435
Participants
Start Date
September 14, 2021
Primary Completion Date
May 12, 2023
Study Completion Date
November 21, 2023
VX-121/TEZ/D-IVA
Fixed-dose combination tablets for oral administration.
ELX/TEZ/IVA
Fixed-dose combination tablets for oral administration.
IVA
Tablet for oral administration.
Placebo (matched to VX-121/TEZ/D-IVA)
Placebo matched to VX-121/TEZ/D-IVA for oral administration.
Placebo (matched to ELX/TEZ/IVA)
Placebo matched to ELX/TEZ/IVA for oral administration.
Placebo (matched to IVA)
Placebo matched to IVA for oral administration.
Columbia University Medical Center, New York
New York Medical College, Valhalla
Northwell Health- Long Island Jewish Medical Center, New Hyde Park
Albany Medical College, Albany
CF Therapeutics Development Center of Western New York, Buffalo
UPMC Children's Hospital of Pittsburgh, Pittsburgh
Children's Hospital of Philadelphia, Philadelphia
Inova Fairfax, Falls Church
University of Virginia Health System, Charlottesville
Wake Forest Baptist Health, Winston-Salem
Atrium Health Levine Children's Hospital, Charlotte
The Emory Clinic at Chantilly, Atlanta
Augusta University, Augusta
University of Florida, Shands Hospital, Gainesville
Central Florida Pulmonary Group, PA, Orlando
Nemours Children's Hospital, Orlando
Joe DiMaggio Cystic Fibrosis & Pulmonary Center, Hollywood
Johns Hopkins All Children's Hospital Outpatient Care Center, St. Petersburg
University of Alabama at Birmingham, Birmingham
Vanderbilt University Medical Center, Nashville
University of Tennessee Medical Center, Knoxville
Children's Foundation Research Center / Le Bonheur Children's Hospital, Memphis
University of Mississippi Medical Center, Jackson
Kosair Charities Pediatric Clinical Research Unit, Louisville
University of Kentucky, Lexington
Nationwide Children's Hospital, Columbus
ProMedica Toledo Hospital/Toledo Children's Hospital/Pediatric Pulmonary & Cystic Fibrosis Center, Toledo
Cleveland Clinic CF, Cleveland
Dayton Children's Hospital, Dayton
Indiana University, Indianapolis
Riley Hospital for Children at Indiana University Health, Indianapolis
Helen DeVos Children's Hospital CF Center, Grand Rapids
University of Wisconsin Hospital and Clinics, Madison
University of Minnesota, Minneapolis
Sanford Children's Speciality Clinic, Sioux Falls
Billings Clinic, Billings
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Northwestern Memorial Hospital, Chicago
Cardinal Glennon Children's Hospital - St. Louis University, St Louis
Washington University School of Medicine / St. Louis Children's Hospital, St Louis
The Children's Mercy Hospital, Kansas City
Childrens Hospital University of Missouri Health Sciences Center, Columbia
University of Kansas Medical Center, Kansas City
Nebraska Medical Center, Omaha
Tulane Medical Center, New Orleans
Arkansas Children's Hospital, Little Rock
Cook Children's Health Care System, Fort Worth
Texas Children's Hospital - Baylor College of Medicine, Houston
Driscoll Children's Hospital, Corpus Christi
Children's Hospital of Colorado, Aurora
National Jewish Health, Denver
St. Luke's Cystic Fibrosis Center of Idaho, Boise
University of Utah - Primary Children's Medical Center, Salt Lake City
Banner University of Arizona Medical Center, Tucson
Children's Hospital Los Angeles, Los Angeles
Miller Children's Hospital / Long Beach Memorial, Long Beach
University of California San Francisco, Lung Transplant Program, San Francisco
Kaiser Permanente, Oakland
University of California Davis Medical Center, Sacramento
Oregon Health & Science University, Portland
University of Washington Medical Center, Seattle
Massachusetts General Hospital Cystic Fibrosis Center Clinical Rsearch Center, Boston
Boston Children's Hospital, Boston
UMass Memorial Medical Center, Worcester
Michigan Medicine, Ann Arbor
Dartmouth Hitchcock, Manchester, Manchester
Morristown Medical Center, Morristown
The University of Texas Southwestern Medical Center, Dallas
Vermont Lung Center, Colchester
Royal Prince Alfred Hospital, Camperdown
The Prince Charles Hospital, Chermside
Alfred Hospital, Melbourne, VIC
Mater Adult Hospital, South Brisbane
Queensland Children's Hospital, South Brisbane
Westmead Hospital, Westmead
Klinika Detskych Infekcnich Nemoci, Brno
Fakultni nemocnice v Motole, Prague
Charite Paediatric Pulmonology Department, Berlin
St. Josef-Hospital, Bochum
Friedrich-Alexander University of Erlangen-Nuremberg, University Children's Hospital, Erlangen
Ruhrlandklinik Westdeutsches Lungenzentrum am Klinikum Essen, Essen
Universitatsklinikum Essen (AoR), Kinderklinik III, Abt. fur Pneumologie, Essen
Johann Wolfgang Goethe University, Frankfurt
Hannover Medical School, Hanover
Medizinische Hochschule Hannover, Hanover
Mukoviszidose-Zentrum am Universitätsklinikum Jena, Klinik für Kinder- und Jugendmedizin, Jena
Johannes Gutenberg-Universitaet, Mainz
Klinikum Innenstadt, University of Munich, München
Pneumologisches Studienzentrum Muenchen-West, München
Klinikum Westbrandenburg (CF), Potsdam
Universitätsklinikum Ulm, Klinik für Kinder- und Jugendmedizin (CF), Ulm
Universitätsklinikum Würzburg, Würzburg
National Koranyi Institute for TBC and Pulmonology, Budapest
Pulmonology Institute Torokbalint, Törökbálint
Cork University Hospital, Cork
Children's Health Ireland at Crumlin, Dublin
Children's Health Ireland at Tallaght, Dublin
Children's Health Ireland at Temple Street, Dublin
St. Vincent's University Hospital, Dublin
University Hospital Limerick (Adults), Limerick
University Hospital Limerick (Pediatrics), Limerick
Hadassah University Hospital Mount Scopus, Jerusalem
Schneider Children's Medical Center of Israel, Petach Tikvah
Sheba Medical Center - The Edmond and Lili Safra Children's Hospital, Tel Litwinsky
Greenlane Clinical Centre, Auckland
Starship Children's Hospital, Auckland
Canterbury Respiratory Research Group, Christchurch Hospital
Waikato Hospital, Hamilton
Hospital de Santa Maria, Lisbon
CHP - Hospital de Santo Antonio, Porto
Hospital Sao Joao, Porto
Hospital Saint Joan de Deu, Barcelona
Hospital Universitari Vall d Hebron, Barcelona
Hospital Infantil Universitario Nino Jesus, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario Ramon y Cajal, Madrid
Hospital Virgen de la Arrixaca, Murcia
Corporacio Sanitaria Parc Tauli - Sabadell Hospital Universitari, Sabadell
Hospital Universitario Virgen del Rocio, Seville
Hospital Universitario y Politecnico La Fe, Valencia
Sahlgrenska Universitetssjukhuset, Gothenburg
Lund University Skanes Universitetssjukhus, Malmo
Karolinska Universitetssjukhuset, Huddinge, Stockholm
Birmingham Heartlands Hospital, Birmingham
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol Royal Hospital, Bristol
Royal Papworth Hospital NHS Foundation Trust, Cambridge
Royal Hospital for Sick Children, Edinburgh
Western General Hospital, Edinburgh
Royal Devon and Exeter Hospital, Exeter
Clinical Research Facility, Queen Elizabeth University Hospital, Glasgow
St. James University Hospital, Leeds
Liverpool Heart and Chest Hospital, Liverpool
King's College Hospital, London
Royal Brompton Hospital, London
St. Bartholomew's Hospital, London
Wythenshawe Hospital, Manchester
Clinical Research Facility, Newcastle upon Tyne
All Wales Adult Cystic Fibrosis Centre, University Hospital Llandough, Penarth
Southampton General Hospital, Southampton
Vertex Pharmaceuticals Incorporated
INDUSTRY