A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

587

Participants

Timeline

Start Date

October 14, 2021

Primary Completion Date

December 8, 2028

Study Completion Date

December 8, 2028

Conditions
Multiple Myeloma
Interventions
DRUG

Daratumumab

Daratumumab will be administered SC injection.

DRUG

Pomalidomide

Pomalidomide will be administered orally.

DRUG

Dexamethasone

Dexamethasone will be administered orally or intravenously.

DRUG

Bortezomib

Bortezomib will be administered SC injection.

DRUG

Teclistamab

Teclistamab will be administered SC injection.

Trial Locations (174)

333

Chang Gung Memorial Hospital, Taoyuan District

704

National Cheng Kung University Hospital, Tainan City

2030

ZAS Cadix, Antwerp

2100

Rigshospitalet, Copenhagen

3000

UZ Leuven, Leuven

5000

Odense Universitets Hospital, Odense

7100

Hopital de Jolimont, Haine Saint Paul La Louviere

7120

Hosp. Univ. Son Espases, Palma

8000

AZ St.-Jan Brugge-Oostende AV, Bruges

8035

Hosp Univ Vall D Hebron, Barcelona

8500

Az Groeninge, Kortrijk

8800

Algemeen Ziekenhuis Delta, Roeselare

9000

UZ Gent, Ghent

10126

A.O.U. Citta della Salute e della Scienza di Torino - Presidio Molinette, Turin

15224

West Penn Hospital, Pittsburgh

15232

University of Pittsburgh Medical Center, Pittsburgh

15706

Hosp. Clinico Univ. de Santiago, Santiago de Compostela

20246

Universitaetsklinikum Hamburg Eppendorf, Hamburg

21565

Gachon University Gil Medical Center, Incheon

24105

Universitaetsklinikum Schleswig Holstein Campus Kiel, Kiel

24127

ASST Papa Giovanni XXIII Bergamo, Bergamo

25187

Helsingborgs lasarett, Helsingborg

27100

IRCCS Policlinico San Matteo, Università degli studi di Pavi, Pavia

28007

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28034

Hosp. Univ. Ramon Y Cajal, Madrid

28041

Hosp. Univ. 12 de Octubre, Madrid

28223

Hosp. Quiron Madrid Pozuelo, Pozuelo de Alarcón

30322

Emory University Winship Cancer Institute, Atlanta

31008

Clinica Univ. de Navarra, Pamplona

31059

Pôle IUC Oncopole CHU, Toulouse

33394

Hosp. de Cabuenes, Gijón

34214

Medipol University Hospital, Istanbul

35010

Hosp. Univ. de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria

35294

University of Alabama Birmingham, Birmingham

35340

Dokuz Eylul University Medical Faculty, Izmir

37007

Hosp Clinico Univ de Salamanca, Salamanca

37044

CHRU Hôpital Bretonneau, Tours

37232

Vanderbilt Ingram Cancer Center, Nashville

38120

Baptist Cancer Center, Memphis

39008

Hosp. Univ. Marques de Valdecilla, Santander

40138

Policlinico Sant'Orsola Malpighi, Bologna

40225

Heinrich-Heine -Universitaet Duesseldorf, Düsseldorf

40447

China Medical University Hospital, Taichung

41013

Hosp. Virgen Del Rocio, Seville

41944

Kyungpook National University Hospital, Daegu

44093

C.H.U. Hotel Dieu - France, Nantes

44195

Cleveland Clinic, Cleveland

45239

Evang. Krankenhaus Essen-Mitte gGmbH, Essen

46026

Hosp. Univ. I Politecni La Fe, Valencia

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

48075

Henry Ford Health System, Southfield

48202

Henry Ford Hospital, Detroit

50134

Azienda Ospedaliera Universitaria Careggi, Florence

53792

University of Wisconsin Carbone Cancer Center, Madison

55280

Ondokuz Mayis University, Atakum

57010

G.Papanikolaou, Thessaloniki

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

59037

CHRU de Lille Hopital Claude Huriez, Lille

59073

St. Barbara-Klinik Hamm GmbH, Hamm

67200

Institut de Cancerologie Strasbourg Europe ICANS, Strasbourg

69120

Universitaetsklinikum Heidelberg, Heidelberg

69495

Centre hospitalier Lyon-Sud, Pierre-Bénite

70124

U.O. Ematologia con Trapianto- AOU Policlinico di Bari, Bari

72076

Universitaetsklinikum Tuebingen, Tübingen

75185

Akademiska Sjukhuset, Uppsala

75235

University of Texas Southwestern Medical Center, Dallas

79106

Universitatsklinikum Freiburg, Freiburg im Breisgau

84112

Huntsman Cancer Institute, Salt Lake City

86021

CHU De Poitiers, Poitiers

87042

CHU de Limoges Hopital Dupuytren, Limoges

91010

City of Hope, Duarte

94000

CHU Henri Mondor, Créteil

98109

Fred Hutchinson Cancer Center, Seattle

100020

Beijing Chaoyang Hospital, Chaoyang District

100034

Peking University First Hospital, Beijing

100044

Peking University People s Hospital, Beijing

100191

Peking University Third Hospital, Beijing

110136

Shengjing Hospital Of China Medical University, Shenyang

125284

S.P. Botkin Moscow City Clinical Hospital, Moscow

130021

The First Hospital of Jilin University, Changchun

191024

Clinical Research Institute of Hematology and Transfusiology, Saint Petersburg

200032

Shanghai Zhongshan Hospital, Shanghai

210009

Zhongda Hospital Southeast University, Nanjing

221000

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

300011

Tianjin Medical University General Hospital, Tianjin

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310003

First affiliated Hospital of Zhejiang University, Hangzhou

350001

Fujian Meidical University Union Hospital, Fuzhou

410013

The Third Xiangya Hospital of Central Sourth University, Changshashi

450008

Henan Cancer Hospital, Zhengzhou

511363

Sun Yat -Sen University Cancer Center, Guangzhou

518036

Peking University Shenzhen Hospital, Shenzhen

530021

First Affiliated Hospital of Guangxi Medical University, Nanning

610041

West China Hospital Sichuan University, Chengdu

710004

The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an

4501000

Instituto D Or de Pesquisa e Ensino IDOR, São Paulo

94305-5623

Stanford University Medical Center, Stanford

06510

Yale University, New Haven

02111

Tufts Medical Center, Boston

29425-8900

Medical University of South Carolina, Charleston

C1118AAT

Hospital Aleman, Buenos Aires

C1199ABB

Hospital Italiano de Buenos Aires, Buenos Aires

X5016KEH

Hospital Privado Centro Medico de Cordoba, Córdoba

70390-140

Hospitais Integradaos da Gavea S/A - DF Star, Brasília

81520 060

Liga Paranaense de Combate ao Cancer, Curitiba

88034-000

Centro de Pesquisa e Ensino em Oncologia de Santa Catarina CEPEN, Florianópolis

59062 000

Liga Norte Riograndense Contra O Cancer, Natal

90050-170

Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre

22775 001

Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro

41253-190

Hospital Sao Rafael, Salvador

01323 900

Real e Benemerita Associacao Portuguesa de Beneficencia, São Paulo

01323-000

Hospital Paulistano, São Paulo

01455 010

Clinica Medica Sao Germano S/S LTDA, São Paulo

T2N 5G2

Arthur J E Child Comprehensive Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

V5Z 4E6

BC Cancer Agency - Vancouver BC, Vancouver

B3H 2Y9

QEII Health Sciences, Halifax

M5G 1X6

Princess Margaret Cancer Centre University Health Network, Toronto

DK-9000

Aalborg University Hospital, Aalborg

DK-8200

Aarhus University Hospital, Aarhus N

DK-7100

Vejle Hospital, Vejle

01307

Universitätsklinikum Carl-Gustav-Carus Dresden, Dresden

04103

Universitaetsklinikum Leipzig, Leipzig

115 28

Alexandra General Hospital of Athens, Athens Attica

546 39

Anticancer Hospital of Thessaloniki Theageneio, Thessaloniki

00161

Università di Roma 'La Sapienza' - Ospedale Umberto 1°, Roma

814-0180

Fukuoka University Hospital, Fukuoka

503-8502

Ogaki Municipal Hospital, Gifu

311-3193

National Hospital Organization Mito Medical Center, Higashiibaraki-gun

259-1193

Tokai University Hospital, Isehara

247-8533

Shonan Kamakura General Hospital, Kamakura-shi

277 8577

National Cancer Center Hospital East, Kashiwa

343-8555

Dokkyo Medical University Saitama Medical Center, Koshigaya

860-8556

Kumamoto University Hospital, Kumamoto

830-0011

Kurume University Hospital, Kurume

399-8701

National Hospital Organization Matsumoto Medical Center, Matsumoto

467 8602

Nagoya City University Hospital, Nagoya

663 8501

Hyogo Medical University Hospital, Nishinomiya Shi

701-1192

National Hospital Organization Okayama Medical Center, Okayama

739-0696

National Hospital Organization Hiroshima-Nishi Medical Center, Ōtake

060-8648

Hokkaido University Hospital, Sapporo

980 8574

Tohoku University Hospital, Sendai

983-8520

National Hospital Organization Sendai Medical Center, Sendai

150-8935

Japanese Red Cross Medical Center, Shibuya-ku

028-3695

Iwate Medical University Hospital, Shiwa-gun

1081 HV

VU Medisch Centrum, Amsterdam

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

3435 CM

Sint Antonius Ziekenhuis - Afd.Interne - INT, Nieuwegein

6525GA

Radboudumc, Nijmegen

8025 AB

Isala Kliniek, Zwolle

80-214

Klinika Hematologii i Transplantologii, UCK, Gdansk

40 519

Pratia Onkologia Katowice, Katowice

25 734

Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Kielce

20 090

Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli, Lublin

02-781

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warsaw

58 309

Specjalistyczny Szpital im dra Alfreda Sokolowskiego w Walbrzychu, Wałbrzych

50 367

Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu, Wroclaw

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea Seoul St Marys Hospital, Seoul

08908

Inst. Cat. Doncologia-H Duran I Reynals, Barcelona

791 82

Falu Lasarett, Falun

413 45

Sahlgrenska University Hospital, Gothenburg

971 80

Sunderby Sjukhus, Luleå

221 85

Skanes universitetssjukhus, Lund

901 85

Norrlands Universitetssjukhus, Umeå

06590

Ankara University Medical Faculty, Ankara

FY3 8NR

Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool

DD1 9SY

Ninewells Hospital & Medical School, Dundee

SE5 9RS

Kings College Hospital, London

OX3 7LE

Oxford University Hospitals NHS Foundation Trust, Oxford

PL6 8DH

University Hospitals Plymouth NHS Trust, Plymouth

SM2 5PT

Royal Marsden Hospital, Sutton

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY