Repurposed Drugs to Improve Haematological Responses in Myelodysplastic Syndromes

PHASE2RecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

December 21, 2021

Primary Completion Date

January 31, 2025

Study Completion Date

June 30, 2025

Conditions
Myelodysplastic Syndromes (MDS)
Interventions
DRUG

Sodium Valproate, Bezafibrate, Medroxyprogesterone

Sodium valproate tablet 1 x 500mg bd, (starting 1 x 200mg bd) Bezafibrate standard release tablet 2 x 200mg tds, (starting 1 x 200mg tds) Medroxyprogesterone acetate tablet 1 x 400mg bd (starting 1 x 400mg od)

DRUG

Danazol

Danazol 1 x 200mg capsules tds, (starting 1 x 200mg od)

Trial Locations (19)

B9 5SS

RECRUITING

Heartlands Hospital, Birmingham

TR1 3LJ

RECRUITING

Royal Cornwall Hospital NHS Trust, Truro

BH15 2JB

RECRUITING

University Hospitals Dorset NHS Foundation Trust, Poole

DY1 2HQ

RECRUITING

Russells Hall Hospital, Dudley

NW1 2PG

RECRUITING

University College London Hospitals NHS Foundation Trust, London

SE5 9RS

RECRUITING

King's College Hospital NHS Foundation Trust, London

CM1 7ET

RECRUITING

Broomfield Hospital, Chelmsford

CO4 5JL

RECRUITING

Colchester General Hospital, Colchester

RG24 9NA

RECRUITING

Basingstoke and North Hampshire Hospital,, Basingstoke

SO22 5DG

RECRUITING

Royal Hampshire County Hospital, Hampshire Hospitals NHS Foundation Trust, Winchester

CT1 3NG

RECRUITING

East Kent Hospitals University Foundation Trust, Canterbury

NR31 6LA

RECRUITING

James Paget University Hospitals NHS Foundation Trust, Gorleston-on-Sea

NG5 1PB

RECRUITING

Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham

AB15 6RE

RECRUITING

Grampian Health Board, Aberdeen

B75 7RR

RECRUITING

Good Hope Hospital, Birmingham

HU3 2JZ

RECRUITING

Hull University Teaching Hospitals, Hull

LE1 5WW

RECRUITING

Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester

TS4 3BW

RECRUITING

James Cook University Hospital, South Tees Hospitals NHS Foundation Trust, Middlesbrough

NP18 3XQ

RECRUITING

Royal Gwent Hospital, Aneurin Bevan University Health Board, Newport

All Listed Sponsors
collaborator

Blood Cancer UK

UNKNOWN

collaborator

Dudley Group NHS Foundation Trust

OTHER

collaborator

University of Birmingham

OTHER

collaborator

University of Manchester

OTHER

collaborator

King's College Hospital NHS Trust

OTHER

lead

Prof. Janet Dunn

OTHER