A Randomized, Open-label, Multi-center, Phase III Study of Orelabrutinib in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) vs. R-CHOP Alone in Patients With Treatment-naїve Mantle Cell Lymphoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

356

Participants

Timeline

Start Date

December 22, 2021

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2027

Conditions
Treatment-naїve Mantle Cell Lymphoma
Interventions
DRUG

Orelabrutinib and R-CHOP

Orelabrutinib in Combinaion with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP)

DRUG

R-CHOP

Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP)

Trial Locations (22)

50011

NOT_YET_RECRUITING

The Fourth Hospital of Hebei Medical University, Shijiazhuang

100143

RECRUITING

Beijing Cancer Hospital, Beijing

110001

NOT_YET_RECRUITING

The First Hospital of China Medical University, Shenyang

130021

NOT_YET_RECRUITING

The First Hospital of Jilin University, Changchun

210029

NOT_YET_RECRUITING

Jiangsu Province Hospital, Nanjing

215006

NOT_YET_RECRUITING

The First Affiliated Hospital of Soochow University, Suzhou

230009

NOT_YET_RECRUITING

Anhui Province Cancer Hospital, Hefei

250021

NOT_YET_RECRUITING

Shandong Provincial Hospital, Jinan

300052

NOT_YET_RECRUITING

Hospital of Hematology, Chinese Academy of Medical Sciences, Tianjin

300060

NOT_YET_RECRUITING

Tianjin Cancer Hospital, Tianjin

310003

NOT_YET_RECRUITING

he First Affiliated Hospital of Zhengjiang University, Hangzhou

310022

NOT_YET_RECRUITING

Zhejiang Cancer Hospital, Hangzhou

361003

NOT_YET_RECRUITING

The First Affiliated Hospital of Xiamen University, Xiamen

410013

NOT_YET_RECRUITING

Tumor in Hunan Province, Hunan

430022

NOT_YET_RECRUITING

Wuhan Union Hospital, Wuhan

450008

NOT_YET_RECRUITING

Henan Tumor Hospital, Zhengzhou

450052

NOT_YET_RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510060

NOT_YET_RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

510180

NOT_YET_RECRUITING

Guangzhou First People's Hospital, Guangzhou

530021

NOT_YET_RECRUITING

The First Affiliated Hospital of Guangxi Medical University, Guangxi

610041

NOT_YET_RECRUITING

West China Hospital,Sichuan University, Chengdu

3300008

NOT_YET_RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

All Listed Sponsors
lead

Beijing InnoCare Pharma Tech Co., Ltd.

INDUSTRY