547
Participants
Start Date
March 7, 2022
Primary Completion Date
June 20, 2025
Study Completion Date
June 20, 2026
Bemarituzumab
Intravenous (IV) infusion
mFOLFOX6
mFOLFOX6 administered as a combination of oxaliplatin and leucovorin as IV infusions. 5-FU administered as bolus followed by additional administration as IV infusion.
Placebo
IV infusion
St James Hospital, Dublin
Pauls Stradins Clinical University Hospital, Riga
Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD, Sofia
Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia
Sandton Oncology Centre, Gauteng
Rigshospitalet, Copenhagen
Liverpool Hospital, Liverpool
Netcare Milpark Hospital, Johannesburg
Universitair Ziekenhuis Antwerpen, Edegem
Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven
Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz, Miskolc
Exelsus Oncologia Clinica, San Miguel de Tucumán
Centre Hospitalier Universitaire de Liege - Sart Tilman, Liège
The Oncology Centre, Durban
University Multiprofile Hospital for Active Treatment Pulmed OOD, Plovdiv
Multiprofile Hospital for Active Treatment Park Hospital EOOD, Branipole Village
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz, Nyíregyháza
Sociedad de Beneficencia Hospital Italiano, Córdoba
Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz, Gyula
University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD, Pleven
St John of God Murdoch Hospital, Murdoch
Specialized Hospital for Active Treatment of Oncology - Haskovo EOOD, Haskovo
Tolna Varmegyei Balassa Janos Korhaz, Szekszárd
Universitair Ziekenhuis Gent, Ghent
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz, Győr
Azienda Ospedaliera Ordine Mauriziano di Torino, Torino
King Chulalongkorn Memorial Hospital, Bangkok
Rajavithi Hospital, Bangkok
Ramathibodi Hospital, Bangkok
National Cancer Center, Goyang-si Gyeonggi-do
White Plains Hospital Center for Cancer Care, White Plains
Siriraj Hospital, Bangkok
Healthier Hematology and Oncology Excelsior Integrated Medical Group, Brooklyn
Tri-Service General Hospital, Taipei
Agios Savvas Anticancer Hospital, Athens
251 General Airforce Hospital, Athens
General Hospital of Athens Laiko, Athens
Evgenidio Hospital I Agia Trias, Athens
Centro de Investigacion Clinica Trujillo Eirl, Trujillo
North Estonia Medical Centre Foundation, Tallinn
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do
Hospital Universitario Reina Sofia, Córdoba
Instituto Peruano de Oncologia y Radioterapia, San Isidro
Oncosalud, Lima
Metropolitan Hospital, Athens
Investigación Biomédica para el Desarrollo de Fármacos, Aguascalientes
Hospital Donostia, Donostia / San Sebastian
IRCCS Istituto Clinico Humanitas, Rozzano MI
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan
Dicle Universitesi Tip Fakultesi, Diyarbakır
The Catholic University of Korea Incheon St Marys Hospital, Incheon
Centro Oncologico Internacional, Tijuana
Inova Schar Cancer Institute, Fairfax
Centre Hospitalier Régional Universitaire de Besançon, Hôpital Jean Minjoz, Besançon
Istituto Ospedaliero Fondazione Poliambulanza, Brescia
University Hospital of Patras, Pátrai
Hospital General Universitario Gregorio Marañon, Madrid
Levine Cancer Institute University, Charlotte
Hospital Universitario Puerta de Hierro Majadahonda, Madrid
FirstHealth Cancer Center, Pinehurst
Hospital Regional Universitario de Malaga, Málaga
Centre Hospitalier Universitaire de Brest - Cavale Blanche, Brest
Hospital General Universitario Jose Maria Morales Meseguer, Murcia
Complexo Hospitalario Universitario de Ourense, Ourense
Mayo Clinic Florida, Jacksonville
Azienda Sanitaria Universitaria Friuli Centrale Presidio Ospedaliero Santa Maria della Misericordia, Udine
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan District
Bezmialem Vakif Universitesi Hastanesi, Istanbul
Istanbul Universitesi Cerrahpasa Tip Fakultesi, Istanbul
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi, Istanbul
Kartal Dr Lutfi Kirdar Sehir Hastanesi, Istanbul
Chungnam National University Hospital, Daejeon
Izmir Ataturk Egitim ve Arastirma Hastanesi, Izmir
Azienda Ospedaliera Universitaria Integrata di Verona Ospedale Civile Maggiore Borgo Trento, Verona
Vanderbilt University Medical Center, Nashville
China Medical University Hospital, Taichung
University Hospital of Larissa, Larissa
Kocaeli Universitesi Tip Fakultesi Hastanesi, Kocaeli
Kyungpook National University Chilgok Hospital, Daegu
Azienda Unita Saniataria Locale IRCCS di Reggio Emilia, Reggio Emilia
Centre Hospitalier Universitaire Nord de Saint Etienne - Hôpital Nord, Saint-Priest-en-Jarez
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara
Inonu Universitesi Turgut Ozal Tip Merkezi, Malatya
Investigacion Biomedica para el Desarrollo de Farmacos SA de CV, Zapopan
Hospital Universitari i Politecnic La Fe, Valencia
Saint Francis Medical Group, Indianapolis
University of Michigan, Ann Arbor
Dong-A University Hospital, Busan
Hospital Universitario Miguel Servet, Zaragoza
Lietuvos sveikatos mokslu universiteto ligonine viesoji istaiga Kauno klinikos, Kaunas
Hospital Kuala Lumpur, Kuala Lumpur
Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré, Reims
Anticancer Hospital of Thessaloniki Theageneio, Thessaloniki
Sakarya Egitim ve Arastirma Hastanesi, Sakarya
Bioclinic of Thessaloniki, Thessaloniki
Jeonbuk National University Hospital, Jeonju-si, Jeollabuk-do
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi, Samsun
Mayo Clinic Rochester, Rochester
Avera Cancer Institute, Sioux Falls
Centre Hospitalier Régional Universitaire de Lille - Hôpital Claude Huriez, Lille
University Malaya Medical Centre, Kuala Lumpur
Centre Hospitalier Universitaire de Clermont Ferrand, Hôpital Estaing, Clermont-Ferrand
Christus Muguerza Clinica Vidriera, Monterrey
Filios Alta Medicina sa de cv, Monterrey
Van Yuzuncu Yil Universitesi Dursun Odabas Tip Merkezi, Van
Institut de cancerologie Strasbourg Europe, Strasbourg
Centre Leon Berard, Lyon
National Cheng Kung University Hospital, Tainan City
University Hospital of Heraklion, Heraklion - Crete
Azienda Ospedaliera Cardinale Giovanni Panico, Tricase
Azienda Unita Sanitaria Locale LE Presidio Ospedaliero Vito Fazzi Polo Oncologico Giovanni Paolo II, Lecce
Hôpital Européen Georges Pompidou, Paris
Institut Mutualiste Montsouris, Paris
Centre Hospitalier Universitaire Amiens Picardie - Hopital Sud, Amiens
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City
Sainte Catherine - Institut du Cancer d Avignon, Avignon
Mayo Clinic Arizona, Phoenix
University of California Los Angeles, Los Angeles
The Oncology Institute Clinical Research, Cerritos
Viesoji istaiga Klaipedos universitetine ligonine, Klaipėda
Sarawak General Hospital, Kuching
Institut Gustave Roussy, Villejuif
Azienda Ospedaliera di Rilievo Nazionale e Alta Specializzazione Garibaldi Nesima, Catania
Medical Oncology Associates, PS, Spokane
Alaska Oncology and Hematology, Anchorage
Cancer Hospital of Chinese Academy of Medical Sciences, Beijing
Peking Union Medical College Hospital, Beijing
Linfen Central Hospital, Linfen
Beijing Cancer Hospital, Beijing
The First Hospital of China Medical University, Shenyang
Liaoning Cancer Hospital, Shenyang
The First Affiliated Hospital of Jinzhou Medical University, Jinzhou
The First Hospital of Jilin University, Changchun
China-Japan Union Hospital of Jilin University, Changchun
Harbin Medical University Cancer Hospital, Harbin
National Cancer Centre Singapore, Singapore
Sociedad de Oncologia y Hematologia del Cesar, Valledupar
Zhongshan Hospital Fudan University, Shanghai
Shanghai General Hospital, Shanghai
Shanghai East Hospital, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai
Nanjing First Hospital, Nanjing
Affiliated Hospital of Jiangnan University, Wuxi
The Second Affiliated Hospital of Soochow University, Suzhou
The Affiliated Hospital of Xuzhou Medical University, Xuzhou
The First Affiliated Hospital of Anhui Medical University, Hefei
Anhui Provincial Cancer Hospital, Hefei
The First Affiliated Hospital of Bengbu Medical College, Bengbu
Jinan Central Hospital, Jinan
The Affiliated Cancer Hospital of Shandong First Medical University, Jinan
The Affiliated Hospital of Qingdao University, Qingdao
Tianjin Medical University Cancer institute and hospital, Tianjin
The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou
The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou
The First Affiliate Hospital of Ningbo University, Ningbo
Taizhou Hospital of Zhejiang Province, Linhai
Lishui Municipal central Hospital, Lishui
Peoples Hospital of Quzhou, Quzhou
The First Affiliated Hospital of Nanchang University, Nanchang
Fujian Medical University Union Hospital, Fuzhou
Fujian Cancer Hospital, Fuzhou
The First Affiliated Hospital of Xiamen University, Xiamen
Chongqing University Three Gorges Hospital, Chongqing
SC Medisprof SRL, Cluj-Napoca
Xiangya Hospital of Central South University, Changsha
Hunan Cancer Hospital, Changsha
The Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Tech, Wuhan
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of ScienceandTechnology, Wuhan
Spitalul Judetean de Urgenta Dr Constantin Opris Baia Mare, Baia Mare
Hubei Cancer Hospital, Wuhan
Taihe Hospital Affiliated Hospital of Hubei University of Medicine, Shiyan
Henan Cancer Hospital, Zhengzhou
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
Anyang Cancer Hospital, Anyang
The First Affiliated Hospital of Henan University of science and Technology, Luoyang
Sun Yat-sen University Cancer Center, Guangzhou
Guangdong Provincial Peoples Hospital, Guangzhou
Sun Yat-sen University Cancer Center, Guangzhou
Cancer Hospital of Shantou University Medical College, Shantou
Instituto Cancerologico de Narino Ltda, Pasto
The First Affiliated Hospital of Hainan Medical University, Haikou
Sichuan Cancer Hospital, Chengdu
Fundacion Cardiovascular de Colombia, Bucaramanga
Institutul Regional de Oncologie Iasi, Iași
The First Affiliated Hospital of Xi an Jiaotong University, Xi'an
Lanzhou University Second Hospital, Lanzhou
Gansu Wuwei Tumour Hospital, Wuwei
Ovidius Clinical Hospital, Ovidiu
Meir Medical Center, Kfar Saba
James Lind Centro de Investigacion del Cancer, Temuco
Clinica CIDO, Temuco
Centro de Estudios Clinicos SAGA Spa, Santiago
Centro de Estudios Clinicos e Investigaciones Medicas CeCim, Santiago
Assuta Medical Center, Jerusalem
Hadassah Ein-Kerem Medical Center, Jerusalem
Instituto Alexander Fleming, CABA
Hospital Universitario Fundacion Favaloro, Ciudad Autonoma de Buenos Aires
Hospital Privado Universitario de Cordoba, Córdoba
Hospital Provincial del Centenario, Rosario
Instituto Argentino de Diagnostico y Tratamiento IADT, Buenos Aires
Hospital Britanico de Buenos Aires, Buenos Aires
Núcleo de Oncologia da Bahia, Salvador
Centro de Oncologia Mackenzie, Curitiba
Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre
Clinica de Oncologia Reichow, Blumenau
Centro de Pesquisa e Ensino em Oncologia de Santa Catarina, Florianópolis
Instituto de Ensino e Pesquisa Sao Lucas Iep Sao Lucas, Santo André
Instituto Nacional de Cancer, Rio de Janeiro
Hospital Nove de Julho - dasa, São Paulo
Instituto Brasileiro de Controle do Cancer Ibcc, São Paulo
Cross Cancer Institute, Edmonton
The Ottawa Hospital Cancer Centre, Ottawa
Sunnybrook Research Institute Sunnybrook Health Sciences Centre, Toronto
Jewish General Hospital, Montreal
Fourth Hospital of Hebei Medical University, Shijiazhuang
Changzhi Peoples Hospital, Changzhi
Shanxi Province Cancer Hospital, Taiyuan
Institucion Prestadora de Servicios de Salud Sociedad Médica Rionegro SA Somer SA, Rionegro
Masarykuv onkologicky ustav, Brno
Fakultni nemocnice Hradec Kralove, Hradec Králové
Fakultni nemocnice Olomouc, Olomouc
Vseobecna fakultni nemocnice v Praze, Prague
Fakultni Thomayerova nemocnice, Prague
St Vincents University Hospital, Dublin
Azienda Ospedaliero Universitaria di Cagliari Policlinico Duilio Casula, Monserrato CA
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma
Azienda Ospedaliera San Giovanni Addolorata, Roma
Aichi Cancer Center, Nagoya
Nagoya University Hospital, Nagoya
Chiba Cancer Center, Chiba
National Cancer Center Hospital East, Kashiwa-shi
National Hospital Organization Shikoku Cancer Center, Matsuyama
National Hospital Organization Kyushu Cancer Center, Fukuoka
Gifu University Hospital, Gifu
Hokkaido University Hospital, Sapporo
Hyogo Cancer Center, Akashi-shi
Kobe City Medical Center General Hospital, Kobe
Ishikawa Prefectural Central Hospital, Kanazawa
Kagawa University Hospital, Kita-gun
Yokohama City University Medical Center, Yokohama
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center, Yokohama
Kyoto University Hospital, Kyoto
Niigata Cancer Center Hospital, Niigata
Kansai Medical University Hospital, Hirakata-shi
Osaka International Cancer Institute, Osaka
Kindai University Hospital, Osakasayama-shi
Osaka University Hospital, Suita-shi
Saitama Cancer Center, Kitaadachi-gun
Shizuoka Cancer Center, Sunto-gun
The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku
Keio University Hospital, Shinjuku-ku
Nacionalinis vezio institutas, Vilnius
Vilnius University Hospital Santaros Clinic Public Institution, Vilnius
Trials In Medicine SC, México
Oslo University Hospital, Oslo
Centro Medico Monte Carmelo, Arequipa
Centrum Onkologii im prof Franciszka Lukaszczyka, Bydgoszcz
Szpitale Pomorskie Spzoo, Gdynia
Biokinetica SA, Józefów
Szpital Wojewodzki imienia Mikolaja Kopernika w Koszalinie, Koszalin
Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji, Olsztyn
SPZOZ Opolskie Centrum Onkologii imienia prof Tadeusza Koszarowskiego w Opolu, Opole
Wielkopolskie Centrum Onkologii imienia Marii Sklodowskiej-Curie, Poznan
Wojewodzki Szpital im Sw Ojca Pio w Przemyslu, Przemyśl
Kliniki Neuroradiochirurgii Spzoo Radom Centr Onkolo im Bohater Radomsk Czerwca -76 Szpital Specjal, Radom
Unidade Local de Saude de Coimbra, EPE, Coimbra
Unidade Local de Saude do Alto Ave, EPE, Guimarães
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria, Lisbon
Unidade Local de Saude de Santo Antonio, EPE - Hospital de Santo Antonio, Porto
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE, Porto
Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao, Porto
Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao Sebastiao, Santa Maria da Feira
Institutul Clinic Fundeni, Bucharest
Institutul Oncologic Prof Dr Alexandru Trestioreanu Bucuresti, Bucharest
Steve Biko Academic Hospital, Pretoria
Korea University Anam Hospital, Seoul
Seoul National University Hospital, Seoul
Kangbuk Samsung Hospital, Seoul
Severance Hospital Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea Seoul St Marys Hospital, Seoul
Korea University Guro Hospital, Seoul
Hospital Universitario de Burgos, Burgos
Hospital Clinic i Provincial de Barcelona, Barcelona
Hospital de la Santa Creu i Sant Pau, Barcelona
Corporacio Sanitaria Parc Tauli, Sabadell
Sahlgrenska Universitetssjukhuset, Gothenburg
Karolinska Universitetssjukhuset Huddinge, Stockholm
Norrlands Universitetssjukhus, Umeå
Baskent Universitesi Adana Doktor Turgut Noyan Uygulama ve Arastirma Merkezi, Adana
Doktor Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi, Ankara
Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara
Memorial Ankara Hastanesi, Ankara
Ankara Bilkent Sehir Hastanesi, Ankara
Antalya Egitim ve Arastirma Hastanesi, Antalya
Lead Sponsor
Zai Lab (China only)
UNKNOWN
Amgen
INDUSTRY