(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

PHASE2RecruitingINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

November 9, 2021

Primary Completion Date

September 30, 2025

Study Completion Date

July 31, 2026

Conditions
Advanced Systemic Mastocytosis (AdvSM)SM With an Associated Hematologic Neoplasm (SM-AHN)Mast Cell Leukemia (MCL)Aggressive Systemic Mastocytosis (ASM)
Interventions
DRUG

bezuclastinib

Bezuclastinib is administered as tablets to be taken orally, continuously in 28-day cycles.

Trial Locations (42)

1090

ACTIVE_NOT_RECRUITING

AKH Wien, Universitatsklinikum, Vienna

2747

RECRUITING

Nepean Hospital, Kingswood

3051

RECRUITING

Peter MacCallum Cancer Centre, Melbourne N.

4000

ACTIVE_NOT_RECRUITING

CHU de Liege, Liège

4031

RECRUITING

Universitätsspital Basel, Basel

4215

RECRUITING

Gold Coast University Hospital, Southport

9713

ACTIVE_NOT_RECRUITING

University Medical Center Groningen, Groningen

10032

WITHDRAWN

Columbia University Irving Medical Center, New York

23562

ACTIVE_NOT_RECRUITING

UKSH Campus Lubeck, Lübeck

28034

ACTIVE_NOT_RECRUITING

Hospital Universitario Ramón y Cajal, Madrid

29425

RECRUITING

MUSC Health University Medical Center, Charleston

30322

RECRUITING

Winship Cancer Institute - Emory University, Atlanta

31300

ACTIVE_NOT_RECRUITING

Centre Hospitalier Universitaire (CHU) de Toulouse, Toulouse

33016

WITHDRAWN

Galiz Research, Hialeah

35233

ACTIVE_NOT_RECRUITING

University of Alabama at Birmingham (UAB) Hospital, Birmingham

37124

ACTIVE_NOT_RECRUITING

Azienda Ospidaleira Universitaria Integrata Verona, Verona

40138

ACTIVE_NOT_RECRUITING

IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna

44106

ACTIVE_NOT_RECRUITING

Cleveland Clinic Taussig Cancer Center, Cleveland

50134

ACTIVE_NOT_RECRUITING

Azienda Ospedaliero Universitaria Careggi, Florence

52074

ACTIVE_NOT_RECRUITING

University Hospital Aachen, Aachen

60612

WITHDRAWN

Rush University Medical Center, Chicago

68167

ACTIVE_NOT_RECRUITING

Universitätsklinikum Mannheim, Mannheim

75015

ACTIVE_NOT_RECRUITING

Necker-Enfants Malades Hospital, Paris

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

79104

ACTIVE_NOT_RECRUITING

Universitätsklinikum Freiburg, Freiburg im Breisgau

84112

RECRUITING

Huntsman Cancer Institute - University of Utah Health, Salt Lake City

84131

ACTIVE_NOT_RECRUITING

AOU San Giovanni di Dio e Ruggi dAragonia, Salerno

85054

RECRUITING

Mayo Clinic Arizona, Phoenix

86000

ACTIVE_NOT_RECRUITING

Centre Hospitalier Universitaire (CHU) de Poitiers, Poitiers

90095

RECRUITING

UCLA Medical Center, Los Angeles

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

94305

RECRUITING

Stanford Cancer Institute, Stanford

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

T6G 2G3

RECRUITING

University of Alberta Hospital, Edmonton

M5B 1W8

RECRUITING

St. Michael's Hospital - Unity Health Toronto, Toronto

0450

ACTIVE_NOT_RECRUITING

Oslo University Hospital, Oslo

20-400

ACTIVE_NOT_RECRUITING

Public University Hospital No. 1 in Lublin, Lublin

08740

ACTIVE_NOT_RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

08908

ACTIVE_NOT_RECRUITING

Institut Català d'Oncologia - Hospital Duran i Reynals, Barcelona

SE1 9RT

RECRUITING

Guy's Hospital - NHS Foundation Trust, London

LS9 7TF

RECRUITING

Leeds Teaching Hospitals NHS Trust, Leeds

NW1 2BU

RECRUITING

University College London Hospital - NHS Foundation Trust, London

Sponsors
All Listed Sponsors
lead

Cogent Biosciences, Inc.

INDUSTRY