Testing the Addition of the Drug Relugolix to the Usual Radiation Therapy for Advanced-Stage Prostate Cancer, The NRG Promethean Study

PHASE2RecruitingINTERVENTIONAL
Enrollment

194

Participants

Timeline

Start Date

April 20, 2022

Primary Completion Date

February 1, 2029

Study Completion Date

February 1, 2029

Conditions
Oligometastatic Prostate CarcinomaProstate AdenocarcinomaProstate Ductal AdenocarcinomaProstate Intraductal CarcinomaStage IVB Prostate Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo urine and blood sample collection

PROCEDURE

Bone Scan

Undergo bone scan

PROCEDURE

Computed Tomography

Undergo CT and/or PET/CT

OTHER

Fluciclovine F18

Given fluciclovine F18

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI and/or PET/MRI

DRUG

Placebo Administration

Given PO

PROCEDURE

Positron Emission Tomography

Undergo PET/CT and/or PET/MRI

PROCEDURE

PSMA PET Scan

Undergo PSMA PET/CT or PET/MRI

DRUG

Relugolix

Given PO

RADIATION

Stereotactic Body Radiation Therapy

Undergo SABR

Trial Locations (229)

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

14580

RECRUITING

Wilmot Cancer Institute at Webster, Webster

14620

RECRUITING

Highland Hospital, Rochester

14642

RECRUITING

University of Rochester, Rochester

15009

RECRUITING

UPMC-Heritage Valley Health System Beaver, Beaver

15108

RECRUITING

UPMC Hillman Cancer Center in Coraopolis, Moon Township

15213

RECRUITING

UPMC-Magee Womens Hospital, Pittsburgh

15215

RECRUITING

UPMC-Saint Margaret, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

RECRUITING

UPMC-Shadyside Hospital, Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

15301

RECRUITING

UPMC Washington Hospital Radiation Oncology, Washington

15701

RECRUITING

IRMC Cancer Center, Indiana

16121

RECRUITING

UPMC Cancer Center at UPMC Horizon, Farrell

16346

RECRUITING

UPMC Cancer Center at UPMC Northwest, Seneca

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

16601

RECRUITING

UPMC Altoona, Altoona

17015

RECRUITING

Carlisle Regional Cancer Center, Carlisle

17042

RECRUITING

Sechler Family Cancer Center, Lebanon

17050

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

17109

RECRUITING

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17201

RECRUITING

Chambersburg Hospital, Chambersburg

17325

RECRUITING

Adams Cancer Center, Gettysburg

17403

RECRUITING

WellSpan Health-York Cancer Center, York

17408

RECRUITING

UPMC Memorial, York

17522

RECRUITING

Ephrata Cancer Center, Ephrata

17754

RECRUITING

Divine Providence Hospital, Williamsport

17822

RECRUITING

Geisinger Medical Center, Danville

17837

RECRUITING

Geisinger Medical Oncology-Lewisburg, Lewisburg

17901

RECRUITING

Geisinger Cancer Services-Pottsville, Pottsville

18711

RECRUITING

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

18925

ACTIVE_NOT_RECRUITING

Fox Chase Cancer Center Buckingham, Furlong

19010

RECRUITING

Bryn Mawr Hospital, Bryn Mawr

19063

RECRUITING

Riddle Memorial Hospital, Media

19096

RECRUITING

Lankenau Medical Center, Wynnewood

19111

ACTIVE_NOT_RECRUITING

Fox Chase Cancer Center, Philadelphia

19301

RECRUITING

Paoli Memorial Hospital, Paoli

19317

RECRUITING

Christiana Care Health System-Concord Health Center, Chadds Ford

19401

ACTIVE_NOT_RECRUITING

Fox Chase Cancer Center - East Norriton Hospital Outpatient Center, East Norriton

19713

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

19967

RECRUITING

Beebe South Coastal Health Campus, Millville

19971

RECRUITING

Beebe Health Campus, Rehoboth Beach

20037

RECRUITING

George Washington University Medical Center, Washington D.C.

23114

RECRUITING

Bon Secours Saint Francis Medical Center, Midlothian

23230

RECRUITING

Bon Secours Cancer Institute at Reynolds Crossing, Richmond

23235

RECRUITING

VCU Massey Cancer Center at Stony Point, Richmond

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

23970

RECRUITING

VCU Community Memorial Health Center, South Hill

25701

RECRUITING

Edwards Comprehensive Cancer Center, Huntington

27834

RECRUITING

East Carolina University, Greenville

29401

RECRUITING

Ralph H Johnson VA Medical Center, Charleston

29577

SUSPENDED

Carolina Regional Cancer Center, Myrtle Beach

30033

RECRUITING

Emory Decatur Hospital, Decatur

30097

RECRUITING

Emory Johns Creek Hospital, Johns Creek

30106

RECRUITING

WellStar Cobb Hospital, Austell

30214

SUSPENDED

Piedmont Fayette Hospital, Fayetteville

30303

RECRUITING

Grady Health System, Atlanta

30308

RECRUITING

Emory University Hospital Midtown, Atlanta

30309

SUSPENDED

Piedmont Hospital, Atlanta

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

RECRUITING

Emory Saint Joseph's Hospital, Atlanta

32701

RECRUITING

AdventHealth Altamonte, Altamonte Springs

32803

RECRUITING

AdventHealth Orlando, Orlando

33324

SUSPENDED

GenesisCare USA - Plantation, Plantation

33331

RECRUITING

Cleveland Clinic-Weston, Weston

33458

ACTIVE_NOT_RECRUITING

Jupiter Medical Center, Jupiter

33607

RECRUITING

Moffitt Cancer Center-International Plaza, Tampa

33612

RECRUITING

Moffitt Cancer Center - McKinley Campus, Tampa

RECRUITING

Moffitt Cancer Center, Tampa

34202

SUSPENDED

GenesisCare USA - Lakewood Ranch, Lakewood Rch

34747

RECRUITING

AdventHealth Celebration, Celebration

40202

RECRUITING

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

RECRUITING

UofL Health Medical Center Northeast, Louisville

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

43560

RECRUITING

ProMedica Flower Hospital, Sylvania

44011

ACTIVE_NOT_RECRUITING

UH Seidman Cancer Center at UH Avon Health Center, Avon

44060

ACTIVE_NOT_RECRUITING

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

ACTIVE_NOT_RECRUITING

Case Western Reserve University, Cleveland

44111

RECRUITING

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

ACTIVE_NOT_RECRUITING

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

RECRUITING

Hillcrest Hospital Cancer Center, Mayfield Heights

44129

ACTIVE_NOT_RECRUITING

University Hospitals Parma Medical Center, Parma

44136

RECRUITING

Cleveland Clinic Cancer Center Strongsville, Strongsville

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

44266

ACTIVE_NOT_RECRUITING

University Hospitals Portage Medical Center, Ravenna

45373

RECRUITING

Upper Valley Medical Center, Troy

45409

RECRUITING

Miami Valley Hospital, Dayton

RECRUITING

Premier Blood and Cancer Center, Dayton

45415

RECRUITING

Miami Valley Hospital North, Dayton

45459

RECRUITING

Miami Valley Hospital South, Centerville

46526

RECRUITING

Goshen Center for Cancer Care, Goshen

46845

ACTIVE_NOT_RECRUITING

Parkview Regional Medical Center, Fort Wayne

48044

RECRUITING

Michigan Healthcare Professionals Macomb, Macomb

48071

RECRUITING

Michigan Healthcare Professionals Madison Heights, Madison Heights

48073

RECRUITING

Corewell Health William Beaumont University Hospital, Royal Oak

48085

RECRUITING

Corewell Health Beaumont Troy Hospital, Troy

48098

RECRUITING

Michigan Healthcare Professionals Troy, Troy

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48334

RECRUITING

Michigan Healthcare Professionals Farmington, Farmington Hills

48341

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48346

RECRUITING

Michigan Healthcare Professionals Clarkston, Clarkston

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

49007

RECRUITING

Bronson Methodist Hospital, Kalamazoo

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

RECRUITING

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

RECRUITING

University of Michigan Health - West, Wyoming

49684

RECRUITING

Munson Medical Center, Traverse City

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

53024

RECRUITING

Aurora Cancer Care-Grafton, Grafton

53051

RECRUITING

Froedtert Menomonee Falls Hospital, Menomonee Falls

53066

RECRUITING

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

RECRUITING

Aurora Medical Center in Summit, Summit

53081

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53095

RECRUITING

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53149

RECRUITING

ProHealth D N Greenwald Center, Mukwonago

53154

RECRUITING

Drexel Town Square Health Center, Oak Creek

53188

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

53215

RECRUITING

Aurora Saint Luke's Medical Center, Milwaukee

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

RECRUITING

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

RECRUITING

Aurora West Allis Medical Center, West Allis

53233

RECRUITING

Aurora Sinai Medical Center, Milwaukee

54017

RECRUITING

Cancer Center of Western Wisconsin, New Richmond

54143

RECRUITING

Aurora Bay Area Medical Group-Marinette, Marinette

54311

RECRUITING

Aurora BayCare Medical Center, Green Bay

54401

RECRUITING

Aspirus Regional Cancer Center, Wausau

54409

RECRUITING

Langlade Hospital and Cancer Center, Antigo

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54481

RECRUITING

Aspirus Cancer Care - Stevens Point, Stevens Point

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

RECRUITING

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54501

RECRUITING

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

54904

RECRUITING

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55101

RECRUITING

Regions Hospital, Saint Paul

57104

RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

60010

RECRUITING

Advocate Good Shepherd Hospital, Barrington

60014

RECRUITING

AMG Crystal Lake - Oncology, Crystal Lake

60048

RECRUITING

AMG Libertyville - Oncology, Libertyville

60068

RECRUITING

Advocate Lutheran General Hospital, Park Ridge

60123

RECRUITING

Advocate Sherman Hospital, Elgin

60429

RECRUITING

Advocate South Suburban Hospital, Hazel Crest

60515

RECRUITING

Advocate Good Samaritan Hospital, Downers Grove

60657

RECRUITING

Advocate Illinois Masonic Medical Center, Chicago

61636

RECRUITING

Methodist Medical Center of Illinois, Peoria

61637

RECRUITING

OSF Saint Francis Medical Center, Peoria

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

RECRUITING

Alton Memorial Hospital, Alton

62269

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

RECRUITING

Memorial Hospital East, Shiloh

62401

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Decatur Memorial Hospital, Decatur

62781

RECRUITING

Springfield Memorial Hospital, Springfield

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

65401

RECRUITING

Phelps Health Delbert Day Cancer Institute, Rolla

70002

RECRUITING

Mary Bird Perkins Cancer Center - Metairie, Metairie

70006

RECRUITING

East Jefferson General Hospital, Metairie

RECRUITING

LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie

70112

RECRUITING

University Medical Center New Orleans, New Orleans

70809

RECRUITING

Mary Bird Perkins Cancer Center, Baton Rouge

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

79410

RECRUITING

Covenant Medical Center-Lakeside, Lubbock

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

80122

RECRUITING

AdventHealth Littleton, Littleton

80129

RECRUITING

UCHealth Highlands Ranch Hospital, Highlands Ranch

80304

RECRUITING

Rocky Mountain Cancer Centers-Boulder, Boulder

80524

RECRUITING

Poudre Valley Hospital, Fort Collins

80528

RECRUITING

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

RECRUITING

Medical Center of the Rockies, Loveland

80539

SUSPENDED

Banner McKee Medical Center, Loveland

80631

SUSPENDED

Banner North Colorado Medical Center, Greeley

RECRUITING

UCHealth Greeley Hospital, Greeley

80909

RECRUITING

UCHealth Memorial Hospital Central, Colorado Springs

80920

RECRUITING

Memorial Hospital North, Colorado Springs

81632

RECRUITING

Shaw Cancer Center, Edwards

85004

RECRUITING

Cancer Center at Saint Joseph's, Phoenix

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

90033

ACTIVE_NOT_RECRUITING

Los Angeles General Medical Center, Los Angeles

ACTIVE_NOT_RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

90211

RECRUITING

Tower Cancer Research Foundation, Beverly Hills

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94589

RECRUITING

Sutter Solano Medical Center/Cancer Center, Vallejo

94704

RECRUITING

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95355

RECRUITING

Memorial Medical Center, Modesto

95403

RECRUITING

Sutter Pacific Medical Foundation, Santa Rosa

97239

RECRUITING

Oregon Health and Science University, Portland

98034

RECRUITING

FHCC at EvergreenHealth, Kirkland

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

98133

RECRUITING

FHCC at Northwest Hospital, Seattle

98195

RECRUITING

University of Washington Medical Center - Montlake, Seattle

60453-2699

RECRUITING

Advocate Christ Medical Center, Oak Lawn

03756

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07652

RECRUITING

The Valley Hospital - Luckow Pavilion, Paramus

45005-1066

RECRUITING

Atrium Medical Center-Middletown Regional Hospital, Franklin

17033-0850

RECRUITING

Penn State Milton S Hershey Medical Center, Hershey

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

05602

RECRUITING

Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners

05401

RECRUITING

University of Vermont Medical Center, Burlington

05819

RECRUITING

Dartmouth Cancer Center - North, Saint Johnsbury

M5G 2M9

RECRUITING

University Health Network-Princess Margaret Hospital, Toronto

H2X 3E4

RECRUITING

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal

G1R 2J6

RECRUITING

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER