Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)

PHASE3RecruitingINTERVENTIONAL
Enrollment

507

Participants

Timeline

Start Date

December 6, 2021

Primary Completion Date

November 30, 2027

Study Completion Date

November 30, 2030

Conditions
Colorectal Cancer
Interventions
DRUG

mFOLFOX6

Oxaliplatin: 85 mg/m², 2h IV infusion on d1 Folinic acid: 400 mg/m², 1-2 h IV infusion on d1 5-FU: (optional: 400 mg/m² bolus, 2-5 min IV infusion), 2400 mg/m², 46 h IV infusion on d1 Cycles are repeated on day 15. A total of up to 12 cycles are administered.

DRUG

mFOLFOXIRI

Oxaliplatin: 85 mg/m², 2h IV infusion on d1 Irinotecan: 150 mg/m², 90 min IV infusion on d1 Folinic acid: 400 mg/m², 1-2 h IV infusion on d1 5-FU: 2400 mg/m², 46 h IV infusion on d1 Cycles are repeated on day 15. A total of up to 12 cycles are administered.

DRUG

FOLFIRI

Folinic acid: 400mg/m², 1-2h IV Infusion on d1 5-FU: 2400 mg/m², 46 h IV infusion on d1 Irinotecan: 180 mg/m², 90-120 min IV infusion on d1 Cycles are repeated on day 15. A total of up to 12 cycles is administered.

DRUG

CAPOX

Capecitabine: 1000 mg/m², oral 1-0-1 on d1-14 Oxaliplatin: 130 mg/m², 3h IV infusion on d1 Cycles are repeated on day 22. A total of up to 8 cycles isadministered.

Trial Locations (79)

13353

RECRUITING

Charité Universitätsmedizin Berlin, Berlin

Unknown

RECRUITING

Klinikum St. Marien Amberg, Amberg

RECRUITING

Helios Klinikum Bad Saarow, Bad Saarow

RECRUITING

Klinikum Bayreuth, Bayreuth

RECRUITING

Helios Klinikum Emil von Behring, Berlin

RECRUITING

MVZ Onkologischer Schwerpunkt am Oskar-Helene-Heim, Berlin

RECRUITING

Vivantes Klinikum am Urban Berlin, Berlin

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Vivantes Klinikum Spandau Berlin, Berlin

RECRUITING

St. Josef-Hospital Bochum, Bochum

RECRUITING

Johanniterkrankenhaus Bonn, Bonn

WITHDRAWN

Diakonie-Krankenhaus Bremen, Bremen

RECRUITING

Klinikum Chemnitz, Chemnitz

RECRUITING

Kliniken der Satdt Köln, Cologne

RECRUITING

Klinikum Darmstadt, Darmstadt

RECRUITING

DONAUISAR Klinikum Deggendorf, Deggendorf

RECRUITING

Städtisches Klinikum Dessau, Dessau

RECRUITING

Onkologische-Gemeinschaftspraxis Dresden, Dresden

RECRUITING

Onkozentrum Dresden, Dresden

RECRUITING

Universitätsklinikum Düsseldorf, Düsseldorf

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Kliniken Essen-Mitte, Essen

RECRUITING

Universitätsklinikum Essen, Essen

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KHNW Frankfurt, Frankfurt

RECRUITING

Markus-Krankenhaus Frankfurt, Frankfurt

RECRUITING

Universitätsklinikum Frankfurt, Frankfurt

RECRUITING

Universitätsklinikum Freiburg, Freiburg im Breisgau

RECRUITING

Gemeinschaftspraxis internistische Onkologie Fürth, Fürth

RECRUITING

Niels-Stensen Kliniken Georgsmarienhütte, Georgsmarienhütte

RECRUITING

Praxis Hämatologie Onkologie Gießen, Giessen

RECRUITING

Universitätsmedizin Göttingen, Göttingen

RECRUITING

Universitätsklinikum Halle, Halle

RECRUITING

Universitätsklinikum Hamburg-Eppendorf, Hamburg

RECRUITING

Medizinische Hochschule Hannover, Hanover

RECRUITING

St. Anna Hospital Herne, Herne

RECRUITING

Universitätsklinikum des Saarlandes, Homburg

RECRUITING

Klinikum Ingolstadt GmbH, Ingolstadt

RECRUITING

Universitätsklinikum Jena, Jena

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Klinikum Landshut, Landshut

RECRUITING

VK&K Studien Landshut, Landshut

RECRUITING

Studienzentrum UnterEms Leer, Leer

RECRUITING

Universitätsklinikum Leipzig, Leipzig

RECRUITING

Klinikum Leverkusen, Leverkusen

RECRUITING

Klinikum Lippe, Lippe

RECRUITING

Klinikum Ludwigsburg, Ludwigsburg

RECRUITING

Klinikum Magdeburg, Magdeburg

RECRUITING

Universitätsmedizin Mainz, Mainz

RECRUITING

OnkoNet Marburg GmbH, Marburg

RECRUITING

Philipps-Universität Marburg, Marburg

RECRUITING

Johannes Wesling Klinikum Minden, Minden

WITHDRAWN

Kliniken Maria Hilf Mönchengladbach, Mönchengladbach

RECRUITING

Klinikum der Universität München, München

RECRUITING

Klinikum rechts der Isar TU München, München

RECRUITING

München Klinik Bogenhausen, München

RECRUITING

München Klinik Neuperlach, München

RECRUITING

Gemeinschaftspraxis Münster, Münster

RECRUITING

Universitätsklinikum Münster, Münster

RECRUITING

Friedrich-Ebert-Krankenhaus Neumünster, Neumünster

RECRUITING

Lukaskrankenhaus Neuss, Neuss

RECRUITING

Klinikum Nürnberg, Nuremberg

WITHDRAWN

Pi.Tri-Studien GmbH Offenburg, Offenburg

RECRUITING

Klinikum Passau, Passau

RECRUITING

Schwerpunktpraxis Penzberg, Penzberg

RECRUITING

Ernst von Bergmann Klinikum Potsdam, Potsdam

RECRUITING

Studienzentrum Onkologie Ravensburg, Ravensburg

RECRUITING

Krankenhaus Barmherzige Brüder Regensburg, Regensburg

RECRUITING

Universitätsklinikum Regensburg, Regensburg

RECRUITING

Kreiskliniken Reutlingen, Reutlingen

RECRUITING

Mathias Spital Rheine, Rheine

RECRUITING

RoMed Klinikum Rosenheim, Rosenheim

RECRUITING

Universitätsmedizin Rostock, Rostock

RECRUITING

DIAK Klinikum Schwäbisch Hall, Schwäbisch Hall

RECRUITING

Marienkrankenhaus Siegen, Siegen

RECRUITING

Klinikum Stuttgart, Stuttgart

WITHDRAWN

Marienhospital Stuttgart, Stuttgart

RECRUITING

Krankenhaus der Barmherzigen Brüder Trier, Trier

RECRUITING

Universitätsklinikum Ulm, Ulm

RECRUITING

Klinikum Wetzlar, Wetzlar

WITHDRAWN

Onkologisches Zentrum Wolfsburg-Helmstedt, Wolfsburg

RECRUITING

Petrus-Krankenhaus Wuppertal, Wuppertal

RECRUITING

Gemeinschaftspraxis Würzburg, Würzburg

Sponsors
All Listed Sponsors
collaborator

German Research Foundation

OTHER

collaborator

Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

OTHER

lead

Dominik Paul Modest

OTHER