Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

NACompletedINTERVENTIONAL
Enrollment

219

Participants

Timeline

Start Date

December 16, 2021

Primary Completion Date

June 10, 2024

Study Completion Date

June 10, 2024

Conditions
End Stage Liver DIseaseLiver Failure
Interventions
DEVICE

VitaSmart Liver Machine Perfusion System

Following donor liver retrieval, preservation using static cold storage, and back table preparation in the transplant center operating room, the organ will be flushed with Belzer UW Machine Perfusion Solution (MPS) and perfused through the cannulated portal vein using cold, actively oxygenated MPS that is circulated at low pressure for 90 minutes to 5 hours. After disconnection from the device, donor liver implantation and reperfusion will proceed in accordance with institutional care standards.

OTHER

Static cold storage

Donor liver retrieval and preservation using standard of care cold storage methods

Trial Locations (16)

10029

Mount Sinai Hospital, New York

32224

Mayo Clinic, Jacksonville

33331

Cleveland Clinic, Weston

37232

Vanderbilt University Medical Center, Nashville

44195

Cleveland Clinic, Cleveland

46202

Indiana University, Indianapolis

48202

Henry Ford Hospital, Detroit

53792

University of Wisconsin Madison, Madison

63110

Washington University St. Louis, St Louis

68198

Nebraska Medical Center, Omaha

70121

Ochsner Clinic Foundation, New Orleans

77030

Houston Methodist Hospital, Houston

92408

Loma Linda University Medical Center, San Bernardino

94143

University of California San Francisco, San Francisco

94305

Stanford University Medical Center, Stanford

01895

Lahey Hospital and Medical Center, Burlington

Sponsors
All Listed Sponsors
lead

Bridge to Life Ltd.

INDUSTRY