NCT05074810 - Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients | Biotech Hunter

Enrollment

153

Participants

Timeline

Start Date

April 12, 2022

Primary Completion Date

September 30, 2025

Study Completion Date

April 30, 2027

Conditions

Non Small Cell Lung CancerKRAS Activating Mutation

Interventions

DRUG

avutometinib and sotorasib

The RP2D of avutometinib + sotorasib determined in Part A will be used in Part B dose expansion

DRUG

avutometinib and sotorasib and defactinib

The RP2D of avutometinib + sotorasib + defactinib determined in Part A will be used in Part B dose expansion

Trial Locations (35)

4000

RECRUITING

CHU de Liège, Liège

9000

RECRUITING

University Hospital Gent, Ghent

15006

RECRUITING

Hospital Teresa Herrera (C.H.U.A.C), A Coruña

19008

RECRUITING

Consultants in Medical Oncology & Hematology, Broomall

19044

RECRUITING

Alliance Cancer Specialists,, Horsham

20007

RECRUITING

Georgetown University Medical Center, Washington D.C.

20010

RECRUITING

MedStar Washington Hospital Center, MedStar Georgetown Cancer Institute,, Washington D.C.

20850

RECRUITING

Maryland Oncology & Hematology, P.A., Rockville

22031

RECRUITING

Virginia Cancer Specialists, PC, Fairfax

24060

RECRUITING

Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care, Blacksburg

28007

RECRUITING

Hospital General Universitario Gregorio Marañón, Madrid

28040

RECRUITING

Hospital Universitario Fundación Jiménez Díaz, Madrid

29010

RECRUITING

Hospital Universitario Virgen De La Victoria, Málaga

41009

RECRUITING

Hospital Universitario Virgen de la Macarena, Seville

43210

RECRUITING

Ohio State University Brain and Spine Hospital, Columbus

44195

RECRUITING

Cleveland Clinic Taussig Cancer Center, Cleveland

48202

RECRUITING

Henry Ford Health System, Detroit

55125

RECRUITING

Minnesota Oncology Hematology, P.A, Woodbury

59037

RECRUITING

CHRU of Lille, Lille

60005

RECRUITING

Illinois Cancer Specialists, Arlington Heights

63110

RECRUITING

Washington University School of Medicine, St Louis

75014

RECRUITING

Hôpital Cochin, Paris

75390

RECRUITING

University of Texas Southwestern Medical Center, Dallas

75601

RECRUITING

Texas Oncology, Longview

76104

RECRUITING

Texas Oncology - Fort Worth Cancer Center, Fort Worth

78731

RECRUITING

Texas Oncology, Austin

80303

RECRUITING

Rocky Mountain Cancer Center, LLP, Boulder

92150

RECRUITING

Hôpital Foch, Suresnes

98684

RECRUITING

Northwest Cancer Specialists, Vancouver

02215

RECRUITING

Dana Farber Cancer Institute, Boston

2333 ZA

RECRUITING

Leids Universitair Medisch Centrum, Leiden

3015 GD

RECRUITING

Erasmus MC, Rotterdam

LE2 7LX

RECRUITING

University of Leicester, Leicester

SW3 6JJ

RECRUITING

Royal Marsden Hospital, London

SM2 5PT

RECRUITING

Royal Marsden Hospital, Sutton