Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC) and Other Solid Tumors, Receiving Intravenous (IV) Infusion of Azirkitug (ABBV-514) Alone or in Combination With Budigalimab or Bevacizumab

PHASE1RecruitingINTERVENTIONAL
Enrollment

512

Participants

Timeline

Start Date

November 1, 2021

Primary Completion Date

July 31, 2026

Study Completion Date

June 30, 2027

Conditions
Non-Small Cell Lung CancerHead and Neck Squamous Cell CarcinomaMicro Satellite Stable Colorectal CancerGastric/Esophageal CancerHigh-Grade Serous Ovarian CancerPancreatic CancerTriple Negative Breast Cancer
Interventions
DRUG

Azirkitug

Intravenous (IV) Infusion

DRUG

Budigalimab

Intravenous (IV) Infusion

DRUG

Bevacizumab

Intravenous (IV) Infusion

Trial Locations (34)

100

RECRUITING

National Taiwan University Hospital /ID# 251894, Taipei City

704

RECRUITING

National Cheng Kung University Hospital /ID# 252262, Tainan City

10408

RECRUITING

National Cancer Center /ID# 252290, Goyang-si

11031

RECRUITING

Taipei Medical University Hospital /ID# 252450, Taipei

11490

RECRUITING

Tri-Service General Hospital /ID# 252263, Taipei

13496

RECRUITING

CHA Bundang Medical Center /ID# 252291, Seongnam

22031

RECRUITING

Virginia Cancer Specialists - Fairfax /ID# 232592, Fairfax

23561

RECRUITING

Taipei Medical University Shuang Ho Hospital /ID# 252449, New Taipei City

28078

RECRUITING

Carolina BioOncology Institute /ID# 232597, Huntersville

46804

RECRUITING

Fort Wayne Medical Oncology and Hematology, Inc /ID# 232593, Fort Wayne

60607

RECRUITING

University of Illinois Hospital and Health Sciences System /ID# 251750, Chicago

68130

RECRUITING

Nebraska Cancer Specialists - Omaha - Wright Street /ID# 247399, Omaha

77030

RECRUITING

The University of Texas MD Anderson Cancer Center /ID# 270059, Houston

78229

RECRUITING

NEXT Oncology /ID# 243007, San Antonio

RECRUITING

South Texas Accelerated Research Therapeutics (START) /ID# 276268, San Antonio

84119

RECRUITING

Start Mountain Region /ID# 276270, West Valley City

91010

RECRUITING

City of Hope National Medical Center /ID# 276272, Duarte

91120

RECRUITING

Hadassah Medical Center-Hebrew University /ID# 252287, Jerusalem

3109601

RECRUITING

Rambam Health Care Campus /ID# 238333, Haifa

4941492

RECRUITING

Rabin Medical Center /ID# 250497, Petah Tikva

5265601

RECRUITING

The Chaim Sheba Medical Center /ID# 238332, Ramat Gan

46250-2042

RECRUITING

Community Health Network, Inc. /ID# 243011, Indianapolis

40241-2832

RECRUITING

Norton Cancer Institute /ID# 248903, Louisville

49546-7062

RECRUITING

START Midwest /ID# 248685, Grand Rapids

78705-1171

RECRUITING

NEXT Oncology Austin /ID# 243005, Austin

464-8681

RECRUITING

Aichi Cancer Center Hospital /ID# 250405, Nagoya

277-8577

RECRUITING

National Cancer Center Hospital East /ID# 238840, Kashiwa-shi

650-0017

RECRUITING

Kobe University Hospital /ID# 250409, Kobe

573-1191

RECRUITING

Kansai Medical University Hospital /ID# 276805, Hirakata-shi

411-8777

RECRUITING

Shizuoka Cancer Center /ID# 250408, Sunto-gun

104-0045

RECRUITING

National Cancer Center Hospital /ID# 238372, Chuo-ku

03722

RECRUITING

Yonsei University Health System Severance Hospital /ID# 252288, Seoul

05505

RECRUITING

Asan Medical Center /ID# 252289, Seoul

06591

RECRUITING

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 252867, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY