Study of Magrolimab Versus Placebo in Combination With Venetoclax and Azacitidine in Participants With Acute Myeloid Leukemia

PHASE3TerminatedINTERVENTIONAL
Enrollment

378

Participants

Timeline

Start Date

July 7, 2022

Primary Completion Date

April 11, 2024

Study Completion Date

April 11, 2024

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Magrolimab

Administered intravenously (IV)

DRUG

Venetoclax

Tablets administered orally

DRUG

Azacitidine

Administered according to region-specific drug labeling, either subcutaneously (SC) or intravenously (IV)

DRUG

Placebo

Administered intravenously (IV)

Trial Locations (164)

404

China Medical University Hospital, Taichung

1083

Semmelweis Egyetem Belgyogyaszati es Hematologiai Klinika, Budapest

1130

Wiener Gesundheitsverbund, Klinik Hietzing, Vienna

1140

Hanusch Krankenhaus, Vienna

1200

Cliniques Universitaires Saint-Luc, Brussels

2060

Ziekenhuis Netwerk Antwerp (ZNA) - Stuivenberg, Antwerp

2139

Concord Repatriation General Hospital, Concord

2170

Liverpool Hospital, Liverpool

2217

St George Hospital, Clinical Research Unit Haemotology, Division of Cancer Services, Sydney

2606

Canberra Hospital, Woden

2640

Border Medical Oncology Research Unit, Albury

3000

Peter MacCallum Cancer Centre, Melbourne

University Hospital Leuven (UZ Leuven) - Campus Gasthuisberg, Leuven

3010

Inselspital Universitätsspital Bern, Bern

3076

Northern Health, Epping

3128

Monash University, Eastern Health-Box Hill Hospital, Box Hill

4000

Centre Hospitalier Universitaire de Liege, Liège

4032

Debreceni Egyetem Klinikai Központ Belgyogyaszati Klinika B epulet Hematologia, Hajdu-bihar

4215

Gold Coast University Hospital, Southport

6591

The Catholic University of Korea Seoul Saint Mary's Hospital, Seoul

6725

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Kozpont, Szeged

7100

Hopital de Jolimont, Haine-Saint-Paul

9000

University Hospital Gent, Ghent

9024

Petz Aladár Egyetemi Oktató Kórház II. Belgyógyaszat - Haematológia, Győr

10002

National Taiwan University Hospital, Taipei

10021

New York-Presbyterian/Weill Cornell Medical Center, New York

10029

Icahn School of Medicine at Mount Sinai and The Mount Sinai Hospital, New York

11490

National Cheng Kung University Hospital, Taipei

13353

Charite - Universitatsmedizin Berlin, Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt Hamatologie, Onkologie und Tumorimmunologie, Berlin

14004

Hospital Universitario Reina Sofia, Córdoba

14642

University of Rochester Medical Center, Rochester

15224

West Penn Hospital, Pittsburgh

15706

Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela

17033

Penn State Hershey Medical Center, Hershey

19111

Fox Chase Cancer Center, Philadelphia

20052

ASST Monza-Ospedale San Gerardo, Monza

20089

IRCCS Istituto Clinico Humanitas, Milan

20090

Centrum Onkologii Ziemi Lubelskiej im. Sw. Jana z Dukli, Oddzial Hematologiczny, Lublin

20099

Asklepios Klink St.Georg, Hamburg

21201

University of Maryland, Greenebaum Comprehensive Cancer Center, Baltimore

24127

ASST Papa Giovanni XXIII, Bergamo

24939

Malteser Krankenhaus St. Franziskus Hospital,Med.Klinik I, Flensburg

26133

Klinikum Oldenburg, Rahel-Straus-Straße 10, Oldenburg

27103

Novant Health Cancer Institute Hematology - Forsyth, Winston-Salem

Wake Forest Baptist Health, Winston-Salem

27514

UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill

28009

Hospital General Universitario Gregorio Maranon, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

Hospital Universitario La Paz, Madrid

28204

Novant Health Cancer Institute Hematology- Charlotte, Charlotte

29010

Hospital Regional Universitario de Malaga, Málaga

30625

Medizinische Hochschule Hannover, Hamatologie, Hamostaseologie, Onkologie und Stammzelltrandsplantation, Hanover

31059

Institut Universitaire du Cancer de Toulouse (IUCT)-Oncopole, Toulouse

31096

Rambam Health Care Campus, Haifa

32207

Baptist MD Anderson Cancer Center, Jacksonville

32429

Johannes Wesling Klinikum Minden Universitätsklinik fur Hämatologie, Onkologie, Hämostaseologie und Pastativrndezin, Universitatsklinik der Ruhr-Unive, Minden

33612

Moffitt Cancer Center, Tampa

37007

Complejo Asistencial Universitario de Salamanca - Hospital Clinico, Salamanca

38114

Städtisches Klinikum Braunschweig GmbH Medizinische Klinik III/Hämatologie und Onkologie, Braunschweig

38700

Centre Hospitalier Universitaire Grenoble Alpes, La Tronche

39120

Universitätsklinikum Magdeburg, Magdeburg

40138

Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola-Malpighi, Bologna

40225

Universitatsklinikum Dusseldorf, Klink fur Hamatologie, Onkologie und Klinische Immunologie, Düsseldorf

40479

Marien Hospital Dusseldorf GmbH, Klinik Fur Onkologie, Hamatologie Und Palliativmedizin, Düsseldorf

44093

Centre Hospitalier Universitaire Nantes - Hotel Dieu, Nantes

44106

University Hospitals Cleveland Medical Center, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

46026

Hospital Universitari I Politecnic La Fe, Valencia

46237

Indiana Blood and Marrow Transplantation - Clinic, Indianapolis

46845

Parkview Research Center, Fort Wayne

49033

CHU d'Angers, Angers

49100

Rabin Medical Center, Petah Tikva

52242

The University of Iowa Hospitals and Clinics, Iowa City

52621

The Chaim Sheba Medical Center, Ramat Gan

53127

Universitätsklinikum Bonn, Bonn

53226

Froedtert Hospital and the Medical College of Wisconsin, Milwaukee

54500

CHU de Nancy - Hopitaux de Brabois, Vandœuvre-lès-Nancy

59037

Hôpital Claude Huriez (CHRU de Lillle), Lille

60153

Loyola University Medical Center, Maywood

60590

Universitatsklinikum Frankfurt Goethe Universitat Med. Klink II, Frankfurt

61122

"Azienda Sanitaria Territoriale Pesaro e Urbino - Stabilimento Ospedaliero San Salvatore - Muraglia - U.O. Ematologia e Centro Trapianti", Pesaro

62002

Masstricht Universitair Medisch Centrum, Maastricht

63110

SSM Health Saint Louis University Hospital, St Louis

64132

MidAmerica Division, Inc., c/o Research Medical Center, Kansas City

67033

Institut de Cancérologie Strasbourg Europe (ICANS), Strasbourg

69373

Centre Leon Berard, Lyon

69495

Centre Hospitalier Lyon-Sud (CHLS), Pierre-Bénite

70852

Fakultni nemocnice Ostrava, Klinika hematoonkologie, Ostrava

72205

University of Arkansas for Medical Sciences, Little Rock

73104

OU Health Stephenson Cancer Center, Oklahoma City

75010

Hopital Saint-Louis, Paris

75246

Baylor University Medical Center, Dallas

77030

Houston Methodist Hospital Cancer Center, Houston

MD Anderson Cancer Center, Houston

77520

Fakultni nemocine Olomouc, Hemato-onkologicka klinika, Olomouc

78157

Centre Hospitalier de Versailles, Le Chesnay

78234

Brooke Army Medical Center, Fort Sam Houston

80054

CHU Amiens Picardie, Amiens

81675

Klinikum rechts der Isar Technischen Universitat Munchen, München

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

84143

Intermountain Health - LDS Hospital, Salt Lake City

89070

Universitatsklinikum Ulm, Zentrum fur Innere Medizin, Klinik fur Innere Medizin III, Ulm

91010

City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte

91120

Hadassah University Hospital Ein Kerem, Jerusalem

92868

UC Irvine Health- Chao Family Comprehensive Cancer Center, Orange

93000

Hopital Avicenne, Bobigny

93053

Universitatsklinikum Regensburg, Klink fur Innere Medizin III, Regensburg

93730

Community Cancer Institute, Fresno

94010

Hopitaux Universitaires Henri Mondor, Créteil

97213

Providence Cancer Institute Franz Clinic, Portland

98101

Virginia Mason Franciscan Health, Seattle

98109

Fred Hutchinson Cancer Center, Seattle

9103102

Shaare Zedek Medical Center, Jerusalem

01655

University of Massachusetts Worcester, Worcester

07601

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

08901

Rutgers Cancer Institute of New Jersey, New Brunswick

02903

Rhode Island Hospital, Providence

Unknown

Ordensklinikum Linz GmbH Elisabethinen, Linz

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong

Princess Margaret Hospital, Hong Kong

Queen Mary Hospital, Hong Kong

Tuen Mun Hospital, Hong Kong

Azienda Ospedaliera di Perugia - Santa Maria della Misericordia, Perugia

Hospital Universitario Araba, Alava

Hospital Universitario Quironsalud Madrid, Madrid

Hospital Universitario Ramon y Cajal, Madrid

B3H 1V7

Queen Elizabeth II (QEII) Health Sciences Centre, Halifax

H1T 2M4

Centre Integre Universitaire de Sante et de Services Sociaux(CIUSSS) de l'Est-de-L'Ile-de- Montreal - Hopital Maisonneuve-Rosemont, Montreal

M5G 2M9

Princess Margaret Cancer Centre - University Health Network, Toronto

R3E 0V9

CancerCare Manitoba, Winnipeg

625 00

Fakultni nemocnice Brno, Interni hematologicka a onkologicka klinika FN Brno a LF MU, Jihormoravsky KRAJ

100 34

Fakulti nemocnice Kralovske Vinohrady, Internf hematologicka klinika FNKV a 3. LF UK, Prague

128 08

Vseobecna fakultni nemocnice v Praze, Fakultni poliklinika, Hematologicka ambulance, Prague

I-60126

Azienda Ospedaliero Universitaria delle Marche - SOD Clinica di Ematologia, Ancona

5223GZ

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

3813 TZ

Meander Medisch Centrum, Amersfoort

1081 HV

Amsterdam Universitair Medische Centra-Locatie Vrije Universiteit Medisch Centrum, Amsterdam

4818 CK

Amphia Hospital, department Oncologie, Route 43, Breda

7512 KZ

Medisch Spectrum Twente - Enschede Koningsplein, Enschede

9700 RB

Universitair Medisch Centrum Groningen, Groningen

8934 AD

Medisch Centrum Leeuwarden, Leeuwarden

3435 CM

St. Antonius Ziekenhuis, Nieuwegein, Nieuwegein

6532 SZ

Canisius Wilhelmina Ziekenhuis, Nijmegen

3000 CA

Erasmus Medisch Centrum, Rotterdam

2545AA

HagaZiekenhuis, The Hague

0424

Oslo University Hospital, Department of Hematology, Oslo

93-510

Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M.Kopernika w Lodzi, Oddzial Hematologii Ogolnej, Lodz

45-372

Szpital Wojewodozki w Opolu Sp. z 0.0. Oddzial Klinixzny Hematologii, Onkologii Hematologicznej i Chorob Wemnetrznych, Opole

03080

Seoul National University Hospital, Seoul

06351

Samsung Medical Center, Seoul

120-752

Severance Hospital, Seoul

138-736

Asan Medical Center, Seoul

08036

Hospital Clinic de Barcelona, Barcelona

FY3 8NR

Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool

BS2 8ED

University Hospitals Bristol and Weston NHS Foundation Trust, Bristol

LS9 7TF

Leeds Teaching Hospitals NHS Trust, Leeds

L7 8YA

Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

EC1A 7BE

Barts Health NHS Trust, London

SE5 9RS

King's College Hospital, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

NE7 7DN

Newcastle upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne

OX3 7LE

Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford

CV34 5BW

South Warwickshire University NHS Foundation Trust, Warwick

WV10 0QP

The Royal Wolverhampton NHS Trust, Wolverhampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY