Simufilam 100 mg for Mild-to-Moderate Alzheimer's Disease

PHASE3CompletedINTERVENTIONAL
Enrollment

804

Participants

Timeline

Start Date

November 3, 2021

Primary Completion Date

October 2, 2024

Study Completion Date

October 2, 2024

Conditions
Alzheimer Disease
Interventions
DRUG

Simufilam

Simufilam is a novel drug candidate designed to treat and slow the progression of AD. Simufilam binds with femtomolar affinity to an altered conformation of filamin A that is present in the brain of patients with AD and critical to the toxicity of Aβ42. In this study, simufilam will be given b.i.d. for 52 weeks at a dose of 100 mg.

DRUG

Placebo

Matching placebo given b.i.d. for 52 weeks.

Trial Locations (88)

2113

KaRa MINDS, Macquarie Park

3004

The Alfred Hospital, Melbourne

3050

Royal Melbourne Hospital, Parkville

3084

Austin Health, Heidelberg

3128

Eastern Health, Box Hill

3146

Delmont Private Hospital, Glen Iris

4029

The University of Queensland, Herston

4215

Impact Health Pty Ltd., Southport

8009

Australian Alzheimer's Research Foundation, Nedlands

10003

NY Neurology Associates, New York

11598

Five Town Neuroscience Research, Woodmere

12553

Mid Hudson Medical Research, New Windsor

14226

Dent Neurologic Institute, Amherst

14620

University of Rochester Medical Center - Alzheimer's Disease Care, Research and Education Program, Rochester

18507

Global Medical Institutes/Scranton Medical Institute - Moosic Division, Moosic

19355

Brian Abaluck, LLC, Malvern

22031

Re:Cognition Health, Fairfax

27410

Triad Clinical Trials, LLC, Greensboro

28105

Alzheimer's Memory Center, Matthew

29485

Palmetto Clinical Research, Summerville

32117

Arrow Clinical Trials, Daytona Beach

32127

Progressive Medical Research, Port Orange

32162

Charter Research, Lady Lake

32256

CNS Healthcare - Jacksonville, Jacksonville

32703

Topaz Clinical Research, Apopka

32751

ClinCloud, Maitland

32803

Charter Research, Orlando

32807

Combined Research Orlando Phase I-IV, Orlando

32952

Merritt Island Medical Research, LLC, Merritt Island

33009

Velocity Clinical Research, Hallandale Beach, Hallandale

33016

Galiz Research, Hialeah

33024

Infinity Clinical Research - Sunrise, Hollywood

33125

Central Miami Medical Institute (GMI), Miami

33140

Quantam Clinical Trials, Miami Beach

33165

New Horizon Research Center, Miami

33166

South Florida Research Phase I-IV INC, Miami Springs

33186

Luminous Clinical Research, Miami

33319

Segal Trials - West Broward Outpatient Site, Lauderhill

33407

Premier Research Institute at Palm Beach Neurology, West Palm Beach

33428

Neurology Offices of South Florida, Boca Raton

33437

Boynton Beach Medical Research Institute (GMI), Boynton Beach

33603

Clinical Research of Brandon, LLC (Tampa), Tampa

33613

Stedman Clinical Trials, Tampa

33912

Neuropsychiatric Research Center of Southwest Florida, Fort Myers

34470

Renstar Medical Research, Ocala

34652

Suncoast Clinical Research, Inc., New Port Richey

34711

K2 Medical Research - Clermont, Clermont

44122

Insight Clinical Trials LLC, Beachwood

44718

NeuroScience Research Center, LLC, Canton

45459

Dayton Center for Neurological Disorders, Centerville

60190

Northwestern Medicine Central DuPage Hospital, Winfield

63005

Clinical Research Professionals, Chesterfield

67214

Ascension Via Christi Research, Wichita

68046

CCT Research - Papillion Research Center, Papillion

71301

Neuro Medical Clinic of Central Louisiana, LLC, Alexandria

75206

Texas Neurology, PA, Dallas

75231

Baylor Scott & White Research Institute, Dallas

76309

Grayline Research Center, Wichita Falls

77450

Mt. Olympus Medical Research, LLC, Katy

78731

FutureSearch Trials of Neurology, Austin

78757

Senior Adults Specialty Research, Inc, Austin

80210

Colorado Neurological Research Center, PC, Denver

81621

Mountain Neurological Research Center, Basalt

83642

Velocity Clinical Research, Boise, Meridian

85004

Xenoscience, Inc., Phoenix

85286

MDFirst Research, Chandler

85297

CCT Research - Gilbert Neurology Partners, Gilbert

87109

Albuquerque Neuroscience, Inc, Albuquerque

92251

Sun Valley Research Center, Inc., Imperial

92324

Axiom Research, LLC, Colton

92503

Artemis Institute for Clinical Research, Riverside

92626

ATP Clinical Research, Inc., Costa Mesa

92653

Senior Clinical Trials, Laguna Hills

92705

Syrentis Clinical Research, Santa Ana

92805

Advanced Research Center, Inc, Anaheim

97210

Summit Research Network, LLC, Portland

98104

Memory and Brain Wellness Center at Harborview, Seattle

06416

CT Clinical Research, Cromwell

02747

Boston Neuro Research Center, North Dartmouth

07764

Advanced Clinical Institute, Inc, West Long Branch

11040-1433

Parker Jewish Institute for Health Care & Rehabilitation, New Hyde Park

02914

Rhode Island Mood & Memory Research Institute, East Providence

05701

Green Mountain Research Institute, Inc., Rutland

N6A 5R9

LMC Clinical Research - London, London

N7T 4X3

Bluewater Clinical Research Group Inc, Sarnia

J1J 2G2

Q & T Research, Sherbrooke

J1L0H8

Diex Research Sherbrooke Inc., Sherbrooke

G3K 2P8

Alpha Recherche Clinique, Québec

Sponsors
All Listed Sponsors
collaborator

Premier Research Group plc

UNKNOWN

lead

Cassava Sciences, Inc.

INDUSTRY