Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.

Series of three incremental bolus injections to observe α1-adrenoreceptor mediated vasoconstriction.

Standardized sympathetic stressor involving submersion of the hand in ice-cold water for 3-minutes, aiming to elicit endogenous neurotransmitter release and blood pressure increases.

During low altitude assessment, participants will be exposed to isocapnic hypoxia equivalent to 3,800m to assess responses to acute exposure.

During high altitude assessments, participants will breathe an oxygen concentration comparable to their end-tidal values at low altitude for the assessment of the influences of acclimatization.