A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

776

Participants

Timeline

Start Date

November 17, 2021

Primary Completion Date

July 10, 2023

Study Completion Date

September 30, 2026

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

Lazertinib

Lazertinib will be administered orally.

DRUG

Amivantamab

Amivantamab will be administered as an IV infusion.

DRUG

Pemetrexed

Pemetrexed will be administered as an IV infusion.

DRUG

Carboplatin

Carboplatin will be administered as an IV infusion.

Trial Locations (247)

100

National Taiwan University Hospital, Taipei

402

Chung Shan Medical University Hospital, Taichung

500

Changhua Christian Hospital, Changhua

704

National Cheng Kung University Hospital, Tainan City

807

Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City

1303

Multifunctional Hospital for Active Treatment 'Serdika', Sofia

1340

Clinique Saint Pierre, Ottignies

1407

Multiprofile Hospital for Active Treatment 'Tokuda Hospital Sofia', Sofia

1756

Specialized Hospital for Active Treatment in Oncology, Sofia

1797

UMHAT Sofia Med, Sofia

2650

UZA, Edegem

3000

UZ Leuven, Leuven

3500

Jessa Ziekenhuis - Campus Virga Jesse, Hasselt

4000

CHU Sart-Tilman, Liège

5000

Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica, Córdoba

6060

Grand Hopital De Charleroi Site Les Viviers, Charleroi

9000

UZ Gent, Ghent

10408

National Cancer Center, Gyeonggi-do

11200

Mount Miriam Cancer Hospital, Tanjung Bungah

13125

Evangelische Lungenklinik Berlin, Berlin

13496

CHA Bundang Medical Center, CHA University, Gyeonggi-do

13620

Seoul National University Bundang Hospital, Gyeonggi-do

13915

Hopital Nord, Marseille

14080

Instituto Nacional de Cancerologia, México

15006

Hosp Univ A Coruna, A Coruña

15232

University of Pittsburgh Medical Center, Pittsburgh

19044

Alliance Cancer Specialists, Horsham

20141

Istituto Europeo di Oncologia, Milan

21075

Asklepios Klinikum Harburg, Hamburg

22030

Trakya University Medical Faculty, Edirne

22031

Virginia Cancer Specialists, Fairfax

22908

University of Virginia, Charlottesville

23561

Taipei Medical University Shuang Ho Hospital, New Taipei City

24382

Blue Ridge Cancer Care, Wytheville

25100

Hospital Tengku Ampuan Afzan, Kuantan

28007

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28040

Hosp Univ Fund Jimenez Diaz, Madrid

28041

Hosp. Univ. 12 de Octubre, Madrid

28046

Hosp. Univ. La Paz, Madrid

28050

Hosp Univ Hm Sanchinarro, Madrid

28222

Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda

29010

Hosp Regional Univ de Malaga, Málaga

30599

Fakultni nemocnice Plzen, Pilsen

30607

University Cancer And Blood Center LLC, Athens

31008

Clinica Univ. de Navarra, Pamplona

33081

CRO IRCCS Istituto Nazionale Tumori, Aviano

33308

Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale

33604

CHU Bordeaux, Pessac

34098

Istanbul University Cerrahpasa Medical Faculty, Istanbul

34147

Bakirkoy Training and Research Hospital, Istanbul

34214

Medipol Mega University Hospital, Istanbul

34295

CHU de Montpellier - Arnaud de Villeneuve, Montpellier

34722

Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi, Istanbul

35016

Hosp. Univ. Insular de Gran Canaria, Las Palmas de Gran Canaria

35033

CHRU Hopital de Pontchaillou, Rennes

35575

Medical Point, Izmir

36608

Southern Cancer Center, PC, Mobile

37000

CHU Bretonneau, Tours

CIMOVA, Morals Vargas Centro de Investigación SC, León

37134

Policlinico G.B.Rossi, Verona

38120

Baptist Cancer Center, Memphis

38700

CHU de Grenoble Hopital Albert Michallon, La Tronche

39216

University of Mississippi Medical Center, Jackson

40705

Taichung Veterans General Hospital, Taichung

41013

Hosp. Virgen Del Rocio, Seville

43126

Azienda Ospedaliero-Universitaria Di Parma, Parma

44280

Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara

44281

Meir Medical Center, Kfar Saba

44800

CHU Nantes, Sain-Herblain

45220

TriHealth Network, Cincinnati

45659

Oncologianova GmbH, Recklinghausen

46014

Hosp. Gral. Univ. Valencia, Valencia

46026

Hosp. Univ. I Politecni La Fe, Valencia

46050

Beacon Hospital Sdn Bhd, Petaling Jaya

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

47441

Bethanien Krankenhaus, Moers

47500

Subang Jaya Medical Centre, Subang Jaya

48121

Ospedale S. Maria Delle Croci, Ravenna

49100

Rabin Medical Center, Petah Tikva

52727

GyeongSang National University Hospital, Gyeongsangnam-do

53100

Oncologia Integral Satelite, Naucalpan

59000

CHR Hôpital Calmette, Lille

67091

Nouvel Hopital Civil - CHU Strasbourg, Strasbourg

68803

Nebraska Cancer Specialists, Grand Island

69126

Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg

69500

Hospices Civils de Lyon HCL, Bron

70300

Vitkovicka nemocnice a.s., Ostrava- Vitkovice

72000

Centre Hospitalier du Mans, Le Mans

74072

Onkologische Schwerpunktpraxis, Heilbronn

75005

Institut Curie, Paris

75181

Akademiska Sjukhuset, Uppsala

75230

Texas Oncology-Medical City Dallas, Dallas

75246

Texas Oncology Baylor Charles A Sammons Cancer Center, Dallas

75601

Texas Oncology - Northeast, Longview

76051

Texas Oncology, Grapevine

77030

Oncology Consultants Texas, Houston

80336

Klinikum der Universitaet Muenchen, München

80907

Rocky Mountain Cancer Centers, Colorado Springs

84101

Soroka University Medical Center, Beersheba

84918

Institut Sainte Catherine, Avignon

85711

Arizona Oncology Associates, Tucson

90048

Cedars Sinai Medical Center, Los Angeles

91010

City of Hope, Duarte

91031

Shaare Zedek Medical Center, Jerusalem

92868

University of California Irvine, Orange

93053

Universitaetsklinikum Regensburg, Regensburg

97213

Providence Portland Medical Center, Portland

97227

Kaiser Permanente Northwest, Portland

98373

NorthWest Medical Specialties, PLLC, Puyallup

98684

Compass Oncology, Vancouver

100021

Cancer Hospital, Chinese Academy of Medical Sciences, Beijing

100044

Peking University People s Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

100853

Chinese PLA General Hospital, Beijing

101199

Beijing Chest hospital, Capital medical university, Beijing

110085

Rajiv Gandhi Cancer Institute and Research Centre, New Delh

122001

Artemis Hospital, Gurugram

150000

Harbin medical university cancer hospital, Harbin

197022

Llc, Eurocityclinic, Saint Petersburg

200025

Ruijin Hospital Shanghai Jiao Tong University, Shanghai

200032

Fudan University Shanghai Cancer Center, Shanghai

261000

Weifang People's Hospital, Weifang

264000

Yantai Yuhuangding Hospital, Yantai

300052

Tianjin Medical University General Hospital, Tianjin

310000

Shanghai East Hospital, Shanghai

310009

Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou

The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou

310016

Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

317000

Taizhou Hospital of Zhejiang Province, Linhai

360000

City Clinical Hospital #1, Nal'chik

400000

Chongqing University Cancer Hospital, Chongqing

400012

Tata Memorial Hospital, Mumbai

400038

Southwest Hospital, Chongqing

400042

Daping Hospital Army Characteristic Medical Center, Yuzhong District

410013

Hunan Cancer hospital, Changsha

411013

Noble Hospital Pvt Ltd, Pune

411107

Bhaktivedanta Hospital & Research Institute, Thāne

422002

HCG Manavta Cancer Centre, Nashik

450008

Henan Cancer Hospital, Zhengzhou

510080

The First Affiliated Hospital Sun Yat sen University, Guangzhou

510120

Sun Yat-Sen Memorial Hospital Sun Yat-sen University, Guangzhou

516001

Huizhou Municipal Central Hospital, Huizhou

518055

Shenzhen university General Hospital, Shenzhen

518116

Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen

560027

Health Care Global Enterprises pvt Ltd, Bangalore

610041

Sichuan Cancer Hospital, Chengdu

West China Hospital Sichuan University, Chengdu

637503

Affiliated Hospital of North Sichuan Medical College, Nanchong

700160

Tata Medical Center, Kolkata

710061

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

999077

Queen Mary Hospital, Hong Kong

3109601

Rambam Health Corporation, Haifa

4200072

Instituto Portugues de Oncologia, Porto

5262100

Chaim Sheba Medical Center, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center, Tel Aviv

08816

Astera Cancer Care, East Brunswick

05401

University of Vermont Medical Center, Burlington

C1027AAP

CINME Centro de Investigaciones Metabolicas, Caba

C1122

IADT Instituto Argentino de Diagnostico y Tratamiento, CABA

C1414

Centro Medico Fleischer, CABA

C1431FWO

CEMIC (Centro de Educación Médica e Investigaciones Clínicas), CABA

X5016KEH

Hospital Privado Universitario De Cordoba, Córdoba

B7602CBM

Hospital Privado de la Comunidad, Mar del Plata

R8500ACE

Clínica Viedma, Viedma

30110-017

Cetus Oncologia, Belo Horizonte

80810 050

CIONC Centro Integrado de Oncologia de Curitiba, Curitiba

88020-210

Ynova Pesquisa Clinica, Florianópolis

35162 189

Fundacao Sao Francisco Xavier, Ipatinga

96020 080

UPCO Unidade de Pesquisa Clinica em Oncologia, Pelotas

90035-001

Associacao Hospitalar Moinhos de Vento, Porto Alegre

90160-093

Hospital Ernesto Dornelles, Porto Alegre

22250-905

Oncoclinicas Rio de Janeiro S A, Rio de Janeiro

22281 100

Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro

22775 001

Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro

40170 110

Nucleo de Oncologia da Bahia, Salvador

41253 190

Hospital Sao Rafael, Salvador

09060 650

CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia, Santo André

01323 900

Real e Benemerita Associacao Portuguesa de Beneficencia, São Paulo

01323-000

Hospital Paulistano, São Paulo

01327 001

Hospital Alemao Oswaldo Cruz, São Paulo

01409902

Hospital Nove de Julho, São Paulo

01509 900

Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo

04543-000

Onco Star SP Oncologia Ltda, São Paulo

18030-005

IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado, Sorocaba

38408-150

COT - Centro Oncologico do Triangulo S.A, Uberlândia

T2N 5G2

Arthur J E Child Comprehensive Cancer Centre, Calgary

V5Z 4E6

British Columbia Cancer Agency, Vancouver

H4A 3J1

McGill University Health Centre, Montreal

775 20

Fakultni nemocnice Olomouc - I.P.Pavlova 6, Olomouc

DK 2100

Rigshospitalet, Copenhagen

04357

POIS Sachsen GmbH iG, Leipzig

00144

Istituto Nazionale Tumori Regina Elena, Roma

377-0280

National Hospital Organization Shibukawa Medical Center, Gunma

673-8558

Hyogo Cancer Center, Hyōgo

241-8515

Kanagawa Cancer Center, Kanagawa

650 0047

Kobe City Medical Center General Hospital, Kobe

830-0011

Kurume University Hospital, Kurume

460-0001

National Hospital Organization Nagoya Medical Center, Nagoya

951-8566

Niigata Cancer Center Hospital, Niigata

541 8567

Osaka International Cancer Institute, Osaka

411 8777

Shizuoka Cancer Center, Shizuoka

113 8677

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo

135 8550

The Cancer Institute Hospital of JFCR, Tokyo

791-0295

Ehime University Hospital, Toon-shi

641 8510

Wakayama Medical University Hospital, Wakayama

740-8510

National Hospital Organization Iwakuni Clinical Center, Yamaguchi

755-0241

National Hospital Organization Yamaguchi Ube Medical Center, Yamaguchi

Unknown

University Malaya Medical Centre, Kuala Lumpur

03100

Health Pharma Professional Research, México

1081 HV

VUMC Amsterdam, Amsterdam

3844 DG

Ziekenhuis St Jansdal, Harderwijk

3015 GD

Erasmus MC, Rotterdam

85 796

Centrum Onkologii im Prof F Lukaszczyka, Bydgoszcz

80 952

Uniwersyteckie Centrum Kliniczne, Gdansk

81 519

Szpitale Pomorskie Sp z o o, Gdynia

10-357

Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie, Olsztyn

60 569

Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow, Poznan

60-693

Private Specialist Hospitals - MedPolonia, Poznan

02-781

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warsaw

1769-001

Uls Santa Maria - Hosp. Pulido Valente, Lisbon

2674 514

Uls Loures Odivelas - Hosp. Loures, Loures

4099-001

Uls Santo Antonio - Hosp. Santo Antonio, Porto

00917

Pan American Center for Oncology Trials LLC, Rio Piedras

02841

Korea University Anam Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea Seoul St Mary s Hospital, Seoul

08025

Hosp. de La Santa Creu I Sant Pau, Barcelona

08028

Hosp. Univ. Quiron Dexeus, Barcelona

08035

Hosp Univ Vall D Hebron, Barcelona

08036

Hosp Clinic de Barcelona, Barcelona

413 45

Sahlgrenska Universitetssjukhuset, Gothenburg

581 85

Linkoping University Hospital, Linköping

221 85

Skanes universitetssjukhus, Lund

901 85

Norrlands Universitetssjukhus, Umeå

01060

Adana City Hospital, Adana

06520

Memorial Ankara Hastanesi, Ankara

06560

Gazi University Hospital, Ankara

06800

Ankara Bilkent City Hospital, Ankara

CF14 2TL

Velindre Hospital, Cardiff

EH4 2XU

Edinburgh Cancer Centre Western General, Edinburgh

NW1 2PG

UCL Cancer Institute, London

SE1 9RT

Guys and St Thomas NHS Foundation Trust, London

SW3 6JJ

The Royal Marsden NHS Trust, London

M20 4BX

The Christie Nhs Foundation Trust, Manchester

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY