A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia

PHASE1RecruitingINTERVENTIONAL
Enrollment

137

Participants

Timeline

Start Date

March 7, 2022

Primary Completion Date

May 31, 2028

Study Completion Date

February 28, 2030

Conditions
Chronic Lymphocytic Leukemia
Interventions
DRUG

Mosunetuzumab

Participants will receive subcutaneous (SC) mosunetuzumab

DRUG

Tocilizumab

Participants will receive intravenous (IV) tocilizumab as needed for cytokine release syndrome (CRS) events.

DRUG

Venetoclax

Participants will receive daily oral venetoclax

Trial Locations (30)

3002

COMPLETED

Peter MacCallum Cancer Center, East Melbourne

3168

RECRUITING

Monash Medical Centre, Melbourne

4102

RECRUITING

Princess Alexandra Hospital Woolloongabba, Woolloongabba

10065

WITHDRAWN

Memorial Sloan-Kettering Cancer Center, New York

20132

RECRUITING

Osp. San Raffaele, Milan

20162

COMPLETED

Asst Grande Ospedale Metropolitano Niguarda, Milan

25123

RECRUITING

A.O. Spedali Civili Di Brescia-P.O. Spedali Civili, Brescia

31059

WITHDRAWN

IUCT Oncopole, Toulouse

43210

RECRUITING

The James Cancer Hospital and Solove Research Institute, Columbus

50937

WITHDRAWN

Uniklinik Koln, Cologne

55902

RECRUITING

Mayo Clinic Rochester, Rochester

63003

WITHDRAWN

Chu de Clermont Ferrand, Clermont-Ferrand

77030

WITHDRAWN

Uni of Texas - Md Anderson Cancer Center, Houston

84112

RECRUITING

Huntsman Cancer Institute at The University of Utah, Salt Lake City

86156

RECRUITING

Universitätsklinikum Augsburg, Augsburg

89081

RECRUITING

Universitätsklinikum Ulm, Ulm

301600

RECRUITING

Tianjin Institute of Hematology & Blood Diseases Hospital, Tianjin

510515

RECRUITING

Southern Medical University Nanfang Hospital, Guangzhou

Unknown

RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

06132

RECRUITING

Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia, Sant'Andrea Delle Fratte (PG)

80-214

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gda?sk

30-727

RECRUITING

PRATIA MCM Kraków, Krakow

50-367

RECRUITING

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu, Wroc?aw

03080

RECRUITING

Seoul National University Hospital, Seoul

06591

RECRUITING

Seoul St Mary's Hospital, Seoul

07345

RECRUITING

Yeouido St. Mary's Hospital, Seoul

08025

RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

08035

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

M20 4BX

RECRUITING

Christie Hospital NHS Trust, Manchester

OX3 7LE

RECRUITING

Churchill Hospital, Oxford

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY