Effects of Microplegia on Transfusion Rates After Cardiac Surgery

PHASE4CompletedINTERVENTIONAL
Enrollment

314

Participants

Timeline

Start Date

March 25, 2019

Primary Completion Date

June 1, 2023

Study Completion Date

August 1, 2023

Conditions
Aortic Valve DiseaseMitral Valve Disease
Interventions
DRUG

Cardioplegia Solution

"The microplegia solution that is standard of care for all cardiac surgery patients, and which all study subjects will receive is:~Induction 240 mL Baxter Cardioplegia Solution 10. 5 mL Potassium Chloride 2 meq/ml (21 meq) 250.5 mL total volume~Maintenance 747 mL Baxter Cardioplegia Solution 3.4 mL Potassium Chloride 2 meq/ml (6.75 meq) 750.4 mL total volume~Subjects will be randomly assigned to 4:1 cardioplegia or nondiluted microplegia.~4:1 cardioplegia consists of 4 parts crystalloid intravenous fluid to one part human blood.~Nondiluted microplegia consists of all parts human blood."

DRUG

Microplegic Solution No. 1

"The microplegia solution that is standard of care for all cardiac surgery patients, and which all study subjects will receive is:~Induction 240 mL Baxter Cardioplegia Solution 10. 5 mL Potassium Chloride 2 meq/ml (21 meq) 250.5 mL total volume~Maintenance 747 mL Baxter Cardioplegia Solution 3.4 mL Potassium Chloride 2 meq/ml (6.75 meq) 750.4 mL total volume~Subjects will be randomly assigned to 4:1 cardioplegia or nondiluted microplegia.~4:1 cardioplegia consists of 4 parts crystalloid intravenous fluid to one part human blood.~Nondiluted microplegia consists of all parts human blood."

Trial Locations (1)

63110

Washington University School of Medicine, St Louis

All Listed Sponsors
collaborator

Quest Medical, Inc

INDUSTRY

lead

Washington University School of Medicine

OTHER

NCT05076604 - Effects of Microplegia on Transfusion Rates After Cardiac Surgery | Biotech Hunter | Biotech Hunter