Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)

PHASE2RecruitingINTERVENTIONAL
Enrollment

3,800

Participants

Timeline

Start Date

September 30, 2021

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
COVID-19
Interventions
DRUG

Nirmatrelvir/ritonavir (e.g. PAXLOVID™)

Nirmatrelvir 300mg BD for 5/7 Ritonavir 100mg BD for 5/7

DRUG

Nitazoxanide

Nitazoxanide 1.5g BD 7/7

DRUG

Molnupiravir and nirmatrelvir/ritonavir (e.g. PAXLOVID™)

Molnupiravir 800mg BD for 5/7, Nirmatrelvir 300mg BD for 5/7, Ritonavir 100mg BD for 5/7

DRUG

Hydroxychloroquine

Hydroxychloroquine 400mg D0 BD and 400MG OD for a further 6/7

OTHER

No treatment

No treatment (except antipyretics- paracetamol)

DRUG

Monoclonal antibodies

Monoclonal antibodies: 300mg tixagevimab/ 300 mg cilgavimab given once on D0

DRUG

Fluoxetine

Fluoxetine 40mg OD for 7/7

DRUG

Molnupiravir

Molnupiravir 800mg BD for 5/7

DRUG

Sotrovimab

Sotrovimab 500mg given once on D0

DRUG

Ensitrelvir

Ensitrelvir 375mg OD D0 and 125mg OD for a further 4/7

DRUG

Monoclonal antibodies

Monoclonal antibodies: 600mg casirivimab/ 600mg imdevimab given once on D0

DRUG

Favipiravir

Favipiravir 1800mg BD D0 and 800mg BD for a further 6/7

DRUG

Ivermectin

Ivermectin 600micrograms/kg/day for 7/7.

DRUG

Remdesivir

Remdesivir 200mg D0 and 100mg for a further 4/7.

DRUG

Atilotrelvir/ritonavir

Atilotrelvir 150mg BD for 5/7 Ritonavir 100mg BD for 5/7

DRUG

Metformin

Metformin 500mg TDS 5/7

DRUG

Nirmatrelvir/ritonavir

Nirmatrelvir 300mg BD for 5/7 Ritonavir 50mg BD for 5/7

DRUG

Nirmatrelvir/ritonavir

Nirmatrelvir 150mg BD for 5/7 Ritonavir 50mg BD for 5/7

DRUG

Nirmatrelvir

Nirmatrelvir 300mg BD for 5/7

Trial Locations (7)

10300

TERMINATED

Vajira hospital, Bangkok

10400

RECRUITING

Faculty of Tropical Medicine, Mahidol University, Bangkok

10540

TERMINATED

Bangplee Hospital, Mueang Samut Prakan

Unknown

RECRUITING

Universidade Federal de Minas Gerais, Minas Gerais

RECRUITING

Sukraraj Tropical & Infectious Disease Hospital, Kathmandu

TERMINATED

The Aga Khan University Hospital, Karachi

01000

RECRUITING

Laos-Oxford-Mahosot Wellcome Trust Research Unit, Vientiane

All Listed Sponsors
lead

University of Oxford

OTHER