Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

153

Participants

Timeline

Start Date

September 6, 2021

Primary Completion Date

July 31, 2024

Study Completion Date

July 31, 2025

Conditions
Advanced CancerLung CancerHead and Neck CancerMelanoma
Interventions
DRUG

EOS-448

Anti-TIGIT monoclonal antibody

DRUG

pembrolizumab

Anti-PD-1 monoclonal antibody

DRUG

inupadenant

A2A receptor antagonist

DRUG

Dostarlimab

Anti-PD-1 monoclonal antibody

DRUG

SOC chemotherapies

SOC chemotherapies in 1L mNSCLC

Trial Locations (42)

1200

Cliniques universitaires St Luc-UCL, Brussels

2610

GZA Ziekenhuizen campus Sint-Augustinus, Antwerp

3000

UZ Leuven, Leuven

3500

Jessa Ziekenhuis, Hasselt

7000

CHU Helora, Mons

10060

FPO-IRCCS Candiolo Cancer Insitute, Candiolo

14033

CHU Caen, Caen

20089

IDB Center-Istituto Clinico Humanitas (IRCCS), Rozzano

21079

Centre Georges Francois Leclerc, Dijon

23007

Hospital Universitario de Jaen, Jaén

27100

Universita degli Studi di Pavia - Fondazione IRCCS Policlinico San Matteo, Pavia

28040

Hospital Clinico San Carlos, Madrid

Hospital Universitario Fundación Jiménez Díaz - START Madrid, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

29004

Hospital Quirón Málaga, Málaga

31008

Hospital Universitario de Navarra, Pamplona

33075

Hôpital Saint André, Bordeaux

41009

Hospital Universitario Virgen Macarena, Seville

44805

Institut de Cancérologie de l'Ouest, Nantes

46009

Fundacion Instituto Valenciano de Oncologia (IVO), Valencia

46014

Consorci Hospital Gral Univ Valencia, Valencia

46026

Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur), Valencia

48121

AUSL Della Romagna - Ospedale S. Maria delle Croci, Ravenna

50009

Hospital Universitario Miguel Servet, Zaragoza

54519

Institut de Cancerologie Lorraine (ICL), Nancy

59000

Centre Oscar Lambret, Lille

67033

ICANS, Strasbourg

69373

Centre Léon Bérard, Lyon

72000

Clinique Victor Hugo, Le Mans

75013

Pitié Salpêtrière, Paris

86000

CHU de POITIERS, Poitiers

92037

University of California San Diego, San Diego

07601

Hackensack University Medical Center, Bergen

06189

Centre Antoine Lacassagne, Nice

08243

Hospital Althaia Xarxa Assitencial de Manresa, Manresa

06006

Hospital Universitario de Badajoz, Badajoz

08035

Vall d'Hebron, Barcelona

SM2 5PT

Royal Marsden Hospital (Sutton location), Sutton

CB2 0QQ

Addenbrooke's Hospital, Cambridge

SW3 6JJ

Royal Marsden Hospital (London location), London

W12 0HS

Hammersmith Hospital, London

NG5 1PB

Nottingham City Hospital, Nottingham

Sponsors
All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

collaborator

iTeos Therapeutics

INDUSTRY

lead

iTeos Belgium SA

INDUSTRY