Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

343

Participants

Timeline

Start Date

September 9, 2021

Primary Completion Date

September 30, 2025

Study Completion Date

December 30, 2025

Conditions
Renal Cell Carcinoma
Interventions
DRUG

Tivozanib

Tivozanib will be administered orally.

DRUG

Nivolumab

Nivolumab will be administered via intravenous infusion.

Trial Locations (139)

1020

CHU Brugmann - Victor Horta, Brussels

1070

Institut Jules Bordet - Oncologie Médicale, Anderlecht

2170

Liverpool Hospital Cancer Therapy Centre, Liverpool

ZNA Jan Palfijn, Merksen

3220

Sunshine Hospital, Geelong

3500

Jessa Ziekenhuis - Campus Virga Jesse - Medische Oncologie, Hasselt

4101

Mater Misericordiae Limited, Brisbane

4102

Princess Alexandra Hospital, Woolloongabba

8003

Hospital Del Mar, Barcelona

8208

Hospital Universitari Parc Tau, Sabadell

8500

AZ Groeninge - Campus Kennedylaan, Kortrijk

9000

UZ Gent - Medische Oncologie, Ghent

10065

Memorial Sloan Kettering Cancer Center (MSKCC) - Memorial Hospital, New York

10604

Memorial Sloan Kettering Cancer Center - Westchester, East White Plains

11553

Memorial Sloan Kettering Cancer Center - Nassau, Uniondale

13273

Institut Paoli Calmettes - Hôpital de jour, Marseille

14080

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan

14263

Roswell - Roswell Park Cancer Institute - Medical Oncology, Buffalo

17007

ICO-Hospital Universitari de G, Girona

20141

European Institute of Oncology, Milan

20735

Maryland Oncology Hematology, Clinton

21201

University of Maryland Medical Center-Greenebaum Cancer Ctr, Baltimore

21287

John Hopkins Medicine - Hematology/oncology, Baltimore

27100

IRCCS Policlinico San Matteo, Pavia

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Clínico San Carlos, Madrid

28041

Hospital U. 12 Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

29210

UH Cleveland Medical Center, Columbia

30625

Medizinische Hochschule Hannover, Hanover

32005

C.H.U. de Orense, Ourense

33075

Hopital Saint-Andre - Service d'Oncologie Medicale, Bordeaux

33705

Florida Cancer Specialists & Research Institute (FCS) - Tampa Cancer Center Location, St. Petersburg

33901

Florida Cancer Specialists & Res Inst, Fort Myers

37044

Hopital Trousseau - medical oncology, Tours

37203

Tennessee Oncology, PLLC, Nashville

37232

Vanderbilt-Ingram Cancer Center, Nashville

37404

Chattanooga Oncology and Hematology Associates, Chattanooga

38043

CHU Michallon - Hopital Nord - Cancérologie Et Hématologie, Grenoble

40536

University of Kentucky UK Markey Cancer Center, Lexington

41009

Hospital Universitario Virgen, Seville

44805

ICO - Site Rene Gauducheau - Oncologie Medicale, Saint-Herblain

46009

Fundación Instituto Valenciano, Valencia

46026

Hospital Universitario Y Politécnico La Fe, Valencia

47014

IRST, Meldola (Fc)

48202

Henry Ford Hospital, Detroit

50134

AOUC Azienda Ospedaliero-Universitaria Careggi, Florence

52100

Ospedale S.Donato, AUSL 8 di Arezzo, Arezzo

54511

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

59000

Hôpital privé Le Bois, Lille

66013

P.O. Ss. Annunziata, Chieti Scalo

67200

Institut de cancérologie de Strasbourg Europe - ICANS, Strasbourg

68130

Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha

69120

Universitätsklinikum Heidelberg, Heidelberg

69373

Centre Leon Berard - departement d'oncologie medicale, Lyon

69495

Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud, Pierre-Bénite

70112

Tulane Cancer Center Clinic - Oncology, New Orleans

72000

Clinique Victor Hugo - Hematologie, Le Mans

75246

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

78240

US Oncology Texas Oncology (CCC of South Texas) - San Antonio Medical Center, San Antonio

78731

Texas Oncology - Central Austin Cancer Center, Austin

80131

"IRCCS Fondazione Giovanni Pas", Napoli

85925

CHD Vendee La Roche sur Yon - Gastro-Entérologie, La Roche-sur-Yon

86021

Centre Hospitalier de Poitiers, Poitiers

88100

Azienda Mater Domini, Catanzaro

91010

City of Hope Comprehensive Cancer Center, Duarte

92037

University of California San Diego, La Jolla

92151

Hopital Foch, Suresnes

92505

Kaiser Permanente Riverside Medical Center, Riverside

92868

Chao Family Comprehensive Cancer Center, UC Irvine, Irvine

94063

Leland Stanford Junior University, Redwood City

94805

Centre de Lutte Contre le Cancer (CLCC) - Gustave Roussy (Institut de Cancerologie Gustave-Roussy), Villejuif

98109

University Of Washington - Medical Center, Seattle

2520612

ACEREY Centro de Investigación Clínica Oncológica, Viña del Mar

8420383

Centro de Estudios Clinicos In, Santiago

Meditek Ltda., Santiago

80218-1237

US Oncology - Rocky Mountain Cancer Centers - Midtown, Denver

66205-2005

The University of Kansas Cancer Center, Westwood

02215

Dana-Farber Cancer Institute - Medicine, Boston

59102-6746

St. Vincent Frontier Cancer Center, Billings

07748-3052

Memorial Sloan Kettering Cancer Center - Monmouth - Oncology, Middletown

87131-0001

University of New Mexico - Comprehensive Cancer Center, Albuquerque

44195-0001

Cleveland Clinic, Cleveland

18103-6218

Lehigh Valley Physician Group, Allentown

15212-4756

Allegheny General Hospital (AGH), Pittsburgh

98405-5016

Northwest Medical Specialties PLLC, Tacoma

C1280AEB

Centro Oncológico Korben, Buenos Aires

R8500JYJ

Clínica Viedma, Viedma

S2000KZE

Centro Oncologico de Rosario, Rosario

T4000GTB

Centro para la Atención Integral del paciente Oncológico, San Miguel de Tucumán

90110-270

Centro Gaucho Integrado de Onc, Porto Alegre

88301-220

Clinica de Neoplasias Litoral, Itajaí

13083-970

Universidade Estadual de Campi, Campinas

03102-002

Instituto Brasileiro de Controle do Cancer - ibcc, São Paulo

90610-000

Hospital Nossa Senhora da Conc, Porto Alegre

Pontificia Universidade, Porto Alegre

T2N 4N2

Tom Baker Cancer Centre, Calgary

V5Z 4E6

BC Cancer - Vancouver Centre, Vancouver

M4N 3M5

Sunnybrook Research Institute, sunnybrook Health Sciences Ct, Toronto

M5G 2M9

University Health Network - Princess Margaret Cancer Centre, Toronto

Unknown

Centro de Estudios Clínicos SAGA SpA, Santiago

PO di Cremona, ASST di Cremona - Oncologia medica, Cremona

625 00

University Hospital Brno, Brno

140 59

Fakultni Thomayerova nemocnice, Prague

500 05

FN Hradec Kralove, Hradec Králové

100 34

FN Kralovske Vinohrady, Prague

06189

Centre de Lutte Contre le Cancer (CLCC), Nice

'00168

Fondazione Policlinico Universitario Agostino Gemelli, Roma

00152

AO S.Camillo-Forlanini, Roma

05100

Azienda Ospedaliera Santa Maria di Terni, Terni

60-569

Szpital Kliniczny Przemienienia Panskiego UM w Poznaniu, Poznan

31-826

Szpital Specjalistyczny im. L. Rydygiera w Krakowie, Krakow

05-400

Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina, Otwock

36-200

Szpital Specjalist. w Brzozowie,Podkarpacki Ośrodek Onkologi, Brzozów

35-021

Nzoz Mrukmed Lekarz Beata Madej-Mruk I Partner Sp. P., Rzeszów

80-219

COPERNICUS Podmiot Leczn. Sp z o.o.,Wojew. Centrum Onkologii, Gdansk

21-500

Wojewodzki Szpital Specjalistyczny, Biała Podlaska

02-507

Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych, Warsaw

02-781

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw

8005-226

Hospital Particular do Algarve - Gambelas-Faro, Faro

2720-276

H. Prof. Doutor Fernando Fonseca, Amadora

1649-035

H. de Santa Maria. Centro Hospitalar Lisboa Norte - Oncologia, Lisbon

4099-001

H. Santo Antonio. Centro Hospitalar do Porto, Porto

4200-072

Instituto Português Oncologia Francisco Gentil do Porto, Porto

03203

H.G.U. de Elche, Elche

07010

Hospital Universitario Son Espases, Palma de Mallorca

08025

Hospital de La Santa Creu i Sant Pau, Barcelona

08035

Hospital Universitario Vall d', Barcelona

08908

Institut Catalá d´Oncología (I.C.O.), Barcelona

CB2 0QQ

Addenbrooke's Hospital - Oncology, Cambridge

HA6 2JW

Mount Vernon Cancer Centre, Northwood

PR2 9HT

Royal Blackburn Hospital - Oncology, Preston

W6 8RF

Imperial College Healthcare NHS Trust - Hammersmith Hospital, London

M20 4BX

The Christie NHS Foundation Trust - Medical Oncology, Manchester

SM2 5PT

Royal Marsden - Sutton, Sutton

Royal Marsden Hospital, Sutton

WV10 0QP

New Cross Hospital, Wolverhampton

DE22 3NE

Royal Derby Hospital, Derby

LS9 7TF

Leeds Teaching Hospitals NHS Trust, Leeds

Sponsors
All Listed Sponsors
collaborator

Parexel

INDUSTRY

collaborator

Bristol-Myers Squibb

INDUSTRY

lead

AVEO Pharmaceuticals, Inc.

INDUSTRY