PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy

PHASE3RecruitingINTERVENTIONAL
Enrollment

396

Participants

Timeline

Start Date

May 1, 2022

Primary Completion Date

December 1, 2027

Study Completion Date

December 1, 2032

Conditions
Esophageal CancerRadiotherapySide EffectProton Therapy
Interventions
RADIATION

Photon Radiotherapy

nCXT consists of weekly carboplatin and paclitaxel for 5 weeks, following the CROSS trial. The radiation dose will be either 41.4 Gy in 23 fractions or 50.4 Gy in 28 fractions

RADIATION

Proton Radiotherapy

nCPT consists of weekly carboplatin and paclitaxel for 5 weeks, following the CROSS trial. The radiation dose will be either 41.4 Gy in 23 fractions or 50.4 Gy in 28 fractions

Trial Locations (15)

8000

RECRUITING

Aarhus University Hospital (AUH), Aarhus

8091

RECRUITING

University Hospital Zurich (USZ), Zurich

Unknown

RECRUITING

Catholic University of Leuven, Leuven

NOT_YET_RECRUITING

Centre Léon Bérard (CLB), Lyon

NOT_YET_RECRUITING

Centre Antoine Lacassagne (CAL), Nice

NOT_YET_RECRUITING

Institut Curie, Paris

RECRUITING

Technische Universität Dresden (TUD), Dresden

RECRUITING

San Raffaele Hospital, Milan

RECRUITING

Centro Nazionale di Adroterapia Oncologica (CNAO), Pavia

RECRUITING

Azienda Provinciale Per I Servizi Sanitari (APSS), Trento

WITHDRAWN

Academisch Ziekenhuis Groningen (UMCG), Groningen

WITHDRAWN

Stichting Maastricht Radiation Oncology (MAASTRO), Maastricht

RECRUITING

Paul Scherrer Institute (PSI), Villigen

WITHDRAWN

University College London Hospital (UCLH), London

NOT_YET_RECRUITING

The Christie NHS foundation trust, Manchester

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University of Leeds

OTHER

collaborator

KU Leuven

OTHER

collaborator

University College, London

OTHER

collaborator

Aarhus University Hospital

OTHER

collaborator

Technische Universität Dresden

OTHER

collaborator

Academisch Ziekenhuis Groningen

OTHER

collaborator

CNAO National Center of Oncological Hadrontherapy

OTHER

collaborator

Agenzia Nazionale per i Servizi Sanitari Regionali

OTHER

collaborator

Centre Antoine Lacassagne

OTHER

collaborator

Centre Leon Berard

OTHER

collaborator

Institut Curie

OTHER

collaborator

Maastro Clinic, The Netherlands

OTHER

collaborator

University College London Hospitals

OTHER

collaborator

The Christie NHS Foundation Trust

OTHER

collaborator

Paul Scherrer Institut, Center for Proton Therapy

OTHER

collaborator

HollandPTC

INDUSTRY

collaborator

IBA worldwide

UNKNOWN

collaborator

Varian- A Siemens Healthineer Company

UNKNOWN

lead

University of Aarhus

OTHER

NCT05055648 - PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy | Biotech Hunter | Biotech Hunter