A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

May 12, 2022

Primary Completion Date

August 31, 2027

Study Completion Date

September 28, 2029

Conditions
Lupus Nephritis
Interventions
DRUG

Obinutuzumab

Obinutuzumab will be administered by IV infusion at a dose of 1000 mg on Day 1, Day 14, Week 24, Week 26 and Week 52.

DRUG

Placebo

Placebo matching obinutuzumab will be administered by IV on Day 1, Day 14, Week 24, Week 26 and Week 52.

DRUG

Mycophenolate Mofetil

Mycophenolate Mofetil (MMF) will be taken by home administration orally at a target dose of 1200 mg/m\^2/day to a maximum of 2.5g/day from baseline (Day 1) onwards.

DRUG

Acetaminophen/paracetamol

Acetaminophen 1000 mg will be administered as pre-medication prior to infusions.

DRUG

Diphenhydramine hydrochloride (HCl)

Diphenhydramine HCl 50 mg will be administered as pre-medication prior to infusions.

DRUG

Methylprednisolone

Methylprednisolone 80 mg IV will be administered as pre-medication prior to infusions.

DRUG

Prednisone

Oral prednisone or equivalent corticosteroid will be taken by home administration daily to a maximum dose of 60mg/day followed by a guided taper to 5mg/day or less by Week 24.

Trial Locations (42)

7500

RECRUITING

Panaroma Medical Center, Panorama

7700

WITHDRAWN

Red Cross War Memorial Children?s Hospital, Cape Town

7925

WITHDRAWN

Groote Schuur Hospital, Cape Town

11042

RECRUITING

Cohen Children's Medical Center of New York, Queens

16148

RECRUITING

IRCCS G. Gaslini, Genoa

19104

WITHDRAWN

Chldren?s Hospital of Philadelphia, Philadelphia

20122

RECRUITING

Clinica Pediatrica II De Marchi, Milan

28034

RECRUITING

Hospital Ramon y Cajal, Madrid

28046

RECRUITING

Hospital de La Paz, Madrid

30322

RECRUITING

Emory Children's Center, Atlanta

31000

RECRUITING

CHU de Toulouse - Hôpital des Enfants, Toulouse

44620

RECRUITING

CREA Hospital Mexico Americano, Guadalajara

45229

RECRUITING

Cincinnati Childrens Hospital, Cincinnati

46026

RECRUITING

Hospital Universitario la Fe: Servicio de Reumatologia Pediatrica, Valencia

46202

RECRUITING

Indiana University Health University Hospital, Indianapolis

64460

RECRUITING

Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey

71103

RECRUITING

Louisiana State University, Shreveport

75019

RECRUITING

Hôpital Robert Debré, Paris

75743

RECRUITING

Hop Necker Enfants Malades, Paris

79902

WITHDRAWN

Texas Arthritis Center, El Paso

80045

RECRUITING

Children's Hospital Colorado, Anchutz Medical Campus, Aurora

92354

RECRUITING

Loma Linda University health, Loma Linda

94158

RECRUITING

UCSF Benioff Childrens Hospital, San Francisco

94275

RECRUITING

CH de Bicêtre, Le Kremlin-Bicêtre

194100

WITHDRAWN

Saint-Petersburg State, St-peterburg

07601

RECRUITING

Hackensack University Medical Center, Hackensack

40150-150

RECRUITING

Ser Servicos Especializados Em Reumatologia, Salvador

13060-904

RECRUITING

Centro de Pesquisa São Lucas, Campinas

05403-000

RECRUITING

Hospital das Clinicas - FMUSP, São Paulo

04024-002

ACTIVE_NOT_RECRUITING

Universidade Federal de Sao Paulo - UNIFES, São Paulo

M5G 1X8

RECRUITING

The Hospital for Sick Children, Toronto

H3T 1C5

RECRUITING

Hospital Sainte-Justine, Montreal

00165

RECRUITING

Ospedale Pediatrico Bambino Gesu, Rome

06700

RECRUITING

Clinstile S.A de C.V., Mexico City

Unknown

ACTIVE_NOT_RECRUITING

Instituto de Ginecología y Reproducción, Lima

L27 Lima

ACTIVE_NOT_RECRUITING

Clinica El Golf, San Isidro

80-294

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

87-100

WITHDRAWN

Szpital Specjalistyczny dla Dzieci i Doroslych, Torun

08950

RECRUITING

Hospital Sant Joan De Deu, Esplugas de Llobregat

G51 4TF

WITHDRAWN

Royal Hospital For Children, Glasgow

L12 2AP

RECRUITING

Alder Hey Childrens Hospital, Liverpool

WC1N 3JH

RECRUITING

Great Ormond Street Hospital for Children, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY