42
Participants
Start Date
March 23, 2022
Primary Completion Date
October 15, 2023
Study Completion Date
December 4, 2023
CPX-351
"Induction : patients will receive induction treatment with CPX-351 100 U/m2 on days 1, 3, and 5. Patients who fail to achieve CR/CRi after the induction cycle will be offered a second induction course of CPX-351 100 U/m2 on days 1 and 3, at the investigators' discretion. If CR/CRi is not achieved following the second induction cycle, patients will go off study~Consolidation : patients in CR/CRi after induction cycle will receive up to 2 course of consolidation therapy with CPX-351 65 U/m2 on days 1 and 3. CPX351 doses could be reduced to 65 U/m2 on day 1 in case of unacceptable toxicity following the previous course.~Allo-SCT : patients for whom an allo-SCT is planned will receive a maximum of one consolidation cycle"
MARSEILLE - Institut Paoli-Calmettes, Marseille
CAEN - CHU Caen - IHBN, Caen
BREST - Hôpital Morvan, Brest
NIMES - CHU Caremeau, Nîmes
Toulouse - IUCT Oncopole - Service d'Hématologie, Toulouse
BORDEAUX - Hôpital Haut-Levêque, Pessac
MONTPELLIER - Hôpital Saint-Eloi - Hématologie Clinique, Montpellier
RENNES - Hôpital Pontchaillou - Hématologie, Rennes
TOURS - Hôpital Bretonneau, Tours
Grenoble - CHUGA - Hématologie Clinique, Grenoble
NANTES - Hôpital Hôtel Dieu - Hématologie Clinique, Nantes
ORLEANS - CHR - Hématologie, Orléans
ANGERS - CHU - Maladies du sang, Angers
REIMS - Hôpital Robert Debré - Hématologie Clinique, Reims
NANCY - CHU de Brabois, Vandœuvre-lès-Nancy
LILLE CHU - Hôpital Claude Huriez, Lille
Clermont-Ferrand - Chu Estaing, Clermont-Ferrand
BAYONNE - CH de la Côte Basque - Hématologie, Bayonne
Strasbourg - Icans, Strasbourg
LYON-Centre Léon Bérard, Lyon
LYON HCL - CH Lyon Sud, Pierre-Bénite
Paris St Antoine, Paris
Paris Saint Louis, Paris
AMIENS - CHU Amiens Picardie, Amiens
AVIGNON - Centre Hospitalier, Avignon
POITIERS - Hôpital La Milétrie - Hématologie Clinique, Poitiers
LIMOGES - CHU Dupuytren 1, Limoges
CLAMART - Hôpital d'Instruction des Armées de Percy, Clamart
AVICENNE - Centre de Recherche Clinique, Bobigny
CRETEIL - CHU Henri Mondor, Créteil
NICE - Centre Antoine Lacassagne, Nice
NICE - CHU - Hopital Archet 1, Nice
VERSAILLES - Hôpital André Mignot, Versailles
Institut Gustave Roussy, Villejuif
Acute Leukemia French Association
OTHER
French Intergroup of Myeloproliferative syndromes
UNKNOWN
French Innovative Leukemia Organisation
OTHER