A Study of AV-101 (Dry Powder Inhaled Imatinib) in Patients With Pulmonary Arterial Hypertension (PAH)

PHASE2/PHASE3TerminatedINTERVENTIONAL
Enrollment

202

Participants

Timeline

Start Date

December 2, 2021

Primary Completion Date

August 9, 2024

Study Completion Date

August 9, 2024

Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG

AV-101

AV-101 (imatinib) administered via dry powder inhalation

DRUG

Placebo

Placebo administered via dry powder inhalation

Trial Locations (128)

137

Azienda Ospedaliera Universitaria Policlinico Umberto I, Rome

1002

Pauls Stradins Clinical University Hospital, Riga

1070

Hopital Erasme - Cliniques Universitaires de Bruxelles, Brussels

1090

AKH - Medizinische Universitat Wien, Vienna

1134

Hospital Britanico de Buenos Aires, Buenos Aires

1307

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

1425

Nexo Salud Investigación Clínica, Buenos Aires

Cardiología Palermo, CABA

2050

Royal Prince Alfred Hospital, Camperdown

2138

Concord Repatriation General Hospital, Concord West

2145

Westmead Hospital, Westmead

2193

Center of Chest Disease Johannesburg, Johannesburg

2747

Nepean Hospital, Kingswood

3000

UZ Leuven, Leuven

3004

The Alfred Hospital, Melbourne

4032

The Prince Charles Hospital, Chermside

4575

Sunshine Coast University Hospital, Birtinya

5000

Royal Adelaide Hospital, Adelaide

5009

Insituto Medico DAMIC, Córdoba

6150

Fiona Stanley Hospital, Murdoch

8036

Hospital Clinic de Barcelona, Barcelona

10016

NYU Langone Seaport, New York

10676

University General Hospital Attikon, Athens

11215

New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn

14080

Instituto Nacional de Cardiologia Dr Ignacio Chavez Rivera, Mexico City

15213

UPMC Presbyterian Hospital, Pittsburgh

17674

Cardiosurgery Hospital, Kallithea

19104

Hospital of the University of Pennsylvania, Philadelphia

19107

Thomas Jefferson University, Philadelphia

20073

George Washington University Medical Faculty Associates, Inc., Washington D.C.

20123

Ospedale San Giuseppe - Fatebenefratelli, Milan

20900

Azienda Socio Sanitaria Territoriale di Monza, Monza

23507

Sentara Medical Group - Sentara Pulmonary & Critical Care Specialists, Norfolk

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

27710

Duke University Medical Center - Duke South Clinic, Durham

28014

Hospital 12 de Octubre, Madrid

28046

Universidad Autonoma de Madrid, Madrid

29071

Hospital Universitario Virgen de la Victoria, Málaga

30322

Emory University, Atlanta

32224

Mayo Clinic Florida, Jacksonville

32804

Orlando Heart Center, Orlando

34295

Hopital Arnaud de Villeneuve, Montpellier

34362

The Lady Davis Carmel Medical Center, Haifa

35010

Hosp. Universitario Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria

35292

Universitaetsklinikum Giessen und Marburg GmbH Standort Giessen, Giesen

37007

Hospital universtario de Salamanca, Salamanca

37232

Vanderbilt University Medical Center, Nashville

37919

Stat Care Pulmonary Consultants, PLLC, Knoxville

39003

Hosp. Universitario Marques de Valdecilla, Santander

40016

Chongqing Medical University - The First Affiliated Hospital, Chongqing

43210

The Ohio State University Wexner Medical Center, Columbus

44160

CICUM San Miguel, Guadalajara

45007

Hospital Universitario de Toledo, Toledo

45219

The Lindner Center for Research and Education, Cincinnati

45267

University of Cincinnati, Cincinnati

46202

Indiana University Health, Indianapolis

48109

University of Michigan, Ann Arbor

52242

University of Iowa Hospitals & Clinics, Iowa City

54637

AHEPA General Hospital of Thessaloniki, Thessaloniki

55455

University of Minnesota, Minneapolis

63110

Washington University School of Medicine, St Louis

64239

Tel Aviv Sourasky Medical Center, Tel Aviv

64460

Universidad Autonoma de Nuevo Leon, Hospital Universitario, Monterrey

64718

Unidad de Investigacion Clinica en Medicina S.C., Monterrey

66160

University of Kansas Medical Center, Kansas City

67091

Les Hôpitaux Universitaires de Strasbourg, Strasbourg

68198

University of Nebraska Medical Center- Hematology/Oncology Section, Omaha

69126

Universitaetsklinikum Heidelberg, Heidelberg

69677

Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel, Bron

71122

Azienda Ospedaliero Universitaria Ospedali Riuniti - Foggia, Foggia

75246

Baylor University Medical Center, Dallas

77030

Houston Methodist Hospital, Houston

80045

University of Colorado Denver, Aurora

80131

Azienda Ospedaliera Vincenzo Monaldi, Napoli

80206

National Jewish Health, Denver

81925

München Klinik Bogenhausen, München

85012

Arizona Pulmonary Specialists, Ltd., Phoenix

85724

University of Arizona, Department of Medicine, Tucson

87131

The Unviersity of New Mexico - UNM Hospitals, Albuquerque

90024

UCLA/David Geffen School of Medicine-Pulmonary and Criticial Care, Los Angeles

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90048

Cedars-Sinai Medical Center, Pulmonary & Critical Care, Los Angeles

90073

Dept of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles

90127

Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo

90509

LA Biomedical Research Institute Harbor, Torrance

91999

Hadassah University Hospital - Ein Kerem, Jerusalem

94143

University of California, San Francisco

94275

Groupement Hospitalier Sud - Hôpital Bicêtre, Le Kremlin-Bicêtre

Hôpital Nord - CHU Marseille, Marseille

95817

UC Davis Medical Center, Sacramento

97701

Bend Memorial Clinic, Oregon City

100730

Peking Union Medical College Hospital, Beijing

119074

National University Hospital, Singapore

200437

Shanghai Pulmonary Hospital, Shanghai

210009

Southeast University (SEU) - Zhongda Hospital, Nanjing

300052

Tianjin Medical University General Hospital, Tianjin

308433

Tan Tock Seng Hospital, Singapore

410011

Central South University - The Second Xiangya Hospital, Hunan

510000

Guangdong Provincial People's Hospital, Guangdong

650051

Yanan Hospital of Kunming City, Kunming

730000

Gansu Provincial People's Hospital, Lanzhou

8330024

Centro de Investigaciones Clinicas de la Universidad Catolica, Santiago

02111

Tufts Medical Center, Inc., Boston

C1039AAO

Sanatorio de la Trinidad Mitre, Buenos Aires

X5004FJE

Hospital Italiano de Cordoba, Córdoba

S300EOZ

Hospital Dr. Jose Maria Cullen, Santa Fe

90035-074

Santa Casa de Misericordia de Porto Alegre, Porto Alegre

05403

Heart Institute - University of Sao Paulo, São Paulo

T2N 1N4

The Governors of the University of Calgary, Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

N6A 5W9

London Health Science Centre, London

H3T 1E2

Jewish General Hospital, Montreal

128 21

Vseobecna fakultni nemocnice v Praze, Prague

1081 HV

Amsterdam UMC, Locatie VUMC, Amsterdam

31-202

Krakowski Szpital Specjalistyczny im. Jana Pawla II, Krakow

91-347

Bieganski Provincial Specialist Hospital, Lodz

61-848

Szpital Kliniczny Przemienienia Pańskiego UM im. Marcinkowskiego, Poznan

50-556

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego, Wroclaw

2805-267

Hospital Garcia de Orta, EPE, Almada

1649-035

Hospital Pulido Valente, Lisbon

4099-001

CHUPorto, Porto

00968

Cardiopulmonary Research Center, Guaynabo

08035

Hospital Universitari Vall d'Hebron, Barcelona

907 37

Norrlands Universitetssjukhus, Umeå

W12 0HS

Imperial College Healthcare NHS Trust, London

G81 4DY

Golden Jubilee National Hospital, Glasgow

SW3 6HP

Royal Brompton Hospital, London

NE7 7DN

The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle

Sponsors
All Listed Sponsors
lead

Aerovate Therapeutics

INDUSTRY

NCT05036135 - A Study of AV-101 (Dry Powder Inhaled Imatinib) in Patients With Pulmonary Arterial Hypertension (PAH) | Biotech Hunter | Biotech Hunter