4,300
Participants
Start Date
July 27, 2022
Primary Completion Date
July 31, 2027
Study Completion Date
July 31, 2028
lidocaine 2% and 10%
"Lidocaine infusion:~1. Commencing with an intravenous bolus after induction of anaesthesia, 0.125 ml/kg of lean body weight (LBW) of 2% lidocaine (2.5 mg/kg).\*~2. Followed by a 2% lidocaine intravenous infusion for the duration of surgery, 0.1665 ml/kg/h of LBW (3.33 mg/kg/hr).\*~3. A post-operative subcutaneous 0.0222 ml/kg/hr of LBW 10% lidocaine infusion for up to 24 hours thereafter (2.22 mg/kg/hr). Dosage will be capped at a maximum lean body weight of 68kg.~ * \*Day-case surgery receives intraoperative bolus and intraoperative infusion only"
Placebo
"Placebo infusion:~1. Commencing with an intravenous bolus after induction of anaesthesia, 0.125 ml/kg of lean body weight (LBW) of 0.9% Saline solution.\*~2. Followed by a 0.9% Saline solution intravenous infusion for the duration of surgery, 0.1665 ml/kg/h of LBW (3.33 mg/kg/hr).\*~3. A post-operative subcutaneous 0.0222 ml/kg/hr of LBW 0.9% Saline solution infusion for up to 24 hours thereafter (2.22 mg/kg/hr). Dosage will be capped at a maximum lean body weight of 68kg.~ * \*Day-case surgery receives intraoperative bolus and intraoperative infusion only"
RECRUITING
Auckland City Hospital, Auckland
RECRUITING
Middlemore Hospital, Auckland
RECRUITING
Royal North Shore Hospital, Sydney
RECRUITING
Westmead Hospital, Sydney
RECRUITING
St George Hospital, Sydney
RECRUITING
Blacktown Mount Druitt Hospital, Mount Druitt
RECRUITING
The Alfred, Melbourne
RECRUITING
Royal Melbourne Hospital, Melbourne
RECRUITING
St Vincent's Hospital Melbourne, Melbourne
NOT_YET_RECRUITING
Northern Hospital, Melbourne
RECRUITING
Maroondah Hospital - Eastern Health, Ringwood East
COMPLETED
Monash Health - Moorabbin Hospital, Melbourne
RECRUITING
Waikato Hospital, Hamilton
RECRUITING
Barwon Health - University Hospital Geelong, Geelong
COMPLETED
Anaesthetic Group Ballarat, Ballarat
RECRUITING
Ballarat Health Services (Grampians Health), Ballarat
RECRUITING
Goulburn Valley Health, Shepparton
WITHDRAWN
Latrobe Regional Hospital, Traralgon
RECRUITING
Royal Brisbane and Women's Hospital, Brisbane
RECRUITING
Princess Alexandra Hospital, Woolloongabba
RECRUITING
Queen Elizabeth II Jubilee Hospital, Coopers Plains
COMPLETED
Gold Coast Hospital and Health Service- Gold Coast University Hospital, Southport
COMPLETED
Rockhampton Hospital, Rockhampton
RECRUITING
Mackay Base Hospital, Mackay
RECRUITING
Flinders Medical Centre, Bedford Park
RECRUITING
Royal Perth Hospital, Perth
RECRUITING
St John of God Subiaco, Perth
RECRUITING
Royal Hobart Hospital, Hobart
RECRUITING
North District Hospital, Shatin
RECRUITING
Pamela Youde Nethersole Eastern Hospital, Chai Wan
RECRUITING
Ruttonjee Hospital, Wan Chai
RECRUITING
University Hospital Wishaw, Wishaw
RECRUITING
Royal Liverpool and Broadgreen Hospitals, Liverpool
RECRUITING
Royal Marsden Hospital, London
RECRUITING
Newcastle upon Tyne Hospitals, Newcastle upon Tyne
RECRUITING
University Hospital Southampton, Southampton
RECRUITING
Southmead Hospital, North Bristol Trust, Bristol
COMPLETED
Darlington Memorial Hospital, Darlington
RECRUITING
Russells Hall Hospital, Dudley
RECRUITING
Norfolk and Norwich University Hospital, Norwich
RECRUITING
Rotherham NHS Foundation Trust, Rotherham
RECRUITING
St Helen's Hospital, St Helens
RECRUITING
Torbay Hospital, Torquay
Royal Perth Hospital
OTHER
Monash University
OTHER