A Randomised Open-label Phase III Trial of REduced Frequency Pembrolizumab immuNothErapy for First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC)

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,750

Participants

Timeline

Start Date

June 23, 2022

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Lung Cancer, Nonsmall Cell
Interventions
DRUG

Pembrolizumab 25 MG/ML [Keytruda]

Pembrolizumab to be given at 400mg intravenous over 5 different frequencies

Trial Locations (37)

Unknown

RECRUITING

Royal Bournemouth Hospital, Bournemouth

RECRUITING

Royal Sussex County Hospital, Brighton

RECRUITING

Bristol Haematology and Oncology Centre, Bristol

RECRUITING

Queen's Hospital, Burton-on-Trent

NOT_YET_RECRUITING

Cambridge University Hospitals NHS Foundation Trust, Cambridge

RECRUITING

East Kent Hospitals University NHS Foundation Trust, Canterbury

RECRUITING

Velindre Cancer Centre, Cardiff

RECRUITING

Colchester Hospital, Colchester

RECRUITING

Royal Derby Hospital, Derby

RECRUITING

NHS Lothian, Edinburgh

RECRUITING

Royal Devon and Exeter Hospital, Exeter

RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

RECRUITING

New Victoria Hospital, Glasgow

NOT_YET_RECRUITING

Royal Surrey NHS Foundation Trust, Guildford

RECRUITING

Calderdale & Huddersfield NHS Foundation Trust, Huddersfield

RECRUITING

Ipswich Hospital, Ipswich

RECRUITING

Kettering General Hospital, Kettering

NOT_YET_RECRUITING

NHS Fife, Kirkcaldy

RECRUITING

Forth Valley Royal Hospital, Larbert

RECRUITING

Leeds Teaching Hospitals NHS Trust, Leeds

RECRUITING

Leicester Royal Infirmary, Leicester

RECRUITING

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

RECRUITING

Guys Hospital, London

RECRUITING

Imperial College Healthcare NHS Trust, London

RECRUITING

North Middlesex University Hospital NHS Trust, London

NOT_YET_RECRUITING

St Bartholomew's Hospital, London

RECRUITING

Northampton General Hospital NHS Trust, Northampton

RECRUITING

Nottingham University Hospitals NHS Trust, Nottingham

RECRUITING

Peterborough City Hospital, Peterborough

RECRUITING

Poole Hospital, Poole

RECRUITING

Queen's Hospital, Barking Havering and Redbridge University Hospitals NHS Trust, Romford

RECRUITING

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield

RECRUITING

Royal Cornwall Hospital, Truro

RECRUITING

Worthing Hospital, Worthing

RECRUITING

Yeovil Hospital, Yeovil

M20 4BX

RECRUITING

The Christie NHS Foundation Trust, Manchester

SM2 5PT

RECRUITING

The Royal Marsden NHS Foundation Trust, Sutton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

collaborator

Medical Research Council

OTHER_GOV

collaborator

University College, London

OTHER

lead

Imperial College London

OTHER