716
Participants
Start Date
September 30, 2021
Primary Completion Date
February 7, 2024
Study Completion Date
February 7, 2024
Sodium Zirconium Cyclosilicate (SZC)
"Powder for oral suspension in a sachet. Unit dose strength: 5 or 10 g SZC. Single dose will consist of 1-3 sachets.~During Initiation Phase:~* S-K \> 5 to ≤ 6.5 mmol/L (measured by L-Lab): Single dose contains 10 g SZC that should be suspended in 45 mL of water. The 10 g SZC single dose should be administered three times daily for up to 72 hours until normokalaemic (S-K 3.5-5.0 mmol/L); the total daily dose is 30 g SZC.~* S-K ≥ 3.5 to ≤ 5 mmol/L (measured by L-Lab): Single dose contains 5 g SZC that should be suspended in 45 mL of water and administered once daily for 48 hours.~During Run-in and Maintenance Phases:~\- Single dose contains 5 g SZC administered every other day or 5, 10, or 15 g SZC administered once daily that should be suspended in 45 mL of water."
Placebo
"Powder for oral suspension in a sachet. Placebo to match 5 or 10 g. Single dose will consist of 1-3 sachets.~During Maintenance Phase:~\- Single dose contains 5 g placebo administered every other day or 5, 10, or 15 g placebo administered once daily that should be suspended in 45 mL of water."
Lisinopril
Tablet for oral administration. Unit dose strength: 2.5, 5, 10 or 20 mg. Dosage level: 5, 10, 20, or 40 mg administered once daily.
Valsartan
Tablet or capsule for oral administration. Unit dose strength: 40, 80 or 160 mg. Dosage level: 40, 80, 160, or 320 mg administered once daily.
Irbesartan
"Tablet for oral administration. Unit dose strength: 75, 150 or 300 mg. Dosage level: 75, 150, or 300 mg administered once daily.~The study is designed to use valsartan as the selected ARB therapy adjunct to SZC. However, if an actual shortage of valsartan in a local market jeopardises the ability of participants to enter or continue in the study, valsartan can be temporarily substituted with irbesartan until the shortage of valsartan is resolved."
Research Site, Taipei
Research Site, Taipei
Research Site, Taoyuan District
Research Site, Tainan City
Research Site, Kaohsiung City
Research Site, La Plata
Research Site, Rosario
Research Site, Samokov
Research Site, Botevgrad
Research Site, Dupnitsa
Research Site, Blagoevgrad
Research Site, Sandanski
Research Site, Gotse Delchev
Research Site, Kozloduy
Research Site, Lom
Research Site, Smolyan
Research Site, Plovdiv
Research Site, Plovdiv
Research Site, Plovdiv
Research Site, Almería
Research Site, Iloilo City
Research Site, San Vicente
Research Site, Gorna Oryahovitsa
Research Site, Alor Star
Research Site, Pleven
Research Site, Stara Zagora
Research Site, Ankara
Research Site, Silistra
Research Site, Mar del Plata
Research Site, Barcelona
Research Site, Yambol
Research Site, Sliven
Research Site, Ho Chi Minh City
Research Site, Taipei
Research Site, Zhytomyr
Research Site, Bangkok
Research Site, Ratchathewi
Research Site, Bangkok
Research Site, Great Neck
Research Site, Albany
Research Site, Bethlehem
Research Site, Chester
Research Site, Rozzano
Research Site, Keelung
Research Site, Vinnytsia
Research Site, New Taipei City
Research Site, Newport News
Research Site, Brescia
Research Site, Lugo
Research Site, Pavia
Research Site, Winston-Salem
Research Site, Gaziantep
Research Site, Madrid
Research Site, Getafe
Research Site, Orangeburg
Research Site, Columbia
Research Site, Seri Manjung
Research Site, Hialeah
Research Site, Lauderdale Lakes
Research Site, Boynton Beach
Research Site, Temple Terrace
Research Site, Ocoee
Research Site, Izmir
Research Site, Bassano del Grappa
Research Site, Verona
Research Site, Chattanooga
Research Site, Santa Cruz de Tenerife
Research Site, Kayseri
Research Site, Bologna
Research Site, Taichung
Research Site, Louisville
Research Site, Taichung
Research Site, Seville
Research Site, Kocaeli
Research Site, Kajang
Research Site, Lutsk
Research Site, Guadalajara
Research Site, Cincinnati
Research Site, Valencia
Research Site, Valencia
Research Site, Kahramanmaraş
Research Site, Fort Wayne
Research Site, Saint Clair Shores
Research Site, Flint
Research Site, Dnipropetrovsk
Research Site, Chaingmai
Research Site, Kuala Lumpur
Research Site, Adapazarı
Research Site, Da Nang
Research Site, Kuala Lumpur
Research Site, Kuala Lumpur
Research Site, Oak Brook
Research Site, Chicago
Research Site, Kharkiv
Research Site, Kansas City
Research Site, Columbia
Research Site, Batu Caves
Research Site, Zaporizhzhia
Research Site, Ho Chi Minh City
Research Site, Bari
Research Site, Tainan City
Research Site, San Giovanni Rotondo
Research Site, Arlington
Research Site, Fort Worth
Research Site, Houston
Research Site, Houston
Research Site, Houston
Research Site, San Antonio
Research Site, San Luis Potosí City
Research Site, Johor Bahru
Research Site, Denver
Research Site, Culiacán
Research Site, Kaohsiung City
Research Site, Mazatlán
Research Site, Kaohsiung City
Research Site, Nampa
Research Site, Surprise
Research Site, Tucson
Research Site, Albuquerque
Research Site, Hat Yai
Research Site, South Gate
Research Site, Northridge
Research Site, Canyon Country
Research Site, Tarzana
Research Site, San Dimas
Research Site, Veracruz
Research Site, Chula Vista
Research Site, Hualien City
Research Site, Mérida
Research Site, Mérida
Research Site, Messina
Research Site, Hanoi
Research Site, Beijing
Research Site, Beijing
Research Site, Beijing
Research Site, Beijing
Research Site, Beijing
Research Site, Beijing
Research Site, Shenyang
Research Site, Shengyang
Research Site, New Delhi
Research Site, Moscow
Research Site, Changchun
Research Site, Saint Petersburg
Research Site, Shanghai
Research Site, Shanghai
Research Site, Shanghai
Research Site, Shanghai
Research Site, Nanjing
Research Site, Nanjing
Research Site, Nanjing
Research Site, Wuxi
Research Site, New Taipei City
Research Site, Xuzhou
Research Site, Hefei
Research Site, Yantai
Research Site, Hangzhou
Research Site, Ningbo
Research Site, Nanchang
Research Site, Rostov-on-Don
Research Site, Chongqing
Research Site, Changsha
Research Site, Zhuzhou
Research Site, Hengyang
Research Site, Wuhan
Research Site, Wuhan
Research Site, Guangzhou
Research Site, Guangzhou
Research Site, Guangzhou
Research Site, Guangzhou
Research Site, Shantou
Research Site, Huizhou
Research Site, Shenzhen
Research Site, Huế
Research Site, Guiyang
Research Site, Sanya
Research Site, Chengdu
Research Site, Chengdu
Research Site, Perm
Research Site, Aramil
Research Site, Madurai
Research Site, Coimbatore
Research Site, Ho Chi Minh City
Research Site, Kolkata
Research Site, Xi'an
Research Site, Lanzhou
Research Site, Yinchuan
Research Site, Biên Hòa
Research Site, Ürümqi
Research Site, Fortaleza
Research Site, Boston
Research Site, Boston
Research Site, Buenos Aires
Research Site, Buenos Aires
Research Site, CABA
Research Site, Mar del Plata
Research Site, Sarandí
Research Site, Curitiba
Research Site, Joinville
Research Site, Maringá
Research Site, Porto Alegre
Research Site, Porto Alegre
Research Site, São Paulo
Research Site, São Paulo
Research Site, Saint John
Research Site, Oshawa
Research Site, Montreal
Research Site, Montreal
Research Site, Baotou
Research Site, Taiyuan
Research Site, Zhengzhou
Research Site, Istanbul
Research Site, Roma
Research Site, Roma
Research Site, Amagasaki-shi
Research Site, Atsugi-shi
Research Site, Chiba
Research Site, Chuo-shi
Research Site, Chūōku
Research Site, Chūōku
Research Site, Fukuoka
Research Site, Kamakura-shi
Research Site, Kanoya-shi
Research Site, Kasugai-shi
Research Site, Kawachinagano-shi
Research Site, Kawasaki-shi
Research Site, Kitakyushu
Research Site, Kitakyushu-shi
Research Site, Koriyama-shi
Research Site, Koshigaya-shi
Research Site, Kumamoto
Research Site, Kure-shi
Research Site, Marugame-shi
Research Site, Matsumoto-shi
Research Site, Matsusaka-shi
Research Site, Matsuyama
Research Site, Nagoya
Research Site, Nagoya
Research Site, Naka
Research Site, Noda
Research Site, Osaka
Research Site, Osaka
Research Site, Ōita
Research Site, Ōmihachiman
Research Site, Sakaishi
Research Site, Takarazuka-shi
Research Site, Toyota
Research Site, Toyota-Shi
Research Site, Tsu
Research Site, Tsuchiura-shi
Research Site, Urayasu-shi
Research Site, Yaizu-shi
Research Site, Yokohama
Research Site, Yokohama
Research Site, Yokohama
Research Site, Yonago-shi
Research Site, Cuauhtémoc
Research Site, México
Research Site, México
Research Site, Davao City
Research Site, Krakow
Research Site, Lodz
Research Site, Poznan
Research Site, Rzeszów
Research Site, Tczew
Research Site, Ponce
Research Site, Barcelona
Research Site, Barcelona
Research Site, L'Hospitalet de Llobregat
Research Site, Ankara
Research Site, Ankara
Research Site, Antalya
Research Site, Kyiv
Research Site, Kyiv
Research Site, Kyiv
Research Site, Kyiv
Lead Sponsor
AstraZeneca
INDUSTRY