MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

October 27, 2021

Primary Completion Date

February 13, 2025

Study Completion Date

February 19, 2026

Conditions
Multiple Myeloma
Interventions
DRUG

Elranatamab + Nirogacestat

BCMA-CD3 bispecific antibody + gamma secretase inhibitor

DRUG

Elranatamab + lenalidomide + dexamethasone

BCMA-CD3 bispecific antibody + immunomodulatory

Trial Locations (33)

21205

The Johns Hopkins University School of Medicine, Baltimore

21231

OIDS, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (Also Imaging Facility), Baltimore

33136

Sylvester Comprehensive Cancer Center, Miami

UHealth Tower, Miami

33146

Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center, Coral Gables

University of Miami, Coral Gables

33442

Sylvester Comprehensive Cancer Center- Deerfield Beach, Deerfield Beach

60422

UChicago Medicine at Ingalls - Flossmoor, Flossmoor

60426

UChicago Medicine Ingalls Memorial, Harvey

60451

University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox

60462

The University of Chicago Medicine Center for Advanced Care Orland Park, Orland Park

60477

UChicago Medicine at Ingalls - Tinley Park, Tinley Park

60611

UChicago Medicine - River East, Chicago

60637

University of Chicago Medical Center, Chicago

72205

University of Arkansas for Medical Sciences - Winthrop P. Rockefeller Cancer Institute, Little Rock

85012

Banner Health d.b.a. Banner MD Anderson Cancer Center, Phoenix

85234

Banner Gateway Medical Center, Gilbert

Banner Gateway Medical Pavilion, Gilbert

Banner MD Anderson Cancer Center, Gilbert

90020

Clinical Research Advisors, Los Angeles

90048

Cedars Sinai Medical Center Oncology IDS Pharmacy Attn:Suwicha Limvorasak ,PharmaD, Los Angeles

Cedars Sinai Medical Center, Los Angeles

Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute (SOCCI), Los Angeles

Clinical Research Advisors, Los Angeles

90211

Beverly Hills Cancer Center, Beverly Hills

91316

Clinical Research Advisors, Encino

91356

Cedars-Sinai Tarzana, Tarzana

02114

Massachusetts General Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

T2N 5G2

Arthur J.E. Child Comprehensive Cancer Centre, Calgary

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

M5G 2M9

Princess Margaret Cancer Centre, Toronto

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT05090566 - MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma | Biotech Hunter | Biotech Hunter