30
Participants
Start Date
December 1, 2021
Primary Completion Date
November 13, 2023
Study Completion Date
October 4, 2024
NG-641 in combination with Nivolumab
"NG-641 is a replication competent adenoviral vector producing a bispecific T cell activator (TAc) targeting fibroblast activation protein (FAP) plus immune enhancer genes CXCL9/CXCL10/IFNa2. This can lead to killing of tumor cells and stimulation of immunity against the tumor cells.~Nivolumab is a human monoclonal antibody that targets the PD-1 cluster of differentiation 279 cell surface membrane receptor."
Moffitt-Advent Health Clinical Research Unit, Celebration
University of Cincinnati Cancer Center, Cincinnati
UCLA Department of Medicine, Santa Monica
Providence Medical Foundation, Fullerton
The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool
Oxford University Hospitals NHS Foundation Trust, Oxford
Lead Sponsor
Collaborators (1)
Bristol-Myers Squibb
INDUSTRY
Akamis Bio
INDUSTRY