Titratable Automated Intermittent Boluses of ropivacaine 0.2%

"Patients will receive patient-titratable intermittent boluses of Ropivacaine 0.2% (8 mL popliteal-sciatic or 11 mL infraclavicular automated bolus every 120 minutes, 4 mL patient controlled bolus with 30-minute lockout). In addition, the infusion pump will be set in a pause mode that delays initiation of the automated bolus doses by 5 hours (this can be over-ridden by patients if they would like to initiate their perineural infusion earlier than 5 hours). Lastly, subjects will be able to titrate the volume of their automated bolus up or down within the range of 1-16 mL."

Trial Locations (1)

92103

UCSD Medical Center, San Diego

All Listed Sponsors
lead

University of California, San Diego

OTHER