Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

189

Participants

Timeline

Start Date

June 28, 2022

Primary Completion Date

October 1, 2028

Study Completion Date

October 1, 2028

Conditions
Advanced Extrapulmonary Neuroendocrine CarcinomaMetastatic Extrapulmonary Neuroendocrine CarcinomaRecurrent Extrapulmonary Neuroendocrine CarcinomaUnresectable Extrapulmonary Neuroendocrine Carcinoma
Interventions
BIOLOGICAL

Atezolizumab

Given IV

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Carboplatin

Given IV

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT scan

DRUG

Etoposide

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

OTHER

Patient Observation

Undergo observation

Trial Locations (228)

10029

ACTIVE_NOT_RECRUITING

Mount Sinai Hospital, New York

11794

ACTIVE_NOT_RECRUITING

Stony Brook University Medical Center, Stony Brook

14263

SUSPENDED

Roswell Park Cancer Institute, Buffalo

26330

SUSPENDED

United Hospital Center, Bridgeport

26506

RECRUITING

West Virginia University Healthcare, Morgantown

27518

RECRUITING

Duke Cancer Center Cary, Cary

27534

RECRUITING

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

27609

RECRUITING

Duke Cancer Center Raleigh, Raleigh

27710

RECRUITING

Duke University Medical Center, Durham

28025

RECRUITING

Atrium Health Cabarrus/LCI-Concord, Concord

28054

RECRUITING

Levine Cancer Institute-Gaston, Gastonia

28203

RECRUITING

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28211

RECRUITING

Levine Cancer Institute-SouthPark, Charlotte

28262

RECRUITING

Atrium Health University City/LCI-University, Charlotte

28277

RECRUITING

Levine Cancer Institute-Ballantyne, Charlotte

28328

RECRUITING

Southeastern Medical Oncology Center-Clinton, Clinton

28374

RECRUITING

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

28546

RECRUITING

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29425

SUSPENDED

Medical University of South Carolina, Charleston

33308

RECRUITING

Holy Cross Hospital, Fort Lauderdale

33612

SUSPENDED

Moffitt Cancer Center, Tampa

37232

SUSPENDED

Vanderbilt University/Ingram Cancer Center, Nashville

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

43623

SUSPENDED

Toledo Clinic Cancer Centers-Toledo, Toledo

46307

RECRUITING

UChicago Medicine Northwest Indiana, Crown Point

48038

RECRUITING

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48073

RECRUITING

Corewell Health William Beaumont University Hospital, Royal Oak

48085

RECRUITING

Corewell Health Beaumont Troy Hospital, Troy

48093

RECRUITING

Henry Ford Health Warren Hospital, Warren

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

RECRUITING

Huron Gastroenterology PC, Ypsilanti

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48124

RECRUITING

Corewell Health Dearborn Hospital, Dearborn

48126

RECRUITING

Henry Ford Medical Center-Fairlane, Dearborn

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48183

RECRUITING

Henry Ford Cancer Institute-Downriver, Brownstown

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48192

RECRUITING

Henry Ford Wyandotte Hospital, Wyandotte

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48201

ACTIVE_NOT_RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48202

RECRUITING

Henry Ford Hospital, Detroit

48236

RECRUITING

Henry Ford Health Saint John Hospital, Detroit

48322

RECRUITING

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

ACTIVE_NOT_RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

48336

RECRUITING

Corewell Health Farmington Hills Hospital, Farmington Hills

48341

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48377

RECRUITING

Henry Ford Medical Center-Columbus, Novi

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48910

ACTIVE_NOT_RECRUITING

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing

49007

RECRUITING

Bronson Methodist Hospital, Kalamazoo

RECRUITING

West Michigan Cancer Center, Kalamazoo

49017

RECRUITING

Bronson Battle Creek, Battle Creek

49085

RECRUITING

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

RECRUITING

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

RECRUITING

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49201

RECRUITING

Allegiance Health, Jackson

49444

RECRUITING

Trinity Health Muskegon Hospital, Muskegon

RECRUITING

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

RECRUITING

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

RECRUITING

University of Michigan Health - West, Wyoming

49677

RECRUITING

Corewell Health Reed City Hospital, Reed City

49684

RECRUITING

Munson Medical Center, Traverse City

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50036

RECRUITING

McFarland Clinic - Boone, Boone

50129

RECRUITING

McFarland Clinic - Jefferson, Jefferson

50158

RECRUITING

McFarland Clinic - Marshalltown, Marshalltown

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50266

RECRUITING

Mercy Medical Center-West Lakes, West Des Moines

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

Broadlawns Medical Center, Des Moines

RECRUITING

Mercy Medical Center - Des Moines, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

RECRUITING

Mercy Cancer Center-West Lakes, Clive

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50501

RECRUITING

McFarland Clinic - Trinity Cancer Center, Fort Dodge

50801

RECRUITING

Greater Regional Medical Center, Creston

51401

RECRUITING

Saint Anthony Regional Hospital, Carroll

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

55101

RECRUITING

Regions Hospital, Saint Paul

55337

RECRUITING

Minnesota Oncology - Burnsville, Burnsville

55379

RECRUITING

Saint Francis Regional Medical Center, Shakopee

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55435

RECRUITING

Fairview Southdale Hospital, Edina

55805

ACTIVE_NOT_RECRUITING

Saint Luke's Hospital of Duluth, Duluth

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

57701

RECRUITING

Rapid City Regional Hospital, Rapid City

59102

RECRUITING

Saint Vincent Frontier Cancer Center, Billings

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60426

RECRUITING

Ingalls Memorial Hospital, Harvey

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

Northwestern Medicine Orland Park, Orland Park

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60504

RECRUITING

Rush-Copley Medical Center, Aurora

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60560

RECRUITING

Rush-Copley Healthcare Center, Yorkville

60611

RECRUITING

Northwestern University, Chicago

60637

ACTIVE_NOT_RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

61114

RECRUITING

UW Health Carbone Cancer Center Rockford, Rockford

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63128

RECRUITING

Mercy Hospital South, St Louis

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

64804

RECRUITING

Mercy Hospital Joplin, Joplin

65807

RECRUITING

CoxHealth South Hospital, Springfield

70006

RECRUITING

East Jefferson General Hospital, Metairie

RECRUITING

LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie

70112

RECRUITING

University Medical Center New Orleans, New Orleans

70805

RECRUITING

LSU Health Baton Rouge-North Clinic, Baton Rouge

70808

RECRUITING

Our Lady of the Lake Physician Group, Baton Rouge

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

73120

RECRUITING

Mercy Hospital Oklahoma City, Oklahoma City

73505

RECRUITING

Cancer Centers of Southwest Oklahoma Research, Lawton

75080

RECRUITING

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75235

RECRUITING

Parkland Memorial Hospital, Dallas

75237

RECRUITING

UT Southwestern Simmons Cancer Center - RedBird, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

RECRUITING

Ben Taub General Hospital, Houston

80138

RECRUITING

AdventHealth Parker, Parker

80210

RECRUITING

AdventHealth Porter, Denver

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

85004

RECRUITING

Cancer Center at Saint Joseph's, Phoenix

85054

RECRUITING

Mayo Clinic Hospital in Arizona, Phoenix

90027

RECRUITING

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90034

RECRUITING

Kaiser Permanente West Los Angeles, Los Angeles

90706

RECRUITING

Kaiser Permanente-Bellflower, Bellflower

90710

RECRUITING

Kaiser Permanente South Bay, Harbor City

91367

RECRUITING

Kaiser Permanente-Woodland Hills, Woodland Hills

91402

RECRUITING

Kaiser Permanente - Panorama City, Panorama City

91706

RECRUITING

Kaiser Permanente-Baldwin Park, Baldwin Park

91761

RECRUITING

Kaiser Permanente-Ontario, Ontario

92078

RECRUITING

Kaiser Permanente-San Marcos, San Marcos

92120

RECRUITING

Kaiser Permanente-San Diego Zion, San Diego

92335

RECRUITING

Kaiser Permanente-Fontana, Fontana

92505

RECRUITING

Kaiser Permanente-Riverside, Riverside

92618

RECRUITING

Kaiser Permanente-Irvine, Irvine

92806

RECRUITING

Kaiser Permanente-Anaheim, Anaheim

94040

SUSPENDED

Palo Alto Medical Foundation-Camino Division, Mountain View

94086

SUSPENDED

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

RECRUITING

California Pacific Medical Center-Pacific Campus, San Francisco

94301

SUSPENDED

Palo Alto Medical Foundation Health Care, Palo Alto

94538

RECRUITING

Palo Alto Medical Foundation-Fremont, Fremont

94589

RECRUITING

Sutter Solano Medical Center/Cancer Center, Vallejo

94704

RECRUITING

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95065

RECRUITING

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95355

SUSPENDED

Memorial Medical Center, Modesto

95403

RECRUITING

Sutter Pacific Medical Foundation, Santa Rosa

95602

RECRUITING

Sutter Auburn Faith Hospital, Auburn

95603

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn

95608

RECRUITING

Mercy Cancer Center - Carmichael, Carmichael

RECRUITING

Mercy San Juan Medical Center, Carmichael

95661

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

RECRUITING

Sutter Roseville Medical Center, Roseville

95682

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park

95695

RECRUITING

Woodland Memorial Hospital, Woodland

95758

RECRUITING

Mercy Cancer Center - Elk Grove, Elk Grove

95765

RECRUITING

Mercy Cancer Center - Rocklin, Rocklin

95816

RECRUITING

Mercy Cancer Center - Sacramento, Sacramento

RECRUITING

Sutter Medical Center Sacramento, Sacramento

96701

RECRUITING

Hawaii Cancer Care - Westridge, ‘Aiea

RECRUITING

Pali Momi Medical Center, ‘Aiea

96706

RECRUITING

The Queen's Medical Center - West Oahu, ‘Ewa Beach

96813

RECRUITING

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

RECRUITING

Queen's Cancer Cenrer - POB I, Honolulu

RECRUITING

Queen's Medical Center, Honolulu

RECRUITING

Straub Clinic and Hospital, Honolulu

96817

RECRUITING

Queen's Cancer Center - Kuakini, Honolulu

97015

SUSPENDED

Providence Cancer Institute Clackamas Clinic, Clackamas

97045

RECRUITING

Providence Willamette Falls Medical Center, Oregon City

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

97701

RECRUITING

Saint Charles Health System, Bend

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

98195

RECRUITING

University of Washington Medical Center - Montlake, Seattle

99508

RECRUITING

Alaska Women's Cancer Care, Anchorage

06418

RECRUITING

Smilow Cancer Hospital-Derby Care Center, Derby

06824

RECRUITING

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06033

RECRUITING

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury

06830

RECRUITING

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

RECRUITING

Smilow Cancer Hospital Care Center - Guilford, Guilford

06105

RECRUITING

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06520

RECRUITING

Yale University, New Haven

06473

RECRUITING

Yale-New Haven Hospital North Haven Medical Center, North Haven

06902

RECRUITING

Smilow Cancer Hospital Care Center at Long Ridge, Stamford

06790

RECRUITING

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

RECRUITING

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

RECRUITING

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

RECRUITING

Smilow Cancer Hospital Care Center - Waterford, Waterford

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

03756

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

02891

RECRUITING

Smilow Cancer Hospital Care Center - Westerly, Westerly

05819

RECRUITING

Dartmouth Cancer Center - North, Saint Johnsbury

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH