Combination Therapy for the Treatment of Diffuse Midline Gliomas

PHASE2RecruitingINTERVENTIONAL
Enrollment

360

Participants

Timeline

Start Date

October 20, 2021

Primary Completion Date

December 31, 2027

Study Completion Date

June 30, 2029

Conditions
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-MutantRecurrent Diffuse Intrinsic Pontine GliomaRecurrent Diffuse Midline Glioma, H3 K27M-MutantRecurrent WHO Grade III GliomaWHO Grade III Glioma
Interventions
DRUG

ONC201

Given orally (PO)

RADIATION

Radiation Therapy

Undergo radiation therapy

DRUG

Paxalisib

Given PO

Trial Locations (32)

2031

RECRUITING

Sydney Children's Hospital, Sydney

2152

RECRUITING

The Children's Hospital at Westmead, Westmead

2305

RECRUITING

John Hunter Children's Hospital, New Lambton Heights

3052

RECRUITING

The Royal Children's Hospital Melbourne, Melbourne

3168

RECRUITING

Monash Children's Hospital, Clayton

6009

RECRUITING

Perth Children's Hospital, Nedlands

10016

RECRUITING

New York University, New York

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

20010

RECRUITING

Children's National Hospital, Washington D.C.

21287

RECRUITING

Johns Hopkins University, Baltimore

27708

RECRUITING

Duke University, Durham

35233

RECRUITING

University of Alabama at Birmingham, Birmingham

43205

RECRUITING

Nationwide Children's Hospital, Columbus

46202

RECRUITING

Indiana University Riley Children's Hospital, Indianapolis

48109

RECRUITING

University of Michigan, Ann Arbor

55404

RECRUITING

Children's Hospital Minnesota, Minneapolis

60611

RECRUITING

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

63110

RECRUITING

Washington University in St. Louis, St Louis

84101

RECRUITING

University of Utah, Salt Lake City

90027

RECRUITING

Children's Hospital Los Angeles, Los Angeles

92123

RECRUITING

University of California, San Diego / Rady Children's Hospital, San Diego, San Diego

94143

RECRUITING

University of California, San Francisco, San Francisco

98101

RECRUITING

Seattle Children's Hospital, Seattle

9103102

RECRUITING

Shaare Zedek Medical Center, Jerusalem

02215-6024

RECRUITING

Dana-Farber Cancer Institute Harvard University, Boston

07601

RECRUITING

Hackensack Meridian Health, Hackensack

Unknown

RECRUITING

Queensland Children's Hospital, South Brisbane

RECRUITING

Women and Children's Hospital, Adelaide

RECRUITING

Sheba Medical Center, Tel Litwinsky

ACTIVE_NOT_RECRUITING

Princess Maxima Center, Utrecht

RECRUITING

Starship Children's Hospital, Auckland

RECRUITING

The University Children's Hospital in Zurich, Zurich

All Listed Sponsors
collaborator

The Chad-Tough Defeat DIPG Foundation

UNKNOWN

collaborator

Mithil Prasad Foundation

UNKNOWN

collaborator

Storm the Heavens Fund

UNKNOWN

collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

University of California, San Francisco

OTHER