Surgical Treatments for Postamputation Pain

NARecruitingINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

June 20, 2023

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2029

Conditions
Residual Limb PainAmputation NeuromaPhantom Limb PainPain, NeuropathicPain, Nerve
Interventions
PROCEDURE

Targeted Muscle Reinnervation (TMR)

Surgical procedure used to rewire injured proximal nerves to motor nerves directly innervating an otherwise redundant target muscle.

PROCEDURE

Regenerative Peripheral Nerve Interface (RPNI)

Surgical procedure where the the nerve is split into fascicles and wrapped in free muscle grafts.

PROCEDURE

Standard neuroma treatment, neuroma excision, and muscle burying

Surgical procedure where the neuroma is excised and the nerve stump is buried in an adjacent deep muscle.

Trial Locations (9)

40136

RECRUITING

Rizzoli Orthopedic Institute, Bologna

48109

NOT_YET_RECRUITING

University of Michigan Health System, Ann Arbor

60611

NOT_YET_RECRUITING

Northwestern Memorial Hospital, Chicago

02114

NOT_YET_RECRUITING

Massachusetts General Hospital, Boston

Unknown

NOT_YET_RECRUITING

Dandenong Hospital, Monash Health, Melbourne

NOT_YET_RECRUITING

Worker Hospital, Santiago

NOT_YET_RECRUITING

NHS Lothian, NHS Clyde & Greater Glasgow, and NHS Grampian, Edinburgh

AB T6G 2B7

NOT_YET_RECRUITING

University of Alberta Hospital, Edmonton

431 80

NOT_YET_RECRUITING

Sahlgrenska University Hospital, Mölndal

All Listed Sponsors
collaborator

Vastra Gotaland Region

OTHER_GOV

collaborator

Göteborg University

OTHER

collaborator

Istituto Ortopedico Rizzoli

OTHER

collaborator

Hospital del Trabajador de Santiago

OTHER

collaborator

NHS Lothian

OTHER_GOV

collaborator

NHS Greater Clyde and Glasgow

OTHER

collaborator

NHS Grampian

OTHER_GOV

collaborator

Northwestern Memorial Hospital

OTHER

collaborator

University of Michigan

OTHER

collaborator

Massachusetts General Hospital

OTHER

collaborator

Dandenong Hospital

UNKNOWN

collaborator

University of Alberta

OTHER

lead

Prometei Pain Rehabilitation Center

OTHER

NCT05009394 - Surgical Treatments for Postamputation Pain | Biotech Hunter | Biotech Hunter