Hypomemylating Agents Combination With eDC Therapy for Elderly Patients With Myelodysplastic Syndrome

PHASE1RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

July 1, 2021

Primary Completion Date

July 1, 2026

Study Completion Date

July 1, 2026

Conditions
Myelodysplastic SyndromesDendritic CellHypomethylating AgentsImmunotherapy
Interventions
BIOLOGICAL

DC vaccine

EDC cell therapy collection and administration process. Collection of PBMC for preparation of DC cells for patients with autologous DC cells, patient PBMC was collected 10-16 weeks before administration for the preparation and large-scale culture of DC cells. For the patients with matched DC cells, a small amount of peripheral blood was taken for HLA typing 4 weeks before administration, and then the matched DC cells were cultured on a large scale.

Trial Locations (1)

100071

RECRUITING

Department of hematology, Beijing

All Listed Sponsors
lead

Affiliated Hospital to Academy of Military Medical Sciences

OTHER