Study of NG-641 in Combination With Nivolumab in Metastatic or Advanced Epithelial Tumours

PHASE1CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

December 1, 2021

Primary Completion Date

November 13, 2023

Study Completion Date

October 4, 2024

Conditions
Metastatic CancerEpithelial Tumor
Interventions
BIOLOGICAL

NG-641 in combination with Nivolumab

"NG-641 is a replication competent adenoviral vector producing a bispecific T cell activator (TAc) targeting fibroblast activation protein (FAP) plus immune enhancer genes CXCL9/CXCL10/IFNa2. This can lead to killing of tumor cells and stimulation of immunity against the tumor cells.~Nivolumab is a human monoclonal antibody that targets the PD-1 cluster of differentiation 279 cell surface membrane receptor."

Trial Locations (6)

34747

Moffitt-Advent Health Clinical Research Unit, Celebration

45267

University of Cincinnati Cancer Center, Cincinnati

90404

UCLA Department of Medicine, Santa Monica

92835

Providence Medical Foundation, Fullerton

L7 8YA

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

OX3 7LE

Oxford University Hospitals NHS Foundation Trust, Oxford

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Akamis Bio

INDUSTRY

NCT05043714 - Study of NG-641 in Combination With Nivolumab in Metastatic or Advanced Epithelial Tumours | Biotech Hunter | Biotech Hunter