Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis (CHRONOS-2)

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

May 31, 2022

Primary Completion Date

November 30, 2024

Study Completion Date

November 30, 2026

Conditions
Osteomyelitis - Foot
Interventions
DRUG

Reduction in the duration of antibiotic therapy 3 weeks or 6 weeks

"Drugs :~* Rifampin (IP an PO) : 10mg/Kg/12h~* Ofloxacin (PO) : 200Mg/8h~* Levofloxacin (PO) : 500mg ot 1g/ twice a day~* Ciprofloxacin : IV : 400mg/8h if Pseud spp ; 400mg/12h for others Gram-negative bacilli strains; PO : 1gr/12h if Pseud spp ; 750mg/12h for others Gram-negative bacilli strains~* Clindamycin : 600-900mg/8h~* Fusidic Acid : 500mg/8h~* Teicoplanin : 10mg/kg/12h for 5 dosis in combination, then in monotherapy.~* Ceftasidim : 2g/8h if Pseud spp ; 2g/12h for others Gram-negative bacilli strains~* Trimethoprim-sulfamethoxazole (800mg/160mg) : once per day if patient \< 80Kg ; one and a half per day if patient \> 80Kg.~* Doxycyclin : 200mg/day~* Minocyclin : 100mg/8h to 12h~* Ceftriaxon : 1g to 2g/day in IV, IM or SC~* Cefotaxim : 1g to 2g/day in IV~* Pristinamycin : 1g thrice a day"

Trial Locations (18)

59100

Centre Hospitalier de Roubaix, Roubaix

Unknown

Centre Hospitalier de Béthune-Beuvry, Béthune

AP-HP Ambroise Paré, Boulogne-Billancourt

Centre Hospitalier de Boulogne-sur-Mer, Boulogne-sur-Mer

Centre Hopitalier Universitaire de Brest, Brest

Centre Hospitalier Universitaire de Caen, Caen

Centre Hospitalier de Compiègne-Noyon, Compiègne

Centre Hospitalier de Dunkerque, Dunkirk

Centre Hospitalier de Lens, Lens

Centre Hospitalier Universitaire de Lille, Lille

GHICL Saint-Vincent de Paul, Lille

GHICL Saint-Philibert, Lomme

Centre Hospitalier Universitaire de Montpellier, Montpellier

Centre Hospitalier Universitaire de Nantes, Nantes

AP-HP Cochin, Paris

AP-HP Lariboisière, Paris

Centre Hospitalier Universitaire de Rouen, Rouen

Centre Hospitalier de Valenciennes, Valenciennes

All Listed Sponsors
lead

Tourcoing Hospital

OTHER

NCT05074147 - Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis (CHRONOS-2) | Biotech Hunter | Biotech Hunter