Combined Flow and Pressure Study of Craniospinal Dynamic

Active, not recruitingOBSERVATIONAL
Enrollment

73

Participants

Timeline

Start Date

September 1, 2021

Primary Completion Date

September 1, 2023

Study Completion Date

September 30, 2024

Conditions
Intracranial PressureCerebral Blood FlowsInfusion TestPhase Contrast MRIHydrocephalusDementia
Interventions
OTHER

Flow MRI

"4 flow acquisitions based on the 2D cine phase contrast sequence (present on all MRI systems) will be performed.~This sequence requires a cardiac synchronization by a plethysmograph put on the patient's finger.~32 cardiac phases are reconstructed per acquisition. The processing of the flow MRIs and the analysis of the flow curves of the LCS and blood during the cardiac cycle will be performed using the Amiens software.~Parameters measured via flow MRI are:~\- Cerebral vascular flow, intracranial LCS dynamic volume, extracranial LCS dynamic volume"

OTHER

PERFUSION TEST

"The test will be performed will include:~* Inserting a needle into the lumbar space, Ommaya reservoir or valve pre-chamber, as appropriate~* Connect the needle to the pressure transducer via saline filled manometer lines connected via a 3-way valve. The other end of the 3-way connection will be connected to a saline~* Recording of the opening pressure for 10 minutes~* The infusion test is terminated either when the pressure stabilizes again on a new plateau, or when the average pressure exceeds 40 mmHg, or in case of adverse effects or symptoms such as headache, nausea/vomiting or visual disturbances.~* At the end of the test, a depletion of 30 to 50 mL of CSF will be performed.~* The pressure recording during the test is then used to calculate the parameters of the mechanical properties of the CSF circulation and reported to the neurosurgeon ordering the test."

Trial Locations (1)

80480

CHU Amiens, Salouël

All Listed Sponsors
collaborator

University Hospital, Caen

OTHER

collaborator

University Hospital, Brest

OTHER

lead

Centre Hospitalier Universitaire, Amiens

OTHER