Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

430

Participants

Timeline

Start Date

March 13, 2023

Primary Completion Date

December 15, 2027

Study Completion Date

December 15, 2027

Conditions
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Metastatic Head and Neck Squamous Cell CarcinomaMetastatic Hypopharyngeal Squamous Cell CarcinomaMetastatic Laryngeal Squamous Cell CarcinomaMetastatic Lip and Oral Cavity CarcinomaMetastatic Nasal Cavity Squamous Cell CarcinomaMetastatic Nasopharyngeal Squamous Cell CarcinomaMetastatic Pharyngeal Squamous Cell CarcinomaMetastatic Sinonasal Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell CarcinomaRecurrent Hypopharyngeal Squamous Cell CarcinomaRecurrent Laryngeal Squamous Cell CarcinomaRecurrent Lip and Oral Cavity Squamous Cell CarcinomaRecurrent Nasopharyngeal Squamous Cell CarcinomaRecurrent Pharyngeal Squamous Cell CarcinomaRecurrent Sinonasal Squamous Cell CarcinomaStage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8Stage IV Hypopharyngeal Carcinoma AJCC v8Stage IV Laryngeal Cancer AJCC v8Stage IV Lip and Oral Cavity Cancer AJCC v8Stage IV Nasopharyngeal Carcinoma AJCC v8Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8Stage IV Sinonasal Cancer AJCC v8
Interventions
BIOLOGICAL

Atezolizumab

Given IV

BIOLOGICAL

Bevacizumab

Given IV

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Carboplatin

Given IV

BIOLOGICAL

Cetuximab

Given IV

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT scan

DRUG

Docetaxel

Given IV

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET scan

Trial Locations (172)

15009

UPMC-Heritage Valley Health System Beaver, Beaver

15065

UPMC Cancer Center-Natrona Heights, Natrona Heights

15108

UPMC Hillman Cancer Center in Coraopolis, Moon Township

15122

UPMC West Mifflin-Cancer Center Jefferson, West Mifflin

15132

UPMC Cancer Center at UPMC McKeesport, McKeesport

15146

Forbes Hospital, Monroeville

UPMC Hillman Cancer Center - Monroeville, Monroeville

15212

Allegheny General Hospital, Pittsburgh

15215

UPMC-Saint Margaret, Pittsburgh

15219

UPMC-Mercy Hospital, Pittsburgh

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15243

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15301

UPMC Cancer Center-Washington, Washington

15401

UPMC Cancer Center-Uniontown, Uniontown

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

15642

Arnold Palmer Cancer Center Medical Oncology Norwin, N. Huntingdon

15666

UPMC Hillman Cancer Center - Part of Frick Hospital, Mount Pleasant

15701

IRMC Cancer Center, Indiana

15901

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown

16001

UPMC Hillman Cancer Center at Butler Health System, Butler

16066

UPMC Hillman Cancer Center - Passavant - Cranberry, Cranberry Township

16105

UPMC Hillman Cancer Center - New Castle, New Castle

16121

UPMC Cancer Center at UPMC Horizon, Farrell

16125

UPMC Hillman Cancer Center in Greenville/UPMC Horizon, Greenville

16346

UPMC Cancer Center at UPMC Northwest, Seneca

16505

UPMC Hillman Cancer Center Erie, Erie

16601

UPMC Altoona, Altoona

17011

UPMC Camp Hill, Camp Hill

17015

Carlisle Regional Cancer Center, Carlisle

17050

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

17109

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17408

UPMC Memorial, York

17754

Divine Providence Hospital, Williamsport

19090

Asplundh Cancer Pavilion, Willow Grove

19107

Thomas Jefferson University Hospital, Philadelphia

19114

Jefferson Torresdale Hospital, Philadelphia

19713

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

20010

MedStar Washington Hospital Center, Washington D.C.

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21204

Greater Baltimore Medical Center, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

21502

UPMC Western Maryland, Cumberland

25304

West Virginia University Charleston Division, Charleston

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33316

Broward Health Medical Center, Fort Lauderdale

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37772

Thompson Oncology Group-Lenoir City, Lenoir City

37830

Thompson Oncology Group-Oak Ridge, Oak Ridge

37916

Thompson Cancer Survival Center, Knoxville

37932

Thompson Cancer Survival Center - West, Knoxville

43623

Toledo Clinic Cancer Centers-Toledo, Toledo

43952

Trinity's Tony Teramana Cancer Center, Steubenville

45331

Miami Valley Cancer Care and Infusion, Greenville

45373

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Premier Blood and Cancer Center, Dayton

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Miami Valley Hospital South, Centerville

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50023

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50263

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

ProHealth D N Greenwald Center, Mukwonago

53188

UW Cancer Center at ProHealth Care, Waukesha

55101

Regions Hospital, Saint Paul

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

Mercy Hospital, Coon Rapids

57701

Rapid City Regional Hospital, Rapid City

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

60426

Ingalls Memorial Hospital, Harvey

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

University of Chicago Medicine-Orland Park, Orland Park

60504

Rush-Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

60612

John H Stroger Jr Hospital of Cook County, Chicago

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

HSHS Saint Elizabeth's Hospital, O'Fallon

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

63128

Mercy Hospital South, St Louis

63703

Saint Francis Medical Center, Cape Girardeau

70112

University Medical Center New Orleans, New Orleans

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

87106

University of New Mexico Cancer Center, Albuquerque

88011

Memorial Medical Center-Las Cruces, Las Cruces

92612

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94304

Stanford Cancer Institute Palo Alto, Palo Alto

VA Palo Alto Health Care System, Palo Alto

94568

Epic Care-Dublin, Dublin

94608

Epic Care Partners in Cancer Care, Emeryville

96701

Hawaii Cancer Care - Westridge, ‘Aiea

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

96817

Queen's Cancer Center - Kuakini, Honolulu

97015

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

94553-3156

Contra Costa Regional Medical Center, Martinez

06418

Smilow Cancer Hospital-Derby Care Center, Derby

06824

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06033

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury

06830

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

Smilow Cancer Hospital Care Center - Guilford, Guilford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06520

Yale University, New Haven

06473

Yale-New Haven Hospital North Haven Medical Center, North Haven

06477

Smilow Cancer Hospital-Orange Care Center, Orange

06902

Smilow Cancer Hospital Care Center at Long Ridge, Stamford

06790

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

Smilow Cancer Hospital Care Center - Waterford, Waterford

01655

UMass Memorial Medical Center - University Campus, Worcester

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

02891

Smilow Cancer Hospital Care Center - Westerly, Westerly

05819

Dartmouth Cancer Center - North, Saint Johnsbury

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH