70
Participants
Start Date
January 1, 2020
Primary Completion Date
December 1, 2022
Study Completion Date
December 30, 2022
radiofrequency ablation
All patients underwent biliary sphincterotomy. Cholangiogram was performed to confirm stricture location, length and diameter. The Habib Endo HPB (Hepatobiliary) probe (EMcision, HitchinHerts, UK) was then advanced over a wire at the level of the biliary stricture and ablation using ERBE generator set at 7-10 watts for a time period of 90-120 s was conducted. A 1- to 2-min resting period after energy delivery was allowed before moving the catheter along the length of the stricture to ablate the rest of the stricture. Plastic stent(s) were placed after RFA depending on the location of the malignant obstruction
Chemotherapy drug
Gemcitabine 1 000 mg/m2 intravenously on day 1，8; S-1 80 mg/m2 was taken orally twice for two weeks. The curative effect was evaluated comprehensively for each 2 cycles of chemotherapy
Hangzhou First People's Hospital, Hangzhou
Hangzhou Cancer Hospital
OTHER
Changhai Hospital
OTHER
Eastern Hepatobiliary Surgery Hospital
OTHER
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
OTHER
Xijing Hospital
OTHER
First People's Hospital of Hangzhou
OTHER