The Treatment of Bioartificial Liver With hiHep Cells After Extensive Hepatectomy

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

September 5, 2021

Primary Completion Date

November 30, 2030

Study Completion Date

November 30, 2030

Conditions
Hepatoma Resectable
Interventions
BIOLOGICAL

hiHep bioartificial liver therapy

HiHep cell bioartificial liver treatment was performed 48-72 hours after extensive hepatectomy. Temporary hemodialysis tube for large vein (jugular vein or femoral vein) is indwelled before treatment. Before treatment, prepare hiHeps-BAL in a biological safety cabinet that meets clinical standards, connect the corresponding tubing to the Jianfan DX-10 blood purification machine, and prefill with heparin saline. Half an hour before treatment, the patient was pre-heparinized (heparin about 600iu) and dexamethasone to prevent allergic reactions. The patient enters the ICU, the monitor is connected to the corresponding pipeline, the arterial pump 120-160ml/min, the slurry pump 30-40ml/min, the circulating pump 75-100ml/min, the duration is 4-6h.

Trial Locations (1)

310000

RECRUITING

Department of General Surgery, Institute of Minimally Invasive Surgery, Sir Run Run Shaw Hospital, Hangzhou

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Hexaell Biotech Co., Ltd.

INDUSTRY

lead

Sir Run Run Shaw Hospital

OTHER