A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations

PHASE3RecruitingINTERVENTIONAL
Enrollment

450

Participants

Timeline

Start Date

October 28, 2021

Primary Completion Date

March 31, 2026

Study Completion Date

July 30, 2027

Conditions
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Interventions
DRUG

Trastuzumab Deruxtecan

Trastuzumab Deruxtecan administered by intravenous infusion

DRUG

Cisplatin

Investigator's choice of platinum chemotherapy (cisplatin) administered by intravenous infusion

DRUG

Carboplatin

Investigator's choice of platinum chemotherapy (carboplatin) administered by intravenous infusion

DRUG

Pembrolizumab

Pembrolizumab administered by intravenous infusion

DRUG

Pemetrexed

Pemetrexed administered by intravenous infusion

Trial Locations (163)

235

RECRUITING

Research Site, Taipei

333

RECRUITING

Research Site, Taoyuan District

833

RECRUITING

Research Site, Kaohsiung City

1210

RECRUITING

Research Site, Vienna

3000

RECRUITING

Research Site, Leuven

3500

RECRUITING

Research Site, Hasselt

4020

SUSPENDED

Research Site, Linz

6020

RECRUITING

Research Site, Innsbruck

6830

WITHDRAWN

Research Site, Rankweil

7100

RECRUITING

Research Site, Vejle

8036

WITHDRAWN

Research Site, Graz

9000

RECRUITING

Research Site, Ghent

10043

RECRUITING

Research Site, Orbassano

10048

RECRUITING

Research Site, Taipei

10065

RECRUITING

Research Site, New York

10408

RECRUITING

Research Site, Goyang-si

10604

RECRUITING

Research Site, Harrison

11553

RECRUITING

Research Site, Uniondale

11725

RECRUITING

Research Site, Commack

13620

SUSPENDED

Research Site, Gyeonggi-do

13915

RECRUITING

Research Site, Marseille

14165

WITHDRAWN

Research Site, Berlin-Zehlendorf

15232

RECRUITING

Research Site, Pittsburgh

20090

RECRUITING

Research Site, Monza

20141

RECRUITING

Research Site, Milan

20910

RECRUITING

Research Site, Silver Spring

21079

RECRUITING

Research Site, Dijon

22030

RECRUITING

Research Site, Edirne

26121

RECRUITING

Research Site, Oldenburg

28041

RECRUITING

Research Site, Madrid

28644

RECRUITING

Research Site, Cheongju-si

29730

RECRUITING

Research Site, Málaga

31059

RECRUITING

Research Site, Toulouse

33000

RECRUITING

Research Site, Bordeaux

34376

WITHDRAWN

Research Site, Immenhausen

34722

RECRUITING

Research Site, Kadıkoy/Istanbul

35033

WITHDRAWN

Research Site, Rennes

35040

RECRUITING

Research Site, Izmir

37126

RECRUITING

Research Site, Verona

40201

RECRUITING

Research Site, Taichung

40705

RECRUITING

Research Site, Taichung

43100

RECRUITING

Research Site, Parma

43201

WITHDRAWN

Research Site, Columbus

44093

RECRUITING

Research Site, Nantes

44280

WITHDRAWN

Research Site, Guadalajara Jalisco

44710

WITHDRAWN

Research Site, Canton

46026

RECRUITING

Research Site, Valencia

48109

RECRUITING

Research Site, Ann Arbor

50937

RECRUITING

Research Site, Cologne

53226

WITHDRAWN

Research Site, Milwaukee

54601

WITHDRAWN

Research Site, La Crosse

55131

RECRUITING

Research Site, Mainz

68020

RECRUITING

Research Site, Oaxaca City

68167

WITHDRAWN

Research Site, Mannheim

69126

WITHDRAWN

Research Site, Heidelberg

69373

RECRUITING

Research Site, Lyon

70403

RECRUITING

Research Site, Tainan City

72037

RECRUITING

Research Site, Le Mans

75246

RECRUITING

Research Site, Dallas

78200

WITHDRAWN

Research Site, San Luis Potosí City

80230

WITHDRAWN

Research Site, Culiacán

81377

RECRUITING

Research Site, München

88212

WITHDRAWN

Research Site, Ravensburg

90048

RECRUITING

Research Site, Los Angeles

90404

RECRUITING

Research Site, Santa Monica

90720

RECRUITING

Research Site, Los Alamitos

92868

RECRUITING

Research Site, Orange

94143

SUSPENDED

Research Site, San Francisco

94805

RECRUITING

Research Site, Villejuif

95403

WITHDRAWN

Research Site, Santa Rosa

97000

WITHDRAWN

Research Site, Mérida

97080

WITHDRAWN

Research Site, Würzburg

99089

WITHDRAWN

Research Site, Erfurt

99336

WITHDRAWN

Research Site, Kennewick

99508

RECRUITING

Research Site, Anchorage

100142

ACTIVE_NOT_RECRUITING

Research Site, Beijing

100730

ACTIVE_NOT_RECRUITING

Research Site, Beijing

110001

WITHDRAWN

Research Site, Shenyang

110016

ACTIVE_NOT_RECRUITING

Research Site, Shenyang

110085

RECRUITING

Research Site, Delhi

130021

ACTIVE_NOT_RECRUITING

Research Site, Changchun

150049

WITHDRAWN

Research Site, Harbin

200030

WITHDRAWN

Research Site, Shanghai

200032

RECRUITING

Research Site, Shanghai

210029

ACTIVE_NOT_RECRUITING

Research Site, Nanjing

225001

ACTIVE_NOT_RECRUITING

Research Site, Yangzhou

250117

RECRUITING

Research Site, Jinan

310020

RECRUITING

Research Site, Hangzhou

317000

RECRUITING

Research Site, Linhai

330006

ACTIVE_NOT_RECRUITING

Research Site, Nanchang

350014

RECRUITING

Research Site, Fuzhou

361003

COMPLETED

Research Site, Xiamen

400012

RECRUITING

Research Site, Mumbai

410008

ACTIVE_NOT_RECRUITING

Research Site, Changsha

410013

ACTIVE_NOT_RECRUITING

Research Site, Changsha

422002

RECRUITING

Research Site, Nashik

430022

ACTIVE_NOT_RECRUITING

Research Site, Wuhan

450008

WITHDRAWN

Research Site, Zhengzhou

500032

RECRUITING

Research Site, Hyderabad

510080

RECRUITING

Research Site, Guangzhou

518020

RECRUITING

Research Site, Shenzhen

560027

RECRUITING

Research Site, Bangalore

610041

RECRUITING

Research Site, Chengdu

650101

COMPLETED

Research Site, Kunming

650118

COMPLETED

Research Site, Kunming

710061

RECRUITING

Research Site, Xi'an

02118

WITHDRAWN

Research Site, Boston

02215

RECRUITING

Research Site, Boston

07920

RECRUITING

Research Site, Basking Ridge

08816

WITHDRAWN

Research Site, East Brunswick

07748

RECRUITING

Research Site, Middletown

07645

RECRUITING

Research Site, Montvale

08901

RECRUITING

Research Site, New Brunswick

14784-400

RECRUITING

Research Site, Barretos

89010-340

RECRUITING

Research Site, Blumenau

70200-730

RECRUITING

Research Site, Brasília

88034-000

RECRUITING

Research Site, Florianópolis

59075-740

RECRUITING

Research Site, Natal

40170-110

RECRUITING

Research Site, Salvador

01321-001

RECRUITING

Research Site, São Paulo

01327-001

RECRUITING

Research Site, São Paulo

38408-150

RECRUITING

Research Site, Uberlândia

V5Z 4E6

RECRUITING

Research Site, Vancouver

L6R 3J7

RECRUITING

Research Site, Brampton

M5G 1Z5

RECRUITING

Research Site, Toronto

H4A 3J1

RECRUITING

Research Site, Montreal

CN-325000

COMPLETED

Research Site, Wenzhou

01307

RECRUITING

Research Site, Dresden

HKG

RECRUITING

Research Site, Hong Kong

RECRUITING

Research Site, Jordan

Unknown

RECRUITING

Research Site, Hong Kong

00000

WITHDRAWN

Research Site, Shatin

00168

RECRUITING

Research Site, Roma

104-0045

ACTIVE_NOT_RECRUITING

Research Site, Chūōku

812-8582

ACTIVE_NOT_RECRUITING

Research Site, Fukuoka

277-8577

ACTIVE_NOT_RECRUITING

Research Site, Kashiwa

791-0280

RECRUITING

Research Site, Matsuyama

951-8566

ACTIVE_NOT_RECRUITING

Research Site, Niigata

700-8558

ACTIVE_NOT_RECRUITING

Research Site, Okayama

541-8567

ACTIVE_NOT_RECRUITING

Research Site, Osaka

589-8511

ACTIVE_NOT_RECRUITING

Research Site, Osakasayama-shi

060-8638

ACTIVE_NOT_RECRUITING

Research Site, Sapporo

980-0873

ACTIVE_NOT_RECRUITING

Research Site, Sendai

411-8777

ACTIVE_NOT_RECRUITING

Research Site, Sunto-gun

241-8515

ACTIVE_NOT_RECRUITING

Research Site, Yokohama

683-8504

ACTIVE_NOT_RECRUITING

Research Site, Yonago-shi

'14080

RECRUITING

Research Site, Mexico City

03810

RECRUITING

Research Site, Mexico City

1081 HV

RECRUITING

Research Site, Amsterdam

9700 RB

RECRUITING

Research Site, Groningen

2333 ZA

WITHDRAWN

Research Site, Leiden

6525 GA

RECRUITING

Research Site, Nijmegen

43-360

RECRUITING

Research Site, Bystra

80-952

RECRUITING

Research Site, Gdansk

10-357

COMPLETED

Research Site, Olsztyn

37-700

COMPLETED

Research Site, Przemyśl

02-781

RECRUITING

Research Site, Warsaw

03080

RECRUITING

Research Site, Seoul

05505

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

08908

RECRUITING

Research Site, L'Hospitalet de Llobregat

TAIWAN

RECRUITING

Research Site, Taipei

06680

RECRUITING

Research Site, Çankaya

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY